Q0IIL1

PR
Gene name
MICU1 (CBARA1)
Protein name
Calcium uptake protein 1, mitochondrial
Names
Calcium-binding atopy-related autoantigen 1 homolog
Species
Bos taurus (Bovine)
KEGG Pathway
bta:507899
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-125 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0IIL1

Entry ID Method Resolution Chain Position Source
AF-Q0IIL1-F1 Predicted AlphaFoldDB

87 variants for Q0IIL1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs432236757 15 V>G No EVA
rs469952209 16 G>R No EVA
rs449790054 20 Y>C No EVA
rs378250885 31 R>Q No EVA
rs436155732 45 T>P No EVA
rs468948572 55 A>D No EVA
rs467289266 57 A>V No EVA
rs446995406 59 S>A No EVA
rs478458517 61 P>T No EVA
rs444524273 64 N>I No EVA
rs482155615 65 N>Y No EVA
rs210935460 66 I>M No EVA
rs474077167 68 S>N No EVA
rs474785587 69 E>D No EVA
rs440150955 70 L>P No EVA
rs451545788 74 G>W No EVA
rs437681549 80 G>W No EVA
rs454685111 83 C>R No EVA
rs435182260 93 C>F No EVA
rs467250281 93 C>W No EVA
rs447115668 98 P>L No EVA
rs464573511 99 E>D No EVA
rs451035719 102 K>N No EVA
rs482118499 104 K>N No EVA
rs717423074 105 R>H No EVA
rs437329359 155 V>E No EVA
rs448698991 156 R>L No EVA
rs466332104 165 P>R No EVA
rs434867753 165 P>T No EVA
rs477160956 194 G>V No EVA
rs469725065 290 K>T No EVA
rs476012352 301 F>Y No EVA
rs449705903 311 K>N No EVA
rs472255969 328 Q>R No EVA
rs452152282 329 F>C No EVA
rs438536329 333 L>M No EVA
rs476161876 345 T>A No EVA
rs456130956 347 M>I No EVA
rs436682545 351 L>R No EVA
rs468131281 354 H>R No EVA
rs454230291 358 G>R No EVA
rs471134936 391 A>G No EVA
rs457313054 394 D>G No EVA
rs457313054 394 D>V No EVA
rs443673393 395 K>Q No EVA
rs475735075 401 V>A No EVA
rs456714900 430 L>M No EVA
rs436479229 430 L>R No EVA
rs467736223 431 S>I No EVA
rs447721010 431 S>R No EVA
rs465209021 436 V>D No EVA
rs433920717 436 V>L No EVA
rs445877476 437 S>P No EVA
rs477393891 439 M>I No EVA
rs463557431 440 K>T No EVA
rs449830081 441 Q>H No EVA
rs440949680 443 L>Q No EVA
rs461007965 443 L>V No EVA
rs472138008 445 R>I No EVA
rs458521225 445 R>S No EVA
rs476979183 446 G>A No EVA
rs439075972 446 G>C No EVA
rs476979183 446 G>D No EVA
rs476979183 446 G>V No EVA
rs454037854 447 L>F No EVA
rs442971340 447 L>V No EVA
rs474224901 447 L>W No EVA
rs465194986 449 K>N No EVA
rs451642721 450 P>A No EVA
rs449982729 451 K>N No EVA
rs470039899 451 K>Q No EVA
rs447379540 452 D>E No EVA
rs481171879 452 D>H No EVA
rs481171879 452 D>N No EVA
rs467569987 452 D>V No EVA
rs478743455 453 M>K No EVA
rs478743455 453 M>R No EVA
rs478743455 453 M>T No EVA
rs482696434 455 F>S No EVA
rs438414825 455 F>V No EVA
rs451666135 456 T>P No EVA
rs1116229390 457 R>C No EVA
rs454223871 457 R>L No EVA
rs454223871 457 R>P No EVA
rs471911932 458 L>P No EVA
rs437952637 463 W>G No EVA
rs456320165 477 K>R No EVA

No associated diseases with Q0IIL1

4 regional properties for Q0IIL1

Type Name Position InterPro Accession
domain EF-hand domain 220 - 255 IPR002048-1
domain EF-hand domain 397 - 445 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 233 - 245 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 423 - 435 IPR018247-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
  • Mitochondrion intermembrane space
  • The topology is subject to debate
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
calcium channel complex An ion channel complex through which calcium ions pass.
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
identical protein binding Binding to an identical protein or proteins.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

7 GO annotations of biological process

Name Definition
calcium import into the mitochondrion A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium ion import The directed movement of calcium ions into a cell or organelle.
mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cellular hyperosmotic salinity response Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86XE3 MICU3 Calcium uptake protein 3, mitochondrial Homo sapiens (Human) PR
Q8VCX5 Micu1 Calcium uptake protein 1, mitochondrial Mus musculus (Mouse) PR
Q6P6Q9 Micu1 Calcium uptake protein 1, mitochondrial Rattus norvegicus (Rat) PR
B1H2N3 micu1 Calcium uptake protein 1, mitochondrial Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MFRLNSLSAL AELAVGSRWY HGGSQPTQIR RRLMMVAFLG ASAVTASTGL LWKRALAESP
70 80 90 100 110 120
PSANNIKSEL GDKGKSKEEG EDCNAEKKAA GVCLEPYPEE KKKKRSGFRD RKVMEYENRI
130 140 150 160 170 180
RAYSTPDKIF RYFATLKVIS EHGESEVFMT PQDFVRSITP NEKQPEHLGL DQYTIKRFDG
190 200 210 220 230 240
KKIAQEREKF ADEGSIFYTL GECGLISFSD YIFLTTVLST PQRNFEIAFK MFDLNGDGEV
250 260 270 280 290 300
DMEEFEQVQS IIRSQTSMGM RHRDRSTTGN TLKSGLCSAL TTYFFGADLK GKLTIKNFLE
310 320 330 340 350 360
FQRKLQHDVL KLEFERHDPV DGRITERQFG GMLLAYSGVQ SKKLTAMQKQ LKKHFKEGKG
370 380 390 400 410 420
LTFQEVENFF TFLKNINDVD TALSFYHMAG ASLDKVTMQQ VARTVAKVEL SDHVCDVVFA
430 440 450 460 470
LFDCDGNGEL SNKEFVSIMK QRLMRGLEKP KDMGFTRLMQ AMWKCAQETA WDFALPKQ