AiPD: Autoinhibited Protein Database

Gene name	Acaa1b
Protein name	3-ketoacyl-CoA thiolase B, peroxisomal
Names	Acetyl-CoA acyltransferase B, Beta-ketothiolase B, Peroxisomal 3-oxoacyl-CoA thiolase B
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:235674
EC number	2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-62 (Predicted disordered autoinhibitory region) PR

1-62 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VCH0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389049570	16	E>D	No	EVA
rs3389081185	22	Q>K	No	EVA
rs222635150	29	G>S	No	EVA
rs239541379	31	L>P	No	EVA
rs3389068810	44	R>L	No	EVA
rs252770074	55	C>G	No	EVA
rs217187829	58	D>N	No	EVA
rs3389080935	68	V>A	No	EVA
rs3389026781	119	V>I	No	EVA
rs3389090868	128	Q>H	No	EVA
rs240753454	169	L>Q	No	EVA
rs224182109	179	I>T	No	EVA
rs3389074725	217	G>R	No	EVA
rs239000945	220	H>R	No	EVA
rs260444212	220	H>Y	No	EVA
rs227253067	232	N>D	No	EVA
rs3389091671	237	K>R	No	EVA
rs3389074732	246	E>D	No	EVA
rs586982565	388	V>I	No	EVA
rs3389082616	418	V>I	No	EVA

Type	Name	Position	InterPro Accession
active_site	Thiolase, active site	403 - 416	IPR020610
conserved_site	Thiolase, conserved site	367 - 383	IPR020613
active_site	Thiolase, acyl-enzyme intermediate active site	119 - 137	IPR020615
domain	Thiolase, N-terminal	38 - 291	IPR020616
domain	Thiolase, C-terminal	300 - 420	IPR020617

		Description
EC Number	2.3.1.9	Transferring groups other than amino-acyl groups
Subcellular Localization	Peroxisome	Transported into peroxisomes following association with PEX7
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

Name	Definition
acetate CoA-transferase activity	Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
acetyl-CoA C-acetyltransferase activity	Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
acetyl-CoA C-acyltransferase activity	Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
acetyl-CoA C-myristoyltransferase activity	Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.
palmitoyl-CoA oxidase activity	Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide.

Name	Definition
bile acid metabolic process	The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
fatty acid beta-oxidation	A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation using acyl-CoA oxidase	A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
phenylacetate catabolic process	The chemical reactions and pathways resulting in the breakdown of phenylacetate.
very long-chain fatty acid metabolic process	The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P27796	POT1	3-ketoacyl-CoA thiolase, peroxisomal	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P09110	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal	Homo sapiens (Human)	PR
Q921H8	Acaa1a	3-ketoacyl-CoA thiolase A, peroxisomal	Mus musculus (Mouse)	PR
P21775	Acaa1a	3-ketoacyl-CoA thiolase A, peroxisomal	Rattus norvegicus (Rat)	PR
P07871	Acaa1b	3-ketoacyl-CoA thiolase B, peroxisomal	Rattus norvegicus (Rat)	PR