P27796
Gene name |
POT1 (FOX3, POX3, YIL160C) |
Protein name |
3-ketoacyl-CoA thiolase, peroxisomal |
Names |
Acetyl-CoA acyltransferase, Beta-ketothiolase, Peroxisomal 3-oxoacyl-CoA thiolase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YIL160C |
EC number |
2.3.1.16: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P27796
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AFW | X-ray | 180 A | A/B | 25-417 | PDB |
| 1PXT | X-ray | 280 A | A/B | 28-417 | PDB |
| 3W15 | X-ray | 180 A | C | 1-15 | PDB |
| AF-P27796-F1 | Predicted | AlphaFoldDB |
4 variants for P27796
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s09-41386 | 20 | G>D | No | SGRP | |
| s09-41276 | 57 | V>I | No | SGRP | |
| s09-41108 | 113 | P>S | No | SGRP | |
| s09-40824 | 207 | F>L | No | SGRP |
No associated diseases with P27796
5 regional properties for P27796
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Thiolase, active site | 398 - 411 | IPR020610 |
| conserved_site | Thiolase, conserved site | 365 - 381 | IPR020613 |
| active_site | Thiolase, acyl-enzyme intermediate active site | 121 - 139 | IPR020615 |
| domain | Thiolase, N-terminal | 36 - 289 | IPR020616 |
| domain | Thiolase, C-terminal | 298 - 414 | IPR020617 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.16 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| peroxisomal matrix | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyl-CoA C-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| phenylacetate catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylacetate. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P09110 | ACAA1 | 3-ketoacyl-CoA thiolase, peroxisomal | Homo sapiens (Human) | PR |
| Q921H8 | Acaa1a | 3-ketoacyl-CoA thiolase A, peroxisomal | Mus musculus (Mouse) | PR |
| Q8VCH0 | Acaa1b | 3-ketoacyl-CoA thiolase B, peroxisomal | Mus musculus (Mouse) | PR |
| P21775 | Acaa1a | 3-ketoacyl-CoA thiolase A, peroxisomal | Rattus norvegicus (Rat) | PR |
| P07871 | Acaa1b | 3-ketoacyl-CoA thiolase B, peroxisomal | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQRLQSIKD | HLVESAMGKG | ESKRKNSLLE | KRPEDVVIVA | ANRSAIGKGF | KGAFKDVNTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLLYNFLNEF | IGRFPEPLRA | DLNLIEEVAC | GNVLNVGAGA | TEHRAACLAS | GIPYSTPFVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNRQCSSGLT | AVNDIANKIK | VGQIDIGLAL | GVESMTNNYK | NVNPLGMISS | EELQKNREAK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KCLIPMGITN | ENVAANFKIS | RKDQDEFAAN | SYQKAYKAKN | EGLFEDEILP | IKLPDGSICQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDEGPRPNVT | AESLSSIRPA | FIKDRGTTTA | GNASQVSDGV | AGVLLARRSV | ANQLNLPVLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYIDFQTVGV | PPEIMGVGPA | YAIPKVLEAT | GLQVQDIDIF | EINEAFAAQA | LYCIHKLGID |
| 370 | 380 | 390 | 400 | 410 | |
| LNKVNPRGGA | IALGHPLGCT | GARQVATILR | ELKKDQIGVV | SMCIGTGMGA | AAIFIKE |