P09110
PR
Gene name |
ACAA1 |
Protein name |
3-ketoacyl-CoA thiolase, peroxisomal |
Names |
Acetyl-CoA C-myristoyltransferase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Peroxisomal 3-oxoacyl-CoA thiolase |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:30 |
EC number |
2.3.1.9: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P09110
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2IIK | X-ray | 255 A | A/B | 30-423 | PDB |
| AF-P09110-F1 | Predicted | AlphaFoldDB |
367 variants for P09110
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1575270316 CA352125786 |
4 | L>V | No |
ClinGen Ensembl |
|
|
CA2315974 rs773965743 |
5 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs548723241 CA2315973 |
6 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1287612267 CA352125736 |
7 | V>L | No |
ClinGen TOPMed |
|
|
CA2315972 rs748918868 |
9 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA72881649 rs748918868 |
9 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769540697 CA2315970 |
10 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315967 rs368350978 |
12 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315968 rs781323776 |
12 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs895723344 CA72881633 |
13 | G>C | No |
ClinGen TOPMed |
|
|
CA352125599 rs1182844677 |
14 | P>Q | No |
ClinGen gnomAD |
|
|
CA2315964 rs779156817 |
16 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA2315963 rs757441807 |
17 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754009365 CA2315962 |
17 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA352125453 rs1290399594 |
19 | W>C | No |
ClinGen gnomAD |
|
|
rs1356637464 CA352125473 |
19 | W>R | No |
ClinGen gnomAD |
|
|
rs1245806392 CA352125422 |
20 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA2315961 rs764516404 |
21 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs866279413 CA72881615 |
22 | Q>K | No |
ClinGen gnomAD |
|
|
CA2315960 rs761001248 |
24 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs941466063 CA72881607 |
25 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA2315959 rs773603850 |
26 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1363730286 CA352125292 |
27 | L>M | No |
ClinGen gnomAD |
|
|
rs1308009787 CA352125286 |
27 | L>P | No |
ClinGen gnomAD |
|
|
CA72881594 rs184980517 |
28 | S>N | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA2315958 rs768053072 |
28 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1156894595 CA352125226 |
30 | A>D | No |
ClinGen gnomAD |
|
|
rs1288957907 CA352125235 |
30 | A>T | No |
ClinGen TOPMed |
|
|
CA352125220 rs1156894595 |
30 | A>V | No |
ClinGen gnomAD |
|
|
rs1251055653 CA352125202 |
31 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1449637156 CA352125208 |
31 | P>S | No |
ClinGen TOPMed |
|
|
rs1238674910 CA352125185 |
32 | Q>R | No |
ClinGen TOPMed |
|
|
CA352125170 rs1049869731 |
33 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1440409266 CA352125174 |
33 | A>P | No |
ClinGen TOPMed |
|
|
rs1049869731 CA72881589 |
33 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA352125159 rs1372716599 |
35 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1222621643 CA352125154 |
35 | A>V | No |
ClinGen gnomAD |
|
|
CA352125142 rs1357893352 |
36 | A>V | No |
ClinGen gnomAD |
|
|
rs773806251 CA2315956 |
37 | D>N | No |
ClinGen ExAC |
|
|
rs1267745399 CA352125125 |
38 | V>M | No |
ClinGen gnomAD |
|
|
CA352125096 rs1316635451 |
40 | V>L | No |
ClinGen gnomAD |
|
|
CA352125088 rs1230412673 |
41 | V>M | No |
ClinGen gnomAD |
|
|
rs1302822146 CA352125059 |
43 | G>V | No |
ClinGen gnomAD |
|
|
CA352125051 rs1333977756 |
44 | R>Q | No |
ClinGen TOPMed |
|
|
rs1449599856 CA352125055 |
44 | R>W | No |
ClinGen Ensembl |
|
|
CA72881557 rs1004255722 |
45 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA352125038 rs1004255722 |
45 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1004255722 CA352125039 |
45 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
CA72881544 rs922876523 |
46 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs772795388 CA72881535 |
46 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315953 rs772795388 |
46 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352125001 rs1161126367 |
48 | I>M | No |
ClinGen gnomAD |
|
|
rs1575269834 CA352125009 |
48 | I>V | No |
ClinGen Ensembl |
|
|
rs1479227568 CA352124995 |
49 | C>Y | No |
ClinGen gnomAD |
|
|
CA72881518 rs1048707074 |
50 | R>L | No |
ClinGen TOPMed |
|
|
rs1048707074 CA352124985 |
50 | R>P | No |
ClinGen TOPMed |
|
|
CA72881523 rs888688864 |
50 | R>W | No |
ClinGen Ensembl |
|
|
rs1220174822 CA352124964 |
52 | G>A | No |
ClinGen TOPMed |
|
|
rs1428123307 CA352124968 |
52 | G>C | No |
ClinGen gnomAD |
|
|
CA352124944 rs1463932472 |
54 | G>V | No |
ClinGen gnomAD |
|
|
rs934311705 CA72881498 |
55 | G>S | No |
ClinGen TOPMed |
|
|
CA352124930 rs1168034478 |
56 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs978483635 CA72881489 |
57 | K>M | No |
ClinGen TOPMed gnomAD |
|
|
CA352124919 rs978483635 |
57 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs978483635 CA352124920 |
57 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1198746850 CA352124833 |
58 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs776765709 CA72881313 |
59 | T>A | No |
ClinGen Ensembl |
|
|
rs772886344 CA2315931 |
60 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352124809 rs1415782334 |
60 | T>P | No |
ClinGen gnomAD |
|
|
CA352124801 rs772886344 |
60 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352124804 rs1415782334 |
60 | T>S | No |
ClinGen gnomAD |
|
|
rs1391550523 CA352124755 |
62 | D>H | No |
ClinGen gnomAD |
|
|
rs867629907 CA72881287 |
63 | E>* | No |
ClinGen Ensembl |
|
|
rs566439081 CA352124687 |
63 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1242862105 CA352124676 |
64 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2315927 rs746937159 |
66 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746937159 CA2315926 |
66 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352124627 rs746937159 |
66 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1249375831 CA352124617 |
67 | A>V | No |
ClinGen Ensembl |
|
|
CA352124594 rs1575268978 |
68 | V>G | No |
ClinGen Ensembl |
|
|
CA2315923 rs771023034 |
68 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs971976307 CA72881249 |
69 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA2315921 rs777940485 |
69 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777940485 CA352124587 |
69 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315922 rs749367861 |
69 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1042161119 CA72881248 |
70 | T>I | No |
ClinGen gnomAD |
|
|
CA352124471 rs1575268941 |
72 | V>G | No |
ClinGen Ensembl |
|
|
rs756284410 CA2315920 |
72 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1284754116 CA352124470 |
73 | L>F | No |
ClinGen gnomAD |
|
|
CA352124463 rs1575268919 |
73 | L>P | No |
ClinGen Ensembl |
|
|
rs147670996 CA2315919 |
75 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1267653225 CA352124419 |
75 | D>H | No |
ClinGen TOPMed |
|
|
rs893442512 CA72881244 |
76 | V>L | No |
ClinGen gnomAD |
|
|
CA2315916 rs755405630 |
85 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352124118 rs758971878 |
86 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1166445919 CA352124121 |
86 | I>T | No |
ClinGen TOPMed |
|
|
CA2315914 rs766833478 |
86 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749850931 CA352124047 |
89 | G>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315912 rs749850931 |
89 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 93 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1281120608 CA352122479 |
93 | Q>R | No |
ClinGen TOPMed |
|
|
CA2315887 rs759328834 |
97 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 98 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA352122430 rs1575266234 |
99 | I>V | No |
ClinGen Ensembl |
|
|
CA2315886 rs774415659 |
101 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1262166587 CA352122405 |
102 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA72879771 rs934594058 COSM1044149 |
102 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs769854681 CA2315885 |
103 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs776720228 CA2315883 |
104 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA352122387 rs1288150108 |
104 | A>V | No |
ClinGen gnomAD |
|
|
COSM446435 rs1340762162 CA352122381 |
105 | Q>* | Variant assessed as Somatic; 4.62e-05 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA2315882 rs768813709 |
105 | Q>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 107 | L>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA352122339 rs1264185121 |
109 | D>N | No |
ClinGen gnomAD |
|
|
CA2315864 rs776632031 |
111 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA72878786 rs924079349 |
112 | E>A | No |
ClinGen Ensembl |
|
|
rs1296554572 CA352122170 |
115 | P>L | No |
ClinGen TOPMed |
|
|
rs1308918469 CA352122144 |
116 | L>S | No |
ClinGen gnomAD |
|
|
rs772301831 CA2315859 |
117 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs898298981 CA72878778 |
120 | N>S | No |
ClinGen TOPMed |
|
|
CA2315857 rs145935424 |
122 | Q>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1181476 CA2315856 rs369897061 |
124 | S>L | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA352121901 COSM1422703 rs1156702815 |
125 | S>L | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs752282975 CA2315852 |
126 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA2315850 rs754614303 |
128 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA2315849 rs751301935 |
128 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1489105282 CA352121736 |
130 | V>A | No |
ClinGen gnomAD |
|
|
CA352121703 rs1267798236 |
131 | A>G | No |
ClinGen gnomAD |
|
|
CA72878707 rs953132629 |
131 | A>S | No |
ClinGen TOPMed |
|
|
CA2315848 rs766171603 |
132 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs758262605 CA2315847 |
133 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2315846 rs375526157 |
134 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs891743788 CA72878420 |
136 | G>S | No |
ClinGen TOPMed |
|
|
rs759767903 CA2315820 |
137 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA2315821 rs139247862 |
137 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA352121230 rs1422676456 |
140 | G>E | No |
ClinGen TOPMed |
|
|
CA2315819 rs774784062 |
141 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs770283001 CA72878371 |
142 | Y>* | No |
ClinGen ExAC TOPMed |
|
|
CA2315816 rs773827377 |
142 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
rs1391336596 CA352121107 |
144 | I>T | No |
ClinGen gnomAD |
|
| TCGA novel | 148 | C>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2315814 rs748612350 |
148 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs1190876306 CA352121022 |
148 | C>S | No |
ClinGen gnomAD |
|
|
CA72876467 rs997134518 |
151 | E>D | No |
ClinGen Ensembl |
|
|
CA2315795 rs765521572 |
151 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1444364912 CA352119879 |
152 | S>P | No |
ClinGen gnomAD |
|
|
CA2315794 rs762374628 |
153 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA72876440 rs1011685684 |
154 | S>Y | No |
ClinGen TOPMed |
|
|
rs768130587 CA2315792 |
157 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs768130587 CA352119787 |
157 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA352119658 rs775011311 |
160 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745534014 CA2315788 |
161 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs371675293 CA2315789 |
161 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA352119647 rs371675293 |
161 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2315786 rs145740203 |
163 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2315787 rs145740203 |
163 | N>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs754795142 CA352119604 |
164 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA2315785 rs754795142 |
164 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2315784 rs146730813 |
166 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs751653410 CA2315782 |
167 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2315781 rs780291309 |
167 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA72876383 rs1036666382 |
168 | L>F | No |
ClinGen TOPMed |
|
|
CA352119529 rs1164228515 |
169 | M>T | No |
ClinGen gnomAD |
|
|
CA72876382 rs759800711 |
169 | M>V | No |
ClinGen gnomAD |
|
| TCGA novel | 170 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs156265 CA2315779 VAR_011904 |
172 | E>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA352119374 rs1218742466 |
174 | A>V | No |
ClinGen TOPMed |
|
|
CA2315778 rs765619359 |
175 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1234298226 CA352119356 |
175 | R>K | No |
ClinGen TOPMed |
|
|
rs762132492 CA2315777 |
180 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs754337644 CA2315776 |
180 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA72876361 rs898449554 |
181 | M>I | No |
ClinGen gnomAD |
|
|
rs761191465 CA2315774 |
182 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA2315775 rs764544151 |
182 | G>W | No |
ClinGen ExAC |
|
|
CA72875301 rs767348020 |
183 | I>V | No |
ClinGen Ensembl |
|
|
CA72875299 rs917359852 |
186 | E>K | No |
ClinGen Ensembl |
|
|
rs368523915 CA2315756 |
189 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 190 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1330810879 CA352117823 |
190 | E>K | No |
ClinGen gnomAD |
|
|
rs373786619 CA2315755 |
191 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1345183235 CA352117771 |
193 | G>A | No |
ClinGen gnomAD |
|
|
rs558208794 CA2315754 |
193 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315753 rs767003724 |
194 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 195 | S>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2315752 rs759019622 |
195 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs189286587 CA2315751 |
196 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA352117698 CA2315749 rs762693594 |
197 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA2315748 rs773070608 |
198 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA2315746 rs1273986265 COSM1283204 |
199 | Q>K | Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA2315745 rs761378746 |
199 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2315743 rs776755849 |
200 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776755849 CA352117650 |
200 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs530750505 CA2315742 |
201 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs530750505 CA352117598 |
201 | T>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2315740 rs779070885 |
204 | L>V | No |
ClinGen ExAC |
|
|
rs1453496014 CA352117516 |
205 | A>V | No |
ClinGen TOPMed |
|
|
CA352117468 rs1398619233 |
207 | Q>* | No |
ClinGen gnomAD |
|
|
rs757363780 CA2315739 |
209 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA72874527 rs970031657 |
210 | A>E | No |
ClinGen TOPMed |
|
|
rs773054135 CA2315729 |
210 | A>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 211 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2315728 rs765100298 |
214 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352117085 rs1259234880 |
215 | S>N | No |
ClinGen gnomAD |
|
|
CA72874520 rs202236274 |
216 | K>* | No |
ClinGen Ensembl |
|
|
CA352117075 rs1202384989 |
216 | K>N | No |
ClinGen gnomAD |
|
|
CA2315727 rs761738586 |
219 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA352116990 rs376130915 |
223 | I>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2315725 rs376130915 |
223 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778391520 CA72874460 |
224 | V>A | No |
ClinGen Ensembl |
|
|
rs1247586737 CA352116980 |
224 | V>M | No |
ClinGen gnomAD |
|
|
CA352116948 rs1227915482 |
227 | T>P | No |
ClinGen gnomAD |
|
|
rs1380119582 CA352116932 |
228 | T>A | No |
ClinGen gnomAD |
|
|
rs774228565 CA2315723 |
229 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA352116907 rs1370106310 |
230 | V>F | No |
ClinGen gnomAD |
|
|
CA2315721 rs61095322 |
231 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1347863569 CA352116862 |
234 | K>E | No |
ClinGen gnomAD |
|
|
rs1268161331 CA352116853 |
234 | K>N | No |
ClinGen TOPMed |
|
|
rs1205935343 CA352116857 |
234 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA352116855 rs1205935343 |
234 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
CA2315719 rs113334896 |
235 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs748475139 CA2315718 |
242 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA352116759 rs1424231627 |
242 | V>M | No |
ClinGen gnomAD |
|
|
CA352116737 rs1272613401 |
244 | Q>E | No |
ClinGen gnomAD |
|
|
rs1471942469 CA352116709 |
246 | E>K | No |
ClinGen gnomAD |
|
|
rs1302551994 CA352116690 |
247 | G>C | No |
ClinGen TOPMed |
|
|
CA2315716 rs755386041 |
247 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA2315715 rs752171275 |
248 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1236690879 CA352116680 |
248 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2315714 rs140435043 |
249 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2315713 rs115896366 COSM1044147 |
249 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1215559363 CA352116633 |
250 | P>L | No |
ClinGen TOPMed |
|
|
rs1447731450 CA352116640 |
250 | P>S | No |
ClinGen TOPMed |
|
|
rs750066523 CA2315712 |
253 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA352116553 rs1226799204 |
254 | M>V | No |
ClinGen gnomAD |
|
|
rs910547843 CA72874409 |
255 | E>Q | No |
ClinGen Ensembl |
|
|
CA352116495 rs1240672128 |
256 | G>S | No |
ClinGen TOPMed |
|
|
CA2315709 rs763955025 |
257 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1292931365 CA352116446 |
258 | A>D | No |
ClinGen gnomAD |
|
|
rs933541715 CA72874388 |
261 | K>N | No |
ClinGen Ensembl |
|
|
rs1458220790 CA352116347 |
263 | A>P | No |
ClinGen gnomAD |
|
|
CA72874372 rs919532888 |
263 | A>V | No |
ClinGen Ensembl |
|
|
rs1194846578 CA352116304 |
265 | K>T | No |
ClinGen TOPMed |
|
|
rs370502860 CA2315704 |
270 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1412006270 CA352116226 |
270 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 274 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2315678 rs772648699 |
274 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1449175737 CA352115931 |
277 | Q>* | No |
ClinGen gnomAD |
|
|
CA352115866 rs1254446625 |
278 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1374011134 CA352115899 |
278 | V>M | No |
ClinGen gnomAD |
|
|
CA352115861 rs1195539451 |
279 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA352115822 rs1559475498 |
280 | D>N | No |
ClinGen Ensembl |
|
|
CA352115793 rs1392240025 |
281 | G>E | No |
ClinGen TOPMed |
|
|
CA72874139 rs917240882 |
281 | G>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 283 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA352115713 rs1448839241 |
285 | I>V | No |
ClinGen TOPMed |
|
|
CA352115678 rs1483018642 |
287 | L>P | No |
ClinGen gnomAD |
|
|
CA2315675 COSM1753182 rs756886040 |
289 | R>Q | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs778562097 CA2315676 |
289 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1575259136 CA352115559 |
291 | S>A | No |
ClinGen Ensembl |
|
| TCGA novel | 296 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1339760479 CA352115381 |
297 | G>S | No |
ClinGen gnomAD |
|
|
rs889229280 CA72874111 |
297 | G>V | No |
ClinGen Ensembl |
|
|
CA72874084 rs557033614 |
301 | L>F | No |
ClinGen 1000Genomes |
|
|
rs777522544 CA2315673 |
301 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1278058050 CA352115237 |
302 | G>W | No |
ClinGen TOPMed |
|
|
CA352115226 rs143272357 |
303 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2315672 rs143272357 |
303 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA72874071 rs4345105 |
304 | L>M | No |
ClinGen gnomAD |
|
|
CA2315670 rs767316650 |
307 | Y>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352115045 rs1559475420 |
311 | G>R | No |
ClinGen Ensembl |
|
|
rs1397615100 CA352115029 |
312 | V>F | No |
ClinGen gnomAD |
|
|
rs377196505 CA72874051 |
313 | P>L | No |
ClinGen ESP |
|
|
CA2315666 rs765272869 |
314 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA72874050 rs973530993 |
314 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs963549652 CA72874049 |
315 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
CA72874046 rs1036981545 |
316 | I>V | No |
ClinGen gnomAD |
|
|
rs761933241 CA72874034 |
318 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs761933241 CA2315665 |
318 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs140127056 CA352114813 |
319 | I>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs140127056 CA2315664 |
319 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2315662 rs763447621 |
323 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA72874029 rs980943109 |
324 | A>G | No |
ClinGen Ensembl |
|
| TCGA novel | 324 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2315661 rs775866883 |
326 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA2315660 rs772624215 |
327 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs746372804 CA2315659 |
330 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765838107 CA352113038 |
333 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765838107 CA2315637 |
333 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs117484375 CA2315634 |
339 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs746770119 CA2315633 |
340 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1448165797 CA352112777 |
341 | I>V | No |
ClinGen gnomAD |
|
|
rs151138541 CA2315631 COSM1044146 |
343 | E>K | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs750386233 CA2315630 |
344 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2315629 rs528682842 |
345 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1236950273 CA352112442 |
347 | A>G | No |
ClinGen gnomAD |
|
|
rs752944703 CA2315627 |
349 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA352112280 rs1259784366 |
351 | Q>* | No |
ClinGen TOPMed |
|
|
rs1250084097 CA352112105 |
352 | A>G | No |
ClinGen TOPMed |
|
|
rs1259030058 CA352112129 |
352 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA352112062 rs1190534320 |
353 | A>V | No |
ClinGen TOPMed |
|
|
rs371052867 CA2315607 |
354 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs377017874 CA2315608 |
354 | Y>H | No |
ClinGen ESP ExAC TOPMed |
|
|
CA72871896 rs867839524 |
355 | C>R | No |
ClinGen TOPMed |
|
|
rs1268460899 CA352111887 |
357 | E>K | No |
ClinGen gnomAD |
|
|
COSM1044145 rs755191918 CA2315605 |
360 | R>* | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs897946138 CA352111812 |
360 | R>P | No |
ClinGen TOPMed |
|
|
rs897946138 CA72871873 |
360 | R>Q | No |
ClinGen TOPMed |
|
|
CA2315602 rs142074753 |
363 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs202069337 CA2315601 |
363 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 363 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA72871864 rs202069337 |
363 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA352111762 rs142074753 |
363 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs142074753 CA352111768 |
363 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA352111732 rs1444023073 |
364 | E>G | No |
ClinGen gnomAD |
|
|
rs1354656513 CA352111752 |
364 | E>K | No |
ClinGen TOPMed |
|
| TCGA novel | 364 | E>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1553626595 CA2315597 |
366 | V>M | No |
ClinGen Ensembl |
|
|
rs762315878 CA2315596 |
367 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1163698345 CA352111616 |
368 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA352111621 rs1163698345 |
368 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs112913428 CA72871839 |
369 | L>P | No |
ClinGen Ensembl |
|
|
rs112913428 CA72871842 |
369 | L>Q | No |
ClinGen Ensembl |
|
|
rs760316562 CA2315593 |
370 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1418058073 CA352111567 |
371 | G>S | No |
ClinGen gnomAD |
|
|
CA352111544 rs1205344619 |
371 | G>V | No |
ClinGen TOPMed |
|
| TCGA novel | 371 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201922536 CA2315591 |
372 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1481791347 CA352111392 |
377 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs771877476 CA352111272 |
381 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771877476 CA2315590 |
381 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs188647131 CA2315589 |
381 | C>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs770705389 CA2315587 |
385 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA2315586 rs749249005 |
385 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1422316204 CA352111107 |
386 | Q>* | No |
ClinGen TOPMed |
|
|
rs2229528 VAR_069148 CA2315585 |
387 | V>A | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1368210524 CA352111047 |
388 | I>T | No |
ClinGen TOPMed |
|
|
CA2315583 rs138308587 |
389 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2315584 rs138308587 |
389 | T>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA352111001 rs1441426643 |
391 | L>F | No |
ClinGen gnomAD |
|
|
rs117916664 CA352110978 COSM242763 |
392 | N>I | prostate [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs117916664 CA2315580 |
392 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 393 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA352110925 rs1271671742 |
395 | K>E | No |
ClinGen TOPMed |
|
|
rs374655368 CA2315579 |
396 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA2315578 rs377002590 |
396 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs528719459 CA2315576 |
397 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2315575 rs145705119 |
397 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2315574 rs199630611 |
398 | G>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2315548 rs143586524 |
400 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2315547 rs375002308 |
403 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA352109972 rs1195598671 |
406 | S>F | No |
ClinGen gnomAD |
|
|
CA352109962 rs1256933985 |
407 | M>T | No |
ClinGen gnomAD |
|
|
CA352109970 rs1474235864 |
407 | M>V | No |
ClinGen gnomAD |
|
|
rs769791958 CA2315545 |
409 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA2315544 COSM1044144 rs148896847 |
410 | G>R | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA2315541 rs548611153 |
412 | G>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1575254439 CA352109846 |
413 | M>R | No |
ClinGen Ensembl |
|
|
CA352109798 rs1231096158 |
415 | A>V | No |
ClinGen gnomAD |
|
|
rs771165029 CA2315539 |
416 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749612882 CA2315538 |
417 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA2315534 rs140048660 |
418 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA352109710 rs1575254373 |
419 | F>L | No |
ClinGen Ensembl |
|
|
rs751145499 CA2315532 |
421 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA352109639 rs1575254365 |
421 | Y>S | No |
ClinGen Ensembl |
|
|
rs1173037316 CA352109630 |
422 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA352109632 rs1173037316 |
422 | P>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA352109593 rs1230063442 |
423 | G>E | No |
ClinGen gnomAD |
No associated diseases with P09110
5 regional properties for P09110
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Thiolase, active site | 403 - 416 | IPR020610 |
| conserved_site | Thiolase, conserved site | 367 - 383 | IPR020613 |
| active_site | Thiolase, acyl-enzyme intermediate active site | 119 - 137 | IPR020615 |
| domain | Thiolase, N-terminal | 38 - 291 | IPR020616 |
| domain | Thiolase, C-terminal | 300 - 420 | IPR020617 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.9 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| peroxisomal matrix | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
| specific granule lumen | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetate CoA-transferase activity | Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. |
| acetyl-CoA C-acetyltransferase activity | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. |
| acetyl-CoA C-acyltransferase activity | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
| acetyl-CoA C-myristoyltransferase activity | Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. |
| palmitoyl-CoA oxidase activity | Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| alpha-linolenic acid metabolic process | The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
| bile acid metabolic process | The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| fatty acid beta-oxidation using acyl-CoA oxidase | A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| phenylacetate catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylacetate. |
| very long-chain fatty acid metabolic process | The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P27796 | POT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q921H8 | Acaa1a | 3-ketoacyl-CoA thiolase A, peroxisomal | Mus musculus (Mouse) | PR |
| Q8VCH0 | Acaa1b | 3-ketoacyl-CoA thiolase B, peroxisomal | Mus musculus (Mouse) | PR |
| P21775 | Acaa1a | 3-ketoacyl-CoA thiolase A, peroxisomal | Rattus norvegicus (Rat) | PR |
| P07871 | Acaa1b | 3-ketoacyl-CoA thiolase B, peroxisomal | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRLQVVLGH | LRGPADSGWM | PQAAPCLSGA | PQASAADVVV | VHGRRTAICR | AGRGGFKDTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDELLSAVMT | AVLKDVNLRP | EQLGDICVGN | VLQPGAGAIM | ARIAQFLSDI | PETVPLSTVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RQCSSGLQAV | ASIAGGIRNG | SYDIGMACGV | ESMSLADRGN | PGNITSRLME | KEKARDCLIP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGITSENVAE | RFGISREKQD | TFALASQQKA | ARAQSKGCFQ | AEIVPVTTTV | HDDKGTKRSI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVTQDEGIRP | STTMEGLAKL | KPAFKKDGST | TAGNSSQVSD | GAAAILLARR | SKAEELGLPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGVLRSYAVV | GVPPDIMGIG | PAYAIPVALQ | KAGLTVSDVD | IFEINEAFAS | QAAYCVEKLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPPEKVNPLG | GAVALGHPLG | CTGARQVITL | LNELKRRGKR | AYGVVSMCIG | TGMGAAAVFE |
| YPGN |