P07871

PR
Gene name
Acaa1b
Protein name
3-ketoacyl-CoA thiolase B, peroxisomal
Names
Acetyl-CoA acyltransferase B, Beta-ketothiolase B, Peroxisomal 3-oxoacyl-CoA thiolase B
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:501072
EC number
2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P07871

Entry ID Method Resolution Chain Position Source
AF-P07871-F1 Predicted AlphaFoldDB

No variants for P07871

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P07871

No associated diseases with P07871

5 regional properties for P07871

Type Name Position InterPro Accession
active_site Thiolase, active site 403 - 416 IPR020610
conserved_site Thiolase, conserved site 367 - 383 IPR020613
active_site Thiolase, acyl-enzyme intermediate active site 119 - 137 IPR020615
domain Thiolase, N-terminal 38 - 291 IPR020616
domain Thiolase, C-terminal 300 - 420 IPR020617

Functions

Description
EC Number 2.3.1.9 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Peroxisome
  • Transported into peroxisomes following association with PEX7
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

3 GO annotations of molecular function

Name Definition
acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
acetyl-CoA C-myristoyltransferase activity Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.

3 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P27796 POT1 3-ketoacyl-CoA thiolase, peroxisomal Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P09110 ACAA1 3-ketoacyl-CoA thiolase, peroxisomal Homo sapiens (Human) PR
Q921H8 Acaa1a 3-ketoacyl-CoA thiolase A, peroxisomal Mus musculus (Mouse) PR
Q8VCH0 Acaa1b 3-ketoacyl-CoA thiolase B, peroxisomal Mus musculus (Mouse) PR
P21775 Acaa1a 3-ketoacyl-CoA thiolase A, peroxisomal Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MHRLQVVLGH LAGRSESSSA LQAAPCSAGF PQASASDVVV VHGRRTPIGR AGRGGFKDTT
70 80 90 100 110 120
PDELLSAVLT AVLQDVKLKP ECLGDISVGN VLQPGAGAAM ARIAQFLSGI PETVPLSAVN
130 140 150 160 170 180
RQCSSGLQAV ANIAGGIRNG SYDIGMACGV ESMTLSERGN PGNISSRLLE NEKARDCLIP
190 200 210 220 230 240
MGITSENVAE RFGISRQKQD AFALASQQKA ASAQSKGCFR AEIVPVTTTV LDDKGDRKTI
250 260 270 280 290 300
TVSQDEGVRP STTMEGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350 360
LGVLRSYAVV GVPPDIMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS QALYCVEKLG
370 380 390 400 410 420
IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR AYGVVSMCIG TGMGAAAVFE
YPGN