Q8LAR7
Gene name |
At5g60510 (MUF9.14) |
Protein name |
Dehydrodolichyl diphosphate synthase 8 |
Names |
Dedol-PP synthase 8 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G60510 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LAR7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LAR7-F1 | Predicted | AlphaFoldDB |
21 variants for Q8LAR7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00745016 | 5 | R>G | No | 1000Genomes | |
| ENSVATH07455716 | 19 | M>R | No | 1000Genomes | |
| tmp_5_24330811_C_T | 31 | R>C | No | 1000Genomes | |
| tmp_5_24330817_G_C | 33 | G>R | No | 1000Genomes | |
| ENSVATH03458250 | 67 | I>T | No | 1000Genomes | |
| ENSVATH12876708 | 73 | L>F | No | 1000Genomes | |
| ENSVATH07455717 | 91 | M>I | No | 1000Genomes | |
| ENSVATH00745017 | 91 | M>V | No | 1000Genomes | |
| ENSVATH12876714 | 125 | N>K | No | 1000Genomes | |
| ENSVATH07455719 | 141 | R>C | No | 1000Genomes | |
| ENSVATH12876725 | 144 | A>T | No | 1000Genomes | |
| tmp_5_24331231_G_C | 171 | V>L | No | 1000Genomes | |
| tmp_5_24331280_C_A | 187 | T>N | No | 1000Genomes | |
| ENSVATH00745018 | 191 | S>F | No | 1000Genomes | |
| ENSVATH14642535 | 197 | S>N | No | 1000Genomes | |
| ENSVATH14642535 | 197 | S>T | No | 1000Genomes | |
| ENSVATH12876730 | 202 | C>S | No | 1000Genomes | |
| ENSVATH03458251 | 215 | V>I | No | 1000Genomes | |
| ENSVATH14642536 | 233 | R>K | No | 1000Genomes | |
| tmp_5_24331429_C_G | 237 | H>D | No | 1000Genomes | |
| tmp_5_24331510_T_A | 264 | Y>N | No | 1000Genomes |
No associated diseases with Q8LAR7
7 regional properties for Q8LAR7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA topoisomerase, type IA, domain 2 | 146 - 242 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 289 - 545 | IPR003602 |
| domain | TOPRIM domain | 3 - 155 | IPR006171 |
| domain | DNA topoisomerase, type IA, central | 112 - 125 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 170 - 593 | IPR013497-2 |
| active_site | DNA topoisomerase, type IA, active site | 326 - 340 | IPR023406 |
| domain | DNA topoisomerase 3-like, TOPRIM domain | 3 - 167 | IPR034144 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| polyprenyltransferase activity | Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| polyprenol biosynthetic process | The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03175 | SRT1 | Dehydrodolichyl diphosphate synthase complex subunit SRT1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35196 | RER2 | Dehydrodolichyl diphosphate synthase complex subunit RER2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q86SQ9 | DHDDS | Dehydrodolichyl diphosphate synthase complex subunit DHDDS | Homo sapiens (Human) | PR |
| Q56Y11 | At5g58770 | Dehydrodolichyl diphosphate synthase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80458 | DPS | Dehydrodolichyl diphosphate synthase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q570Q8 | At5g58784 | Dehydrodolichyl diphosphate synthase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY03 | At5g58782 | Dehydrodolichyl diphosphate synthase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RX73 | At5g58780 | Dehydrodolichyl diphosphate synthase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNNTREEVGE | FTQIFNALMS | LMRKFIFKVL | RVGPIPTNIS | FIMDGNRRFA | KKRNLEGLDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHRAGFISVK | YILQYCKEIG | VPYVTLYAFG | MDNFKRGPEE | VKCVMDLMLE | KVELTIDQAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGNMNGVRII | FAGDLNSLNE | RFRAATKKLM | ELTEENRDLI | VVVCVAYSTS | VEIVHAVRDS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVRKSKTGDG | SSALELSDIE | ECMYTSVVPV | PDLVVRTGGG | DRLSNFMTWQ | TSRALLHRTE |
| 250 | 260 | 270 | |||
| ALWPELGLWH | LVWAILKFQR | MQDYLQKKKK | LH |