Q8RX73
Gene name |
At5g58780 (MZN1.22) |
Protein name |
Dehydrodolichyl diphosphate synthase 3 |
Names |
Dedol-PP synthase 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G58780 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RX73
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RX73-F1 | Predicted | AlphaFoldDB |
22 variants for Q8RX73
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00741372 | 4 | I>V | No | 1000Genomes | |
| ENSVATH03449243 | 8 | L>P | No | 1000Genomes | |
| ENSVATH14639765 | 23 | T>I | No | 1000Genomes | |
| ENSVATH03449241 | 27 | W>C | No | 1000Genomes | |
| ENSVATH03449240 | 29 | P>T | No | 1000Genomes | |
| ENSVATH14639764 | 37 | G>E | No | 1000Genomes | |
| ENSVATH03449237 | 38 | F>L | No | 1000Genomes | |
| ENSVATH12846429 | 51 | E>V | No | 1000Genomes | |
| ENSVATH03449236 | 52 | Q>K | No | 1000Genomes | |
| ENSVATH03449212 | 59 | V>E | No | 1000Genomes | |
| ENSVATH14639761 | 75 | A>E | No | 1000Genomes | |
| ENSVATH00741364 | 109 | L>F | No | 1000Genomes | |
| ENSVATH07446510 | 118 | V>I | No | 1000Genomes | |
| tmp_5_23736422_G_C | 131 | H>Q | No | 1000Genomes | |
| tmp_5_23736138_T_G | 176 | T>P | No | 1000Genomes | |
| tmp_5_23736024_T_C | 214 | K>E | No | 1000Genomes | |
| ENSVATH03449208 | 223 | E>D | No | 1000Genomes | |
| tmp_5_23735978_A_G | 229 | L>S | No | 1000Genomes | |
| tmp_5_23735894_C_T | 257 | S>N | No | 1000Genomes | |
| tmp_5_23735847_G_A | 273 | P>S | No | 1000Genomes | |
| ENSVATH12846390 | 283 | K>N | No | 1000Genomes | |
| ENSVATH12846389 | 287 | A>T | No | 1000Genomes |
No associated diseases with Q8RX73
1 regional properties for Q8RX73
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Di-trans-poly-cis-decaprenylcistransferase-like, conserved site | 245 - 262 | IPR018520 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| dehydrodolichyl diphosphate synthase activity | Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. |
| polyprenyltransferase activity | Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). |
| rubber cis-polyprenylcistransferase activity | Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| plastid membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid. |
| polyprenol biosynthetic process | The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86SQ9 | DHDDS | Dehydrodolichyl diphosphate synthase complex subunit DHDDS | Homo sapiens (Human) | PR |
| O80458 | DPS | Dehydrodolichyl diphosphate synthase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q570Q8 | At5g58784 | Dehydrodolichyl diphosphate synthase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY03 | At5g58782 | Dehydrodolichyl diphosphate synthase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LAR7 | At5g60510 | Dehydrodolichyl diphosphate synthase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56Y11 | At5g58770 | Dehydrodolichyl diphosphate synthase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSILSSLLS | LLFLFIISCF | FITSHFWFPL | SLPKILGFIK | ITSSRDDYDN | EQRDEGTYVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVEELQRELM | PRHVAVIMDG | NRRWAKRAGL | LTSQGHEAGA | KRLIEFSELC | FKLGIHTVSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FAFSTENWGR | HKIEVKCLMS | LIQHYLKSKI | QYFQREETRV | SVIGNLTKIP | ESLLRTVQEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEATRSYKKK | HLILAIDYSG | RLDILRACKS | IVKKSEKGLI | REEDVDEALI | ERELLTNCTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FPSPDLLIRT | SGEQRISNFF | LWQLAYTELF | FSPVLWPDFD | KDKLLEALVS | YQRRERRFGC |
| RV |