O80458
PR
Gene name |
DPS (ACPT, At2g23410, F26B6.6) |
Protein name |
Dehydrodolichyl diphosphate synthase 1 |
Names |
Dedol-PP synthase 1, Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G23410 |
EC number |
2.5.1.87: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O80458
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O80458-F1 | Predicted | AlphaFoldDB |
49 variants for O80458
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_9967734_G_C | 3 | S>C | No | 1000Genomes | |
| tmp_2_9967732_G_C | 4 | L>V | No | 1000Genomes | |
| ENSVATH05566276 | 13 | S>P | No | 1000Genomes | |
| tmp_2_9967674_A_G | 23 | L>P | No | 1000Genomes | |
| ENSVATH13349160 | 24 | F>Y | No | 1000Genomes | |
| ENSVATH13349158 | 33 | V>E | No | 1000Genomes | |
| ENSVATH13349159 | 33 | V>M | No | 1000Genomes | |
| ENSVATH00243512 | 38 | L>V | No | 1000Genomes | |
| ENSVATH13349157 | 41 | L>F | No | 1000Genomes | |
| ENSVATH13349156 | 48 | R>G | No | 1000Genomes | |
| ENSVATH14537486 | 50 | N>H | No | 1000Genomes | |
| tmp_2_9967142_C_G | 59 | V>L | No | 1000Genomes | |
| ENSVATH05566269 | 63 | D>E | No | 1000Genomes | |
| ENSVATH13349129 | 70 | M>I | No | 1000Genomes | |
| tmp_2_9967099_T_G | 73 | H>P | No | 1000Genomes | |
| ENSVATH05566267 | 79 | D>Y | No | 1000Genomes | |
| ENSVATH14537482 | 84 | W>* | No | 1000Genomes | |
| ENSVATH14537481 | 89 | G>R | No | 1000Genomes | |
| tmp_2_9967043_T_C | 92 | T>A | No | 1000Genomes | |
| ENSVATH05566266 | 94 | Q>R | No | 1000Genomes | |
| ENSVATH05566265 | 108 | E>D | No | 1000Genomes | |
| tmp_2_9966944_T_A | 125 | T>S | No | 1000Genomes | |
| tmp_2_9966932_C_T | 129 | G>R | No | 1000Genomes | |
| ENSVATH01874545 | 133 | I>T | No | 1000Genomes | |
| tmp_2_9966812_G_C | 143 | Q>E | No | 1000Genomes | |
| tmp_2_9966689_G_T | 157 | S>* | No | 1000Genomes | |
| tmp_2_9966690_A_T | 157 | S>T | No | 1000Genomes | |
| tmp_2_9966684_C_A | 159 | V>F | No | 1000Genomes | |
| tmp_2_9966662_T_C | 166 | N>S | No | 1000Genomes | |
| tmp_2_9966657_T_A | 168 | T>S | No | 1000Genomes | |
| tmp_2_9966633_T_G | 176 | K>Q | No | 1000Genomes | |
| tmp_2_9966632_T_C | 176 | K>R | No | 1000Genomes | |
| tmp_2_9966628_T_A | 177 | E>D | No | 1000Genomes | |
| tmp_2_9966629_T_A | 177 | E>V | No | 1000Genomes | |
| tmp_2_9966624_G_T | 179 | H>N | No | 1000Genomes | |
| ENSVATH13349112 | 192 | H>Q | No | 1000Genomes | |
| ENSVATH05566260 | 195 | M>V | No | 1000Genomes | |
| tmp_2_9966570_C_G | 197 | V>L | No | 1000Genomes | |
| tmp_2_9966558_C_T | 201 | G>R | No | 1000Genomes | |
| tmp_2_9966554_T_C | 202 | K>R | No | 1000Genomes | |
| ENSVATH05566257 | 218 | K>N | No | 1000Genomes | |
| ENSVATH05566256 | 222 | R>Q | No | 1000Genomes | |
| ENSVATH14537476 | 229 | A>T | No | 1000Genomes | |
| ENSVATH05566254 | 268 | S>T | No | 1000Genomes | |
| tmp_2_9966344_A_T | 272 | F>Y | No | 1000Genomes | |
| ENSVATH01874536 | 274 | P>L | No | 1000Genomes | |
| ENSVATH13349108 | 276 | F>L | No | 1000Genomes | |
| ENSVATH05566253 | 287 | E>K | No | 1000Genomes | |
| ENSVATH13349105 | 294 | R>S | No | 1000Genomes |
No associated diseases with O80458
1 regional properties for O80458
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Di-trans-poly-cis-decaprenylcistransferase-like, conserved site | 246 - 263 | IPR018520 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.87 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dehydrodolichyl diphosphate synthase activity | Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. |
| polyprenyltransferase activity | Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| dolichol biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. |
| plastid membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid. |
| polyprenol biosynthetic process | The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86SQ9 | DHDDS | Dehydrodolichyl diphosphate synthase complex subunit DHDDS | Homo sapiens (Human) | PR |
| Q570Q8 | At5g58784 | Dehydrodolichyl diphosphate synthase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY03 | At5g58782 | Dehydrodolichyl diphosphate synthase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LAR7 | At5g60510 | Dehydrodolichyl diphosphate synthase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RX73 | At5g58780 | Dehydrodolichyl diphosphate synthase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56Y11 | At5g58770 | Dehydrodolichyl diphosphate synthase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSLLSSDSS | LLSLLFLFLI | PCLFITSYIG | FPVFLLKLIG | LIKIKAARDN | EKRDEGTYVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REDGLQRELM | PRHVAFILDG | NRRWAKRAGL | TTSQGHEAGA | KRLIDIAELC | FELGVHTVSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FAFSTENWGR | DKIEIDNLMS | LIQHYRNKSN | IKFFHRSEVR | VSVIGNKTKI | PESLLKEIHE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IEEATKGYKN | KHLIMAVDYS | GKFDIMHACK | SLVKKSEKGL | IREEDVDEAL | IERELLTNCS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFPSPDLMIR | TSGEQRISNF | FLWQLAYSEL | FFSPVFWPDF | DKDKLLEALA | SYQRRERRFG |
| CRV |