Q03175
Gene name |
SRT1 |
Protein name |
Dehydrodolichyl diphosphate synthase complex subunit SRT1 |
Names |
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR101C |
EC number |
2.5.1.87: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q03175
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q03175-F1 | Predicted | AlphaFoldDB |
7 variants for Q03175
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-469390 | 29 | V>A | No | SGRP | |
| s13-469363 | 38 | A>E | No | SGRP | |
| s13-469319 | 53 | L>F | No | SGRP | |
| s13-469004 | 158 | G>R | No | SGRP | |
| s13-468991 | 162 | R>T | No | SGRP | |
| s13-468764 | 238 | H>Y | No | SGRP | |
| s13-468493 | 328 | Y>C | No | SGRP |
No associated diseases with Q03175
1 regional properties for Q03175
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Di-trans-poly-cis-decaprenylcistransferase-like, conserved site | 243 - 260 | IPR018520 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.87 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| dehydrodolichyl diphosphate synthase complex | A protein complex which is capable of dehydrodolichyl diphosphate synthase activity. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| dehydrodolichyl diphosphate synthase activity | Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. |
| polyprenyltransferase activity | Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dolichol biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. |
| polyprenol biosynthetic process | The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P35196 | RER2 | Dehydrodolichyl diphosphate synthase complex subunit RER2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q86SQ9 | DHDDS | Dehydrodolichyl diphosphate synthase complex subunit DHDDS | Homo sapiens (Human) | PR |
| Q8LAR7 | At5g60510 | Dehydrodolichyl diphosphate synthase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMPSIIQIQ | FVALKRLLVE | TKEQMCFAVK | SIFQRVFAWV | MSLSLFSWFY | VNLQNILIKA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRVGPVPEHV | SFIMDGNRRY | AKSRRLPVKK | GHEAGGLTLL | TLLYICKRLG | VKCVSAYAFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IENFNRPKEE | VDTLMNLFTV | KLDEFAKRAK | DYKDPLYGSK | IRIVGDQSLL | SPEMRKKIKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEEITQDGDD | FTLFICFPYT | SRNDMLHTIR | DSVEDHLENK | SPRINIRKFT | NKMYMGFHSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KCELLIRTSG | HRRLSDYMLW | QVHENATIEF | SDTLWPNFSF | FAMYLMILKW | SFFSTIQKYN |
| 310 | 320 | 330 | 340 | ||
| EKNHSLFEKI | HESVPSIFKK | KKTAMSLYNF | PNPPISVSVT | GDE |