P35196

PR
Gene name
RER2
Protein name
Dehydrodolichyl diphosphate synthase complex subunit RER2
Names
DEDOL-PP synthase, Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR002C
EC number
2.5.1.87: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

230-286 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35196

Entry ID Method Resolution Chain Position Source
AF-P35196-F1 Predicted AlphaFoldDB

4 variants for P35196

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-242233 113 R>H No SGRP
s02-242131 147 T>I No SGRP
s02-242055 172 M>I No SGRP
s02-242014 186 D>G No SGRP

No associated diseases with P35196

1 regional properties for P35196

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 203 - 220 IPR018520

Functions

Description
EC Number 2.5.1.87 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
dehydrodolichyl diphosphate synthase complex A protein complex which is capable of dehydrodolichyl diphosphate synthase activity.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

3 GO annotations of molecular function

Name Definition
dehydrodolichyl diphosphate synthase activity Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate.
polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).
prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).

4 GO annotations of biological process

Name Definition
dolichol biosynthetic process The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
polyprenol biosynthetic process The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03175 SRT1 Dehydrodolichyl diphosphate synthase complex subunit SRT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q86SQ9 DHDDS Dehydrodolichyl diphosphate synthase complex subunit DHDDS Homo sapiens (Human) PR
Q8LAR7 At5g60510 Dehydrodolichyl diphosphate synthase 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METDSGIPGH SFVLKWTKNI FSRTLRASNC VPRHVGFIMD GNRRFARKKE MDVKEGHEAG
70 80 90 100 110 120
FVSMSRILEL CYEAGVDTAT VFAFSIENFK RSSREVESLM TLARERIRQI TERGELACKY
130 140 150 160 170 180
GVRIKIIGDL SLLDKSLLED VRVAVETTKN NKRATLNICF PYTGREEILH AMKETIVQHK
190 200 210 220 230 240
KGAAIDESTL ESHLYTAGVP PLDLLIRTSG VSRLSDFLIW QASSKGVRIE LLDCLWPEFG
250 260 270 280
PIRMAWILLK FSFHKSFLNK EYRLEEGDYD EETNGDPIDL KEKKLN