Q8CFW1
PR
Gene name |
Ano2 |
Protein name |
Anoctamin-2 |
Names |
Transmembrane protein 16B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:243634 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CFW1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CFW1-F1 | Predicted | AlphaFoldDB |
48 variants for Q8CFW1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217403429 | 22 | R>W | No | EVA | |
| rs3388847241 | 115 | G>D | No | EVA | |
| rs30655010 | 138 | G>R | No | EVA | |
| rs3388865077 | 142 | D>V | No | EVA | |
| rs3388842824 | 171 | L>V | No | EVA | |
| rs3388855817 | 195 | V>M | No | EVA | |
| rs3396531201 | 196 | L>V | No | EVA | |
| rs3397328081 | 200 | A>P | No | EVA | |
| rs3397292145 | 201 | E>D | No | EVA | |
| rs3388838685 | 221 | I>T | No | EVA | |
| rs3388864628 | 242 | E>D | No | EVA | |
| rs3388861098 | 243 | H>Y | No | EVA | |
| rs3388863317 | 244 | S>I | No | EVA | |
| rs211786258 | 269 | D>N | No | EVA | |
| rs3388861070 | 292 | R>* | No | EVA | |
| rs3388864611 | 304 | A>S | No | EVA | |
| rs3388864693 | 321 | S>N | No | EVA | |
| rs3388852031 | 363 | F>S | No | EVA | |
| rs3388838604 | 408 | T>A | No | EVA | |
| rs3388838614 | 441 | V>I | No | EVA | |
| rs3388826199 | 443 | F>L | No | EVA | |
| rs3388861056 | 500 | E>K | No | EVA | |
| rs3388858548 | 527 | K>N | No | EVA | |
| rs3388856659 | 555 | I>T | No | EVA | |
| rs3388863813 | 590 | V>I | No | EVA | |
| rs3388847293 | 593 | I>F | No | EVA | |
| rs3388838602 | 620 | R>W | No | EVA | |
| rs3388842755 | 625 | A>S | No | EVA | |
| rs3388826190 | 632 | N>K | No | EVA | |
| rs3388863790 | 645 | G>V | No | EVA | |
| rs3397179566 | 652 | G>E | No | EVA | |
| rs3397086423 | 653 | S>R | No | EVA | |
| rs50042111 | 666 | C>* | No | EVA | |
| rs3397320428 | 669 | G>E | No | EVA | |
| rs3388864667 | 683 | M>R | No | EVA | |
| rs3388851989 | 751 | F>C | No | EVA | |
| rs3388856613 | 773 | V>D | No | EVA | |
| rs3388852022 | 776 | V>M | No | EVA | |
| rs3388826186 | 782 | K>R | No | EVA | |
| rs3388861047 | 889 | N>K | No | EVA | |
| rs3388842796 | 895 | K>N | No | EVA | |
| rs3388858599 | 910 | I>V | No | EVA | |
| rs3388851988 | 919 | S>G | No | EVA | |
| rs3388864646 | 937 | I>F | No | EVA | |
| rs3388863825 | 954 | E>V | No | EVA | |
| rs257634740 | 963 | T>A | No | EVA | |
| rs3388864995 | 987 | S>N | No | EVA | |
| rs3388864623 | 996 | G>R | No | EVA |
No associated diseases with Q8CFW1
1 regional properties for Q8CFW1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 79 - 337 | IPR017452 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| non-motile cilium | A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| identical protein binding | Binding to an identical protein or proteins. |
| intracellular calcium activated chloride channel activity | Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6IWH7 | ANO7 | Anoctamin-7 | Homo sapiens (Human) | PR |
| Q75V66 | ANO5 | Anoctamin-5 | Homo sapiens (Human) | PR |
| A1A5B4 | ANO9 | Anoctamin-9 | Homo sapiens (Human) | PR |
| Q9NQ90 | ANO2 | Anoctamin-2 | Homo sapiens (Human) | PR |
| Q8BH79 | Ano10 | Anoctamin-10 | Mus musculus (Mouse) | PR |
| A2AHL1 | Ano3 | Anoctamin-3 | Mus musculus (Mouse) | PR |
| Q14AT5 | Ano7 | Anoctamin-7 | Mus musculus (Mouse) | PR |
| Q6IFT6 | Ano7 | Anoctamin-7 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPGLRDIP | LLPGSPRRLS | SRTVARGSQG | PKHGQQYLKV | PGHRAPGQRD | NSSLHPSQVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRESSRDRSV | INNYLDANEP | PSSEARLSRM | HFHDNQRKVD | YVLAYHYRKR | GAHLGHGSPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSLAVISNGE | TGKERHGGGP | GDVELGPLDA | LEEERREQRD | EFEHNLMAAG | LELEKDLESK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQGSVFVRIH | APWQVLAREA | EFLKIKVPTK | KMYEIKAGGS | IAKKFSAILQ | TLSSPLQPRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PEHSNNRMKN | LSYPFSREKM | YLYNIQEKDT | FFDNATRSRI | VHEILKRTAC | SRANNTMGIN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLIANNIYEA | AYPLHDGEYD | SPGDDMNDRK | LLYQEWARYG | VFYKFQPIDL | IRKYFGEKIG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LYFAWLGLYT | SFLIPSSVIG | VIVFLYGCAT | IEEDIPSKEM | CDHQNAFTMC | PLCDKSCDYW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLSSACGTAR | ASHLFDNPAT | VFFSIFMALW | ATMFLENWKR | LQMRLGYFWD | LTGIEEEEER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SQEHSRPEYE | TKVREKLLKE | SGKSAVQKLE | ANSPEDDEDD | EDKLTWKDRF | PGYLMNFASI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LFMIALTFSI | VFGVIVYRIT | TAAALSLNKA | TRSNVRVTVT | ATAVIINLVV | ILILDEIYGA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VAKWLTKIEV | PKTEQTFEER | LILKAFLLKF | VNAYSPIFYV | AFFKGRFVGR | PGSYVYVFDG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YRMEECAPGG | CLMELCIQLS | IIMLGKQLIQ | NNIFEIGVPK | LKKLFRKLKD | ETEPGESDPD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HSKRPEQWDL | DHSLEPYTGL | TPEYMEMIIQ | FGFVTLFVAS | FPLAPVFALL | NNVIEVRLDA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KKFVTELRRP | DAVRTKDIGI | WFDILSGIGK | FSVIINAFVI | AVTSDFIPRL | VYQYSYSHNG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TLHGFVNHTL | SFFNVSQLKE | GTQPENSQFD | QEVQFCRFKD | YREPPWAPNP | YEFSKQYWSV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LSARLAFVII | FQNLVMFLSV | LVDWMIPDIP | TDISDQIKKE | KSLLVDFFLK | EEHEKVKLAD |
| 970 | 980 | 990 | 1000 | ||
| EPTQRSQGGG | DRSRRSRAAS | SAPSGRSQPG | SIASSGSQHT | NV |