AiPD: Autoinhibited Protein Database

Gene name	Ano7 (Ngep, Tmem16g)
Protein name	Anoctamin-7
Names	New gene expressed in prostate homolog, Transmembrane protein 16G
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:404545
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-70 (Predicted disordered autoinhibitory region) PR

1-70 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q14AT5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388492897	2	L>P	No	EVA
rs227820735	80	E>K	No	EVA
rs3388489324	158	L>M	No	EVA
rs3388489290	160	E>V	No	EVA
rs3412945401	162	V>M	No	EVA
rs3388492771	169	Y>*	No	EVA
rs3388492952	176	A>T	No	EVA
rs3388490437	199	Q>L	No	EVA
rs1132030835	225	A>V	No	EVA
rs3388488651	232	A>V	No	EVA
rs30382812	253	I>T	No	EVA
rs3390333944	327	C>*	No	EVA
rs3388489606	339	C>Y	No	EVA
rs3388492032	346	L>P	No	EVA
rs3388491607	367	F>V	No	EVA
rs3388489337	369	S>N	No	EVA
rs3388489337	369	S>T	No	EVA
rs30381887	385	R>Q	No	EVA
rs3388488884	408	P>S	No	EVA
rs3388488869	418	A>P	No	EVA
rs3388489095	423	T>M	No	EVA
rs3388489052	430	F>Y	No	EVA
rs3388491224	449	M>I	No	EVA
rs3388489651	456	C>*	No	EVA
rs3388489334	482	W>*	No	EVA
rs3388489778	511	Q>*	No	EVA
rs3388492781	547	Y>C	No	EVA
rs3388492938	551	F>L	No	EVA
rs3388489469	558	Y>N	No	EVA
rs3390333919	577	G>D	No	EVA
rs3390342467	577	G>R	No	EVA
rs3388488887	593	K>M	No	EVA
rs3388489620	655	V>I	No	EVA
rs30384990	660	A>V	No	EVA
rs30384987	666	P>Q	No	EVA
rs1134857243	737	H>Q	No	EVA
rs3388489039	744	F>Y	No	EVA
rs3388489093	747	F>L	No	EVA
rs3388490364	789	A>P	No	EVA
rs257935632	814	E>*	No	EVA
rs3388489352	823	E>D	No	EVA
rs30384069	843	V>A	No	EVA
rs3388491059	850	S>N	No	EVA

Type	Name	Position	InterPro Accession
domain	Olfactomedin-like domain	226 - 478	IPR003112
domain	Noelin domain	55 - 152	IPR022082

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Endoplasmic reticulum	Concentrates at sites of cell-cell contact Shows an intracellular localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
chloride channel activity	Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
phospholipid scramblase activity	Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

Name	Definition
calcium activated galactosylceramide scrambling	The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phosphatidylcholine scrambling	The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phosphatidylserine scrambling	The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phospholipid scrambling	The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
chloride transmembrane transport	The process in which chloride is transported across a membrane.
chloride transport	The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
establishment of localization in cell	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q75V66	ANO5	Anoctamin-5	Homo sapiens (Human)	PR
A1A5B4	ANO9	Anoctamin-9	Homo sapiens (Human)	PR
Q9NQ90	ANO2	Anoctamin-2	Homo sapiens (Human)	PR
Q6IWH7	ANO7	Anoctamin-7	Homo sapiens (Human)	PR
Q8BH79	Ano10	Anoctamin-10	Mus musculus (Mouse)	PR
A2AHL1	Ano3	Anoctamin-3	Mus musculus (Mouse)	PR
Q8CFW1	Ano2	Anoctamin-2	Mus musculus (Mouse)	PR
Q6IFT6	Ano7	Anoctamin-7	Rattus norvegicus (Rat)	PR