Q8BH79

PR
Gene name
Ano10 (Tmem16k)
Protein name
Anoctamin-10
Names
Transmembrane protein 16K
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102566
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

435-507 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BH79

Entry ID Method Resolution Chain Position Source
AF-Q8BH79-F1 Predicted AlphaFoldDB

44 variants for Q8BH79

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241401536 5 L>S No EVA
rs235933250 9 D>G No EVA
rs212591013 13 S>N No EVA
rs3389051906 15 F>L No EVA
rs3389083841 18 L>Q No EVA
rs33509769 21 I>L No EVA
rs230719277 26 D>G No EVA
rs3389093655 35 L>F No EVA
rs3400226106 77 V>D No EVA
rs3400866141 80 L>F No EVA
rs3389089004 86 V>F No EVA
rs3389030873 113 D>E No EVA
rs3389051957 139 D>V No EVA
rs3389093611 144 P>L No EVA
rs3413019812 147 P>S No EVA
rs3389088957 168 T>A No EVA
rs3389030875 170 V>E No EVA
rs3389093671 195 Q>R No EVA
rs3389030884 199 S>N No EVA
rs3389072221 201 R>H No EVA
rs3389085256 217 Y>H No EVA
rs3389093646 236 V>A No EVA
rs3389051934 245 I>F No EVA
rs3389051895 253 W>* No EVA
rs864287352 272 W>R No EVA
rs3400675691 274 T>P No EVA
rs3389029486 279 R>M No EVA
rs3389029406 285 R>L No EVA
rs3389085264 328 F>V No EVA
rs3389094529 343 A>T No EVA
rs3389086363 362 P>L No EVA
rs3389063839 385 T>I No EVA
rs3400226130 424 K>Q No EVA
rs3389072193 450 L>H No EVA
rs214145397 473 E>D No EVA
rs3389051969 474 V>I No EVA
rs3389094501 476 T>I No EVA
rs3389061225 485 E>V No EVA
rs3389094479 486 K>S No EVA
rs3412941821 579 Q>K No EVA
rs3389087809 580 V>M No EVA
rs3389085286 609 L>V No EVA
rs3389063807 626 R>S No EVA
rs3389093584 643 V>M No EVA

No associated diseases with Q8BH79

No regional properties for Q8BH79

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8BH79

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Shows predominantly an intracellular localization with a weak expression in the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
calcium activated cation channel activity Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
intracellular calcium activated chloride channel activity Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.

3 GO annotations of biological process

Name Definition
cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NW15 ANO10 Anoctamin-10 Homo sapiens (Human) PR
A2AHL1 Ano3 Anoctamin-3 Mus musculus (Mouse) PR
Q8CFW1 Ano2 Anoctamin-2 Mus musculus (Mouse) PR
Q14AT5 Ano7 Anoctamin-7 Mus musculus (Mouse) PR
10 20 30 40 50 60
MRVTLSTLDT CESSFTPLVV IELAQDVKDE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE
70 80 90 100 110 120
KETLENQNLY LVGASNVRLL LGAEAVGLVK ECTDAAMRAF TYGTRHNFKG FHDNNNDFLT
130 140 150 160 170 180
MAECQFIIKH ELENLRARDE KMIPGYPQAK LYPGKSLMRR LLTSGIVTQV FPLHDTEALK
190 200 210 220 230 240
KLEDTWYTRF ALKYQPIDSI RSYFGETIAL YFGFLEYFTF ALIPMAIIGL PYYLFVWEDY
250 260 270 280 290 300
DKYVIFASFN LIWSTVILEV WKRGCANMTY RWGTLVMKRQ FEEPRPGFHG VLGINSVTGR
310 320 330 340 350 360
EEPLYSSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME DWALSLHEDS GSEWTSLLLY
370 380 390 400 410 420
VPSIVYAVVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL VLKVLVFNFL NCFASLFYIA
430 440 450 460 470 480
FVLKDMKLLR QSLATLLITS QILNQVVESL LPYWLQRKYC ARVKRKVQAL KSEVDTTLYE
490 500 510 520 530 540
QVLLEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV
550 560 570 580 590 600
FKRPFAEPSA SIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKTD LVLIVVAVEH
610 620 630 640 650
ALLALKFILA FAIPDKPRHI QQKLARLEFE SLEALKQQQM KLVAENLKEE YQEDGKEAT