A2AHL1

PR
Gene name
Ano3
Protein name
Anoctamin-3
Names
Transmembrane protein 16C
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228432
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2AHL1

Entry ID Method Resolution Chain Position Source
AF-A2AHL1-F1 Predicted AlphaFoldDB

28 variants for A2AHL1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1135397005 11 F>S No EVA
rs3388575728 13 Q>K No EVA
rs3388570704 14 Q>R No EVA
rs264380805 24 I>L No EVA
rs3388572121 42 Q>H No EVA
rs3388572478 52 Q>R No EVA
rs3388571018 68 T>I No EVA
rs254807629 84 E>G No EVA
rs242937600 105 A>P No EVA
rs3388575534 162 K>R No EVA
rs3388577130 206 M>L No EVA
rs3391984599 235 Y>* No EVA
rs108888490 237 T>S No EVA
rs3388578727 241 N>Y No EVA
rs3388575851 334 G>V No EVA
rs3388579152 372 W>* No EVA
rs3388574379 438 E>V No EVA
rs3388575668 440 F>C No EVA
rs3388579177 442 C>Y No EVA
rs3388579189 478 F>I No EVA
rs3388575876 565 V>M No EVA
rs3388572087 606 I>V No EVA
rs3388578713 708 F>L No EVA
rs3388574550 731 D>Y No EVA
rs3388575687 746 M>T No EVA
rs3388574500 759 V>I No EVA
rs33212118 769 V>D No EVA
rs3392053545 969 R>* No EVA

No associated diseases with A2AHL1

No regional properties for A2AHL1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A2AHL1

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Shows an intracellular localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

7 GO annotations of biological process

Name Definition
calcium activated galactosylceramide scrambling The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phosphatidylcholine scrambling The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
chloride transmembrane transport The process in which chloride is transported across a membrane.
detection of mechanical stimulus The series of events by which a mechanical stimulus is received and converted into a molecular signal.
detection of temperature stimulus The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal.
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6IWH7 ANO7 Anoctamin-7 Homo sapiens (Human) PR
Q75V66 ANO5 Anoctamin-5 Homo sapiens (Human) PR
A1A5B4 ANO9 Anoctamin-9 Homo sapiens (Human) PR
Q9NQ90 ANO2 Anoctamin-2 Homo sapiens (Human) PR
Q8BH79 Ano10 Anoctamin-10 Mus musculus (Mouse) PR
Q8CFW1 Ano2 Anoctamin-2 Mus musculus (Mouse) PR
Q14AT5 Ano7 Anoctamin-7 Mus musculus (Mouse) PR
Q6IFT6 Ano7 Anoctamin-7 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVHHSGSIQS FKQQKGMNIS KSEITTEASL KPSRRSLPCL AQSYAHSKSL SQSASLFQST
70 80 90 100 110 120
ESESQAPTSV TFLSADKPEH VTSEESRKDS TLKCSFADLS DFCLALGKDK DYLDESEHAN
130 140 150 160 170 180
YDRSRLLNDF VTKDKPASKT KLSKNDMSYI ASSGLLFKDG KKRIDYILVY RKTNIQYDKR
190 200 210 220 230 240
NTFEKNLRAE GLMLEKEPAI ANPDIMFIKI HIPWDTLCKY AERLNIRVPF RKKCYYTDQK
250 260 270 280 290 300
NKSKSRVQNY FKRIKKWMSQ NPMVLDKSAF PELEESDCYT GPFSRARIHH FIINNKDTFF
310 320 330 340 350 360
SNATRSRIVY HMLERTKYEN GISKVGIRKL ITNGSYIAAF PPHEGAYKSS LPIKTHGPQN
370 380 390 400 410 420
NRHLLYERWA RWGMWYKHQP LDLIRMYFGE KIGLYFAWLG WYTGMLIPAA VVGLCVFFYG
430 440 450 460 470 480
LVTMNESQVS QEICKATEVF MCPLCDKNCS LQRLNDSCIY AKVTYLFDNG GTVFFAIFMA
490 500 510 520 530 540
IWATVFLEFW KRRRSILTYT WDLIEWEEEE ETLRPQFEAK YYRMEVINPI TGKPEPHQPS
550 560 570 580 590 600
SDKVTRLLVS VSGIFFMISL VITAVFAVVV YRLVVMEQFA SFKWNFVKQH WQFATSGAAV
610 620 630 640 650 660
CINFIIIMLL NLAYEKIAYL LTNLEYPRTE SEWENSFALK MFLFQFVNLN SSIFYIAFFL
670 680 690 700 710 720
GRFVGHPGKY NKLFERWRLE ECHPSGCLID LCLQMGVIMF LKQIWNNFME LGYPLIQNWW
730 740 750 760 770 780
SRHKIKRGIQ DASIPQWEND WNLQPMNIHG LMDEYLEMVL QFGFTTIFVA AFPLAPLLAL
790 800 810 820 830 840
LNNIIEIRLD AYKFVTQWRR PLPARATDIG IWLGILEGIG ILAVITNAFV IAITSDYIPR
850 860 870 880 890 900
FVYEYKYGPC ANHVKQNENC LKGYVNNSLS FFDLSELGMG KSGYCRYRDY RGPPWSSKPY
910 920 930 940 950 960
EFTLQYWHIL AARLAFIIVF EHLVFGIKSF IAYLIPDIPK GLRERIRREK YLVQEMMYEA
970 980
ELEHLQQQRR KSGQPIHHEW P