Q8CCS6

PR
Gene name
Pabpn1 (Pab2, Pabp2)
Protein name
Polyadenylate-binding protein 2
Names
PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:54196
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CCS6

Entry ID Method Resolution Chain Position Source
AF-Q8CCS6-F1 Predicted AlphaFoldDB

6 variants for Q8CCS6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389283490 164 E>V No EVA
rs3389334487 192 G>A No EVA
rs3389324746 207 H>L No EVA
rs3389327402 220 E>V No EVA
rs3389334451 259 R>H No EVA
rs3405118371 268 N>M No EVA

No associated diseases with Q8CCS6

1 regional properties for Q8CCS6

Type Name Position InterPro Accession
domain RNA recognition motif domain 168 - 245 IPR000504

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Nucleus speckle
  • Localized in cytoplasmic mRNP granules containing untranslated mRNAs
  • Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus
  • Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism
  • It is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic
  • Nucleus; nuclear speckle (By similarity)
  • Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear inclusion body An intranuclear focus at which aggregated proteins have been sequestered.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

3 GO annotations of molecular function

Name Definition
poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
protein self-association Binding to a domain within the same polypeptide.
RNA polymerase binding Binding to an RNA polymerase molecule or complex.

5 GO annotations of biological process

Name Definition
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of polynucleotide adenylyltransferase activity Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28165 PABPN1 Polyadenylate-binding protein 2 Bos taurus (Bovine) PR
Q86U42 PABPN1 Polyadenylate-binding protein 2 Homo sapiens (Human) PR
Q5XFR0 Pabpn1l Embryonic polyadenylate-binding protein 2 Mus musculus (Mouse) PR
B0BNE4 Pabpn1l Embryonic polyadenylate-binding protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGDP GGAGDYGNGL ESEELEPGEL
70 80 90 100 110 120
LPEPEPEEEP PRPRAPPGAP GPGPGSGAPG SQEEEEEPGL VEADPGDGAI EDPELEAIKA
130 140 150 160 170 180
RVREMEEEAE KLKELQNEVE KQMNMSPPPG NAGPVIMSLE EKMEADARSI YVGNVDYGAT
190 200 210 220 230 240
AEELEAHFHG CGSVNRVTIL CDKFSGHPKG FAYIEFSDKE SVRTSLALDE SLFRGRQIKV
250 260 270 280 290 300
IPKRTNRPGI STTDRGFPRS RYRARTTNYN SSRSRFYSGF NSRPRGRIYR GRARATSWYS
PY