AiPD: Autoinhibited Protein Database

Q86U42

Gene name	PABPN1
Protein name	Polyadenylate-binding protein 2
Names	PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8106
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-192 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-192 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q86U42

Entry ID	Method	Resolution	Chain	Position	Source
3B4D	X-ray	200 A	A	167-254	PDB
3B4M	X-ray	282 A	A/B/C/D	167-254	PDB
3UCG	X-ray	195 A	A	167-254	PDB
AF-Q86U42-F1	Predicted				AlphaFoldDB

224 variants for Q86U42

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000989181 rs1594987281	8	A>missing	Oculopharyngeal muscular dystrophy [ClinVar]	Yes	ClinVar dbSNP
RCV000989180 RCV000599541 rs193922941	8	A>missing	Oculopharyngeal muscular dystrophy [ClinVar]	Yes	ClinVar dbSNP
rs193922941 RCV000851331 RCV000360117	9	A>missing	Oculopharyngeal muscular dystrophy [ClinVar]	Yes	ClinVar dbSNP
RCV001268333 RCV001780224 rs1888252890	9	A>missing	Oculopharyngeal muscular dystrophy [ClinVar]	Yes	ClinVar dbSNP
rs104894466 CA254158 RCV000007793	12	G>A	Oculopharyngeal muscular dystrophy Oculopharyngeal muscular dystrophy (opmd) [ClinVar, Ensembl]	Yes	ClinGen ClinVar Ensembl dbSNP
CA10603925 RCV003133205 rs886042198 RCV000392627	57	P>S	Oculopharyngeal muscular dystrophy [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1303888031 CA388966897	3	A>V		No	ClinGen TOPMed
CA257773647 rs925400858	4	A>V		No	ClinGen TOPMed gnomAD
CA388966921 rs1446975876	5	A>V		No	ClinGen gnomAD
VAR_018179	6	A>AAAA		No	UniProt
CA388966924 rs1471120720	6	A>T		No	ClinGen TOPMed gnomAD
CA388966934 rs1164675505	6	A>V		No	ClinGen TOPMed
rs1888253108 RCV001092188	7	A>missing		No	ClinVar dbSNP
TCGA novel	8	A>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1433496791 CA388966977	9	A>V		No	ClinGen TOPMed gnomAD
rs1888255467 RCV001092189	9	A>missing		No	ClinVar dbSNP
CA388966981 rs1220650804	10	A>S		No	ClinGen TOPMed
rs193922941 RCV000288768	10	A>missing		No	ClinVar dbSNP
CA388966987 rs1594987353	10	A>V		No	ClinGen Ensembl
rs1045060319 CA388966993	11	A>P		No	ClinGen TOPMed
CA257773659 rs1045060319	11	A>S		No	ClinGen TOPMed
rs1374271994 CA388966999	11	A>V		No	ClinGen TOPMed gnomAD
CA388967020 rs1293492884	13	A>P		No	ClinGen TOPMed
CA388967017 rs1293492884	13	A>T		No	ClinGen TOPMed
rs1457043429 CA388967051	15	G>D		No	ClinGen TOPMed
rs1157430457 CA388967041	15	G>S		No	ClinGen TOPMed
CA388967057 rs1281542001	16	G>C		No	ClinGen gnomAD
rs1481132195 CA388967073	17	R>Q		No	ClinGen TOPMed
rs1176636805 CA388967070	17	R>W		No	ClinGen TOPMed
CA10605810 rs886043674 RCV000301380	18	G>C		No	ClinGen ClinVar dbSNP gnomAD
rs886043674 CA388967079	18	G>S		No	ClinGen gnomAD
CA388967097 rs1422393088	19	S>A		No	ClinGen TOPMed
rs1272658842 CA388967114	20	G>E		No	ClinGen gnomAD
TCGA novel	21	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1199259625 CA388967127	21	P>Q		No	ClinGen gnomAD
CA388967151 rs1486180308	23	R>W		No	ClinGen TOPMed
CA388967177 rs1206658925	25	R>G		No	ClinGen TOPMed
CA257773676 rs1016310389	27	L>F		No	ClinGen TOPMed
rs897635864 CA257773679	28	V>A		No	ClinGen TOPMed gnomAD
rs1594987452 CA388967246	29	P>S		No	ClinGen Ensembl
rs1439364113 CA388967287	32	G>A		No	ClinGen gnomAD
CA388967283 rs1236561277	32	G>R		No	ClinGen gnomAD
rs1177737587 CA388967316	34	E>D		No	ClinGen TOPMed gnomAD
rs1300739575 CA388967312	34	E>G		No	ClinGen TOPMed
CA388967305 rs1310540690	34	E>K		No	ClinGen TOPMed
rs993310171 CA388967335	36	G>A		No	ClinGen TOPMed gnomAD
rs993310171 CA257773683	36	G>E		No	ClinGen TOPMed gnomAD
rs1170742693 CA388967353	37	E>D		No	ClinGen TOPMed gnomAD
CA388967339 rs1478934510	37	E>K		No	ClinGen gnomAD
rs1401488248 CA388967362	38	G>E		No	ClinGen gnomAD
CA388967367 rs1465677125	39	A>T		No	ClinGen TOPMed gnomAD
CA257773690 rs954638383	40	P>S		No	ClinGen TOPMed gnomAD
CA388967393 rs1337013160	41	G>E		No	ClinGen TOPMed
CA388967390 rs1445619553	41	G>R		No	ClinGen gnomAD
CA7112525 rs752206181	42	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1333195182 CA388967427	44	G>R		No	ClinGen gnomAD
CA388967452 rs1231617329	45	D>V		No	ClinGen gnomAD
rs535276533 CA257773694	46	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA gnomAD
CA388967480 rs1594987536	47	G>R		No	ClinGen Ensembl
CA388967512 rs1375547262	48	N>K		No	ClinGen TOPMed
CA388967517 rs1174790932	49	G>R		No	ClinGen TOPMed
rs1421635538 CA388967539	50	L>P		No	ClinGen TOPMed
CA388967542 rs1256275055	51	E>K		No	ClinGen gnomAD
rs1214566908 CA388967564	52	S>A		No	ClinGen gnomAD
CA388967643 rs1243473731	57	P>L		No	ClinGen TOPMed
rs986489999 CA257773701	59	E>K		No	ClinGen TOPMed gnomAD
CA388967707 rs1478129001	63	E>D		No	ClinGen gnomAD
rs924369291 CA257773703	64	P>T		No	ClinGen TOPMed gnomAD
rs748930859 CA7112528	65	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1420857469 CA388967723	65	E>K		No	ClinGen gnomAD
rs1394623996 CA388967748	67	E>Q		No	ClinGen TOPMed
CA388967771 rs1411649143	68	P>L		No	ClinGen gnomAD
rs1392510529 CA388967789	70	P>S		No	ClinGen TOPMed gnomAD
rs1392510529 CA388967787	70	P>T		No	ClinGen TOPMed gnomAD
CA388967797 rs1385436714	71	E>K		No	ClinGen gnomAD
rs935460519 CA257773706	72	E>G		No	ClinGen TOPMed
rs1323362259 CA388967834	73	E>K		No	ClinGen TOPMed gnomAD
rs1276316872 CA388967885	76	R>P		No	ClinGen gnomAD
CA388967883 rs1421817437	76	R>W		No	ClinGen TOPMed
CA257773714 rs988289631	77	P>A		No	ClinGen TOPMed gnomAD
CA388967909 rs746197440	77	P>H		No	ClinGen ExAC gnomAD
CA7112531 rs746197440	77	P>L		No	ClinGen ExAC gnomAD
CA388967901 rs988289631	77	P>S		No	ClinGen TOPMed gnomAD
CA388967921 rs1594987701	78	R>C		No	ClinGen Ensembl
TCGA novel	78	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	79	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388967952 rs1204501680	80	P>H		No	ClinGen TOPMed
CA388967954 rs1204501680	80	P>L		No	ClinGen TOPMed
CA388967958 rs1207809520	81	P>A		No	ClinGen TOPMed gnomAD
rs912588128 CA257773722	81	P>L		No	ClinGen TOPMed gnomAD
rs912588128 CA388967972	81	P>Q		No	ClinGen TOPMed gnomAD
rs912588128 CA388967968	81	P>R		No	ClinGen TOPMed gnomAD
CA388967960 rs1207809520	81	P>S		No	ClinGen TOPMed gnomAD
rs1351926304 CA388968018	83	A>V		No	ClinGen TOPMed
COSM3706193 CA388968031 rs1261029476	85	G>S	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA257773725 rs537399244	86	P>L		No	ClinGen 1000Genomes
CA388968050 rs1164926833	86	P>S		No	ClinGen gnomAD
rs1456099054 CA388968069	87	G>E		No	ClinGen gnomAD
rs1305681414 CA388968090	89	G>C		No	ClinGen TOPMed
rs949653857 CA257773726	90	S>L		No	ClinGen TOPMed gnomAD
CA7112533 rs772490762	91	G>E		No	ClinGen ExAC gnomAD
CA388968148 rs1045766366	92	A>D		No	ClinGen TOPMed gnomAD
rs1045766366 CA257773729	92	A>G		No	ClinGen TOPMed gnomAD
rs942675330 CA257773734	93	P>L		No	ClinGen Ensembl
CA388968169 rs1396655065	94	G>C		No	ClinGen gnomAD
CA7112536 rs768844162	95	S>G		No	ClinGen ExAC gnomAD
rs1249857209 CA388968199	96	Q>H		No	ClinGen TOPMed
CA7112537 rs777032493	96	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA388968222 rs1290678545	97	E>D		No	ClinGen gnomAD
TCGA novel	100	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762104467 CA388968316 CA7112539	101	E>D		No	ClinGen ExAC TOPMed gnomAD
CA388968309 rs1354143353	101	E>G		No	ClinGen gnomAD
CA7112540 rs765448940	102	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs751341605 CA7112541	105	V>I		No	ClinGen ExAC TOPMed gnomAD
CA7112542 rs759305760	107	G>V		No	ClinGen ExAC gnomAD
rs1208507044 CA388968448	109	P>L		No	ClinGen TOPMed
rs1356131732 CA388968501	112	G>S		No	ClinGen TOPMed
CA388968523 rs1241110428	113	A>S		No	ClinGen TOPMed gnomAD
rs1380596363 CA388968532	113	A>V		No	ClinGen gnomAD
CA388968598 rs1360412492	117	P>Q		No	ClinGen gnomAD
rs1157277111 CA388968592	117	P>T		No	ClinGen gnomAD
TCGA novel	118	E>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs570708643 CA257774006	118	E>K		No	ClinGen Ensembl
CA388968800 rs1171417432	125	R>*		No	ClinGen gnomAD
rs1464646568 CA388968889	131	E>K		No	ClinGen TOPMed
TCGA novel	138	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756722959 CA388969002	138	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	142	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	146	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278212105 CA388969142	147	M>V		No	ClinGen gnomAD
CA388969215 rs1319392954	151	P>S		No	ClinGen TOPMed gnomAD
rs780542932 CA7112570	152	P>S		No	ClinGen ExAC TOPMed gnomAD
CA388969257 rs1339852651	153	P>L		No	ClinGen TOPMed gnomAD
rs183579627 CA7112571	153	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1434815340 CA388969262	154	G>C		No	ClinGen TOPMed
rs1043282787 CA257774037 COSM75823	155	N>S	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
TCGA novel	157	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758090716 CA7112589	158	P>A		No	ClinGen ExAC gnomAD
CA7112590 rs766089676	158	P>L		No	ClinGen ExAC TOPMed gnomAD
rs201354726 CA257774344	160	I>T		No	ClinGen 1000Genomes
CA388969516 rs1159070981	161	M>V		No	ClinGen TOPMed gnomAD
rs755335276 CA7112592	163	I>T		No	ClinGen ExAC gnomAD
CA7112593 rs781778407	165	E>K		No	ClinGen ExAC gnomAD
TCGA novel	165	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7112595 rs144896214	167	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388969670 rs1359244331	167	M>V		No	ClinGen gnomAD
TCGA novel	169	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388969821 rs1019200988	171	A>G		No	ClinGen TOPMed gnomAD
rs1019200988 CA257774356	171	A>V		No	ClinGen TOPMed gnomAD
rs1182247856 CA388969845	172	R>H		No	ClinGen gnomAD
rs147957101 CA7112597	174	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA257774367 rs996174582	175	Y>C		No	ClinGen TOPMed gnomAD
CA7112600 rs201713476	178	N>S		No	ClinGen ESP ExAC gnomAD
TCGA novel	187	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7112631 rs753139856	190	A>V		No	ClinGen ExAC gnomAD
CA7112634 rs116983161	195	C>W		No	ClinGen ExAC gnomAD
CA7112635 rs757395524	200	R>H		No	ClinGen ExAC TOPMed gnomAD
CA257774584 rs981278088	209	S>N		No	ClinGen TOPMed
rs1267813667 CA388971582	211	H>N		No	ClinGen gnomAD
rs751724696 CA7112662	216	A>V		No	ClinGen ExAC gnomAD
rs1354255824 CA388971900	218	I>V		No	ClinGen gnomAD
RCV000178894 CA246085 rs794727719	221	S>P		No	ClinGen ClinVar Ensembl dbSNP
CA388972051 rs1461189820	222	D>E		No	ClinGen Ensembl
CA7112665 rs749040116	222	D>G		No	ClinGen ExAC
rs1258958708 CA388972075	223	K>R		No	ClinGen gnomAD
CA388972114 rs1337764696	225	S>T		No	ClinGen TOPMed
CA257774977 rs376401654	239	G>R		No	ClinGen ESP
TCGA novel	242	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1469414245 CA388972622	245	I>F		No	ClinGen gnomAD
CA257775047 rs1002922017	246	P>A		No	ClinGen TOPMed
CA7112690 rs768225992	247	K>E		No	ClinGen ExAC gnomAD
rs1216576502 CA388972675	248	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388972854 rs1272585147	256	T>I		No	ClinGen TOPMed
rs770139042 CA7112693	259	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7112692 rs748568880	259	R>W		No	ClinGen ExAC TOPMed gnomAD
CA388972938 rs1311819635	260	G>S		No	ClinGen gnomAD
CA7112694 rs367775939	261	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs886044639 CA388973048	263	R>*		No	ClinGen TOPMed gnomAD
CA388973045 rs886044639	263	R>G		No	ClinGen TOPMed gnomAD
rs771417165 CA7112696	263	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7112697 rs774324245	264	A>V		No	ClinGen ExAC TOPMed gnomAD
rs143507010 CA7112698	265	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs371234278 CA257775059	265	R>H		No	ClinGen ESP
rs767869416 CA7112699	266	Y>C		No	ClinGen ExAC gnomAD
CA7112700 rs368547431	267	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs761771221 CA7112701	267	R>H		No	ClinGen ExAC gnomAD
rs767498336 CA388973165	268	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1421864106 CA388973159 COSM1562691	268	A>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1421864106 CA388973153	268	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7112703 rs767498336	268	A>V		No	ClinGen ExAC TOPMed gnomAD
rs140804809 CA7112705	269	R>Q		No	ClinGen ESP ExAC TOPMed
rs758290474 CA7112704	269	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7112706 rs751037301	270	T>N		No	ClinGen ExAC gnomAD
CA257775086 rs559247359	272	N>S		No	ClinGen 1000Genomes
CA7112708 rs754497019	273	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1408639932 CA388973250	273	Y>H		No	ClinGen TOPMed
rs770189815 CA7112711	277	R>C		No	ClinGen ExAC TOPMed gnomAD
rs778129238 CA7112712	277	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1322681096 CA388973400	278	S>P		No	ClinGen gnomAD
CA7112714 rs201001377 COSM3377368	279	R>*	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1470037838 CA388973418	279	R>Q		No	ClinGen TOPMed
CA7112715 rs774866651	281	Y>C		No	ClinGen ExAC gnomAD
rs774866651 CA7112716	281	Y>S		No	ClinGen ExAC gnomAD
rs1217365026 CA388973505	282	S>R		No	ClinGen gnomAD
CA388973662 rs1474513454	288	P>L		No	ClinGen gnomAD
CA7112717 rs772278345	288	P>T		No	ClinGen ExAC gnomAD
CA388973679 rs760957465	289	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7112719 rs760957465	289	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA257775131 rs371919339	289	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA388973705 rs1165283571	291	R>C		No	ClinGen gnomAD
CA388973711 rs1363598356 COSM954674	291	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs762744505 CA7112722	292	V>A		No	ClinGen ExAC gnomAD
CA7112721 rs750353883	292	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1428112128 CA388973748	293	Y>C		No	ClinGen TOPMed gnomAD
rs1317226440 CA388974171	295	G>S		No	ClinGen TOPMed
CA388974184 rs1173802358	296	R>Q		No	ClinGen gnomAD
rs1470706211 CA388974181	296	R>W		No	ClinGen TOPMed gnomAD
CA257775722 rs200293075	297	A>T		No	ClinGen 1000Genomes
rs199716577 CA257775729	297	A>V		No	ClinGen 1000Genomes
rs1404969478 CA388974236	299	A>P		No	ClinGen gnomAD
CA7112755 rs746186777	299	A>V		No	ClinGen ExAC gnomAD
rs1376751675 CA388974335	303	Y>C		No	ClinGen TOPMed
CA388974420 rs1594991955	306	Y>*		No	ClinGen Ensembl
rs1594991957 CA388974425	307	Y>K		No	ClinGen Ensembl

1 associated diseases with Q86U42

[MIM: 164300]: Oculopharyngeal muscular dystrophy (OPMD)

A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement. {ECO:0000269|PubMed:12673802}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement. {ECO:0000269|PubMed:12673802}. Note=The disease is caused by variants affecting the gene represented in this entry.

1 regional properties for Q86U42

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	172 - 249	IPR000504

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Nucleus speckle	Localized in cytoplasmic mRNP granules containing untranslated mRNAs Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus (PubMed:10688363) Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (By similarity) Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity) Intranuclear filamentous inclusions or 'aggregates' are detected in the myocytes of patients; these inclusions contain PABPN1, ubiquitin, subunits of the proteasome and poly(A) RNA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear inclusion body	An intranuclear focus at which aggregated proteins have been sequestered.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA polymerase binding	Binding to an RNA polymerase molecule or complex.

7 GO annotations of biological process

Name	Definition
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
muscle contraction	A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
poly(A)+ mRNA export from nucleus	The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of polynucleotide adenylyltransferase activity	Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity.
RNA processing	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q28165	PABPN1	Polyadenylate-binding protein 2	Bos taurus (Bovine)	PR
Q5XFR0	Pabpn1l	Embryonic polyadenylate-binding protein 2	Mus musculus (Mouse)	PR
Q8CCS6	Pabpn1	Polyadenylate-binding protein 2	Mus musculus (Mouse)	PR
B0BNE4	Pabpn1l	Embryonic polyadenylate-binding protein 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAAAAAAAAA	AGAAGGRGSG	PGRRRHLVPG	AGGEAGEGAP	GGAGDYGNGL	ESEELEPEEL
70	80	90	100	110	120
LLEPEPEPEP	EEEPPRPRAP	PGAPGPGPGS	GAPGSQEEEE	EPGLVEGDPG	DGAIEDPELE
130	140	150	160	170	180
AIKARVREME	EEAEKLKELQ	NEVEKQMNMS	PPPGNAGPVI	MSIEEKMEAD	ARSIYVGNVD
190	200	210	220	230	240
YGATAEELEA	HFHGCGSVNR	VTILCDKFSG	HPKGFAYIEF	SDKESVRTSL	ALDESLFRGR
250	260	270	280	290	300
QIKVIPKRTN	RPGISTTDRG	FPRARYRART	TNYNSSRSRF	YSGFNSRPRG	RVYRGRARAT

SWYSPY