AiPD: Autoinhibited Protein Database

Gene name	Pabpn1l (Epabp2, Gm1108, Pabpnl1)
Protein name	Embryonic polyadenylate-binding protein 2
Names	Embryonic poly(A)-binding protein 2, ePABP-2, ePABP2, Embryonic poly(A)-binding protein type II, Poly(A)-binding protein nuclear-like 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:382035
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-164 (Predicted disordered autoinhibitory region) PR

1-164 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5XFR0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389014710	9	L>V	No	EVA
rs236908482	34	G>S	No	EVA
rs264790772	37	E>K	No	EVA
rs248907333	45	A>V	No	EVA
rs3388967158	54	E>K	No	EVA
rs259824009	79	F>Y	No	EVA
rs3399717448	83	L>F	No	EVA
rs3389014742	94	E>Q	No	EVA
rs3389022826	98	A>V	No	EVA
rs1133448735	102	P>T	No	EVA
rs3388986293	103	P>S	No	EVA
rs1134807238	105	V>I	No	EVA
rs1134224468	108	K>R	No	EVA
rs33110169	113	E>K	No	EVA
rs3413072071	119	Q>R	No	EVA
rs3389020557	177	D>G	No	EVA
rs3389010841	180	S>Y	No	EVA
rs3389022789	194	H>Q	No	EVA
rs3389016116	195	R>T	No	EVA
rs3389016687	208	F>I	No	EVA
rs3389014743	211	R>W	No	EVA
rs3388992336	213	I>F	No	EVA
rs3388992336	213	I>V	No	EVA
rs3389016110	225	I>N	No	EVA
rs3389016693	226	S>I	No	EVA
rs33250225	239	N>S	No	EVA
rs3389010859	245	H>Y	No	EVA
rs254301586	264	G>R	No	EVA
rs3388998078	266	A>S	No	EVA

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	143 - 220	IPR000504

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
maternal-to-zygotic transition of gene expression	Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome.
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
negative regulation of protein ubiquitination	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q28165	PABPN1	Polyadenylate-binding protein 2	Bos taurus (Bovine)	PR
Q86U42	PABPN1	Polyadenylate-binding protein 2	Homo sapiens (Human)	PR
Q8CCS6	Pabpn1	Polyadenylate-binding protein 2	Mus musculus (Mouse)	PR
B0BNE4	Pabpn1l	Embryonic polyadenylate-binding protein 2	Rattus norvegicus (Rat)	PR