AiPD: Autoinhibited Protein Database

Gene name	PABPN1 (PAB2, PABP2)
Protein name	Polyadenylate-binding protein 2
Names	PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1
Species	Bos taurus (Bovine)
KEGG Pathway	bta:282298
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

29-189 (Predicted disordered autoinhibitory region) PR

29-189 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q28165-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs135332733	2	A>G	No	EVA
rs136962288	4	A>G	No	EVA
rs480644452	24	R>W	No	EVA
rs470292891	72	E>K	No	EVA
rs477998442	92	A>V	No	EVA
rs798982861	111	D>N	No	EVA
rs441131702	115	E>*	No	EVA
rs478938532	152	P>L	No	EVA
rs434967747	180	D>E	No	EVA
rs435108526	188	L>I	No	EVA
rs464895450	191	H>P	No	EVA
rs446279219	191	H>Q	No	EVA
rs432762379	194	G>R	No	EVA
rs135154461	195	C>W	No	EVA
rs468932349	258	D>G	No	EVA
rs462066478	259	R>Q	No	EVA
rs448238765	279	R>*	No	EVA
rs480360789	288	P>L	No	EVA
rs461831736	292	V>L	No	EVA
rs136139693	297	A>P	No	EVA

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	172 - 249	IPR000504

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Nucleus speckle	Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity) Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (PubMed:10688363) Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic Nucleus; nuclear speckle Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear inclusion body	An intranuclear focus at which aggregated proteins have been sequestered.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

Name	Definition
protein self-association	Binding to a domain within the same polypeptide.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA polymerase binding	Binding to an RNA polymerase molecule or complex.

Name	Definition
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of polynucleotide adenylyltransferase activity	Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86U42	PABPN1	Polyadenylate-binding protein 2	Homo sapiens (Human)	PR
Q5XFR0	Pabpn1l	Embryonic polyadenylate-binding protein 2	Mus musculus (Mouse)	PR
Q8CCS6	Pabpn1	Polyadenylate-binding protein 2	Mus musculus (Mouse)	PR
B0BNE4	Pabpn1l	Embryonic polyadenylate-binding protein 2	Rattus norvegicus (Rat)	PR