Q8C7V3
Gene name |
Utp15 |
Protein name |
U3 small nucleolar RNA-associated protein 15 homolog |
Names |
Src-associated protein SAW |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:105372 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C7V3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C7V3-F1 | Predicted | AlphaFoldDB |
10 variants for Q8C7V3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389309603 | 10 | Q>L | No | EVA | |
| rs3389283063 | 39 | G>C | No | EVA | |
| rs3389299767 | 63 | H>P | No | EVA | |
| rs3389290561 | 119 | E>D | No | EVA | |
| rs252727000 | 325 | T>A | No | EVA | |
| rs242268376 | 458 | V>I | No | EVA | |
| rs3389309659 | 461 | K>* | No | EVA | |
| rs3389294981 | 462 | K>R | No | EVA | |
| rs3389265211 | 468 | E>K | No | EVA | |
| rs3389301411 | 477 | Q>* | No | EVA |
No associated diseases with Q8C7V3
10 regional properties for Q8C7V3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 31 - 66 | IPR001680-1 |
| repeat | WD40 repeat | 69 - 108 | IPR001680-2 |
| repeat | WD40 repeat | 111 - 193 | IPR001680-3 |
| repeat | WD40 repeat | 196 - 233 | IPR001680-4 |
| repeat | WD40 repeat | 237 - 317 | IPR001680-5 |
| domain | U3 small nucleolar RNA-associated protein 15, C-terminal | 343 - 490 | IPR018983 |
| conserved_site | WD40 repeat, conserved site | 137 - 151 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 95 - 109 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 137 - 151 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 180 - 194 | IPR020472-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of rRNA processing | Any process that activates or increases the frequency, rate or extent of rRNA processing. |
| positive regulation of transcription by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04305 | UTP15 | U3 small nucleolar RNA-associated protein 15 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9BVA0 | KATNB1 | Katanin p80 WD40 repeat-containing subunit B1 | Homo sapiens (Human) | PR |
| Q8BG40 | Katnb1 | Katanin p80 WD40 repeat-containing subunit B1 | Mus musculus (Mouse) | PR |
| A2RRU3 | Utp15 | U3 small nucleolar RNA-associated protein 15 homolog | Rattus norvegicus (Rat) | PR |
| O82266 | SWA1 | Protein SLOW WALKER 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGYKPVAIQ | TYPVLGEKIT | QDTLYWNNYK | TPVQIKEFGA | VSKVDFSPQL | PYNYAVTASS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIHIYGRYSQ | EPVKTFSRFK | DTAYCATFRQ | DGQLLVAGSE | DGVVQLFDIN | GRAPLRQFEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HTKAVHTVDF | TADNYHVVSG | ADDYTVKLWD | IPNSKEILTF | KEHSDYVRCG | CASKLNPDLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTGSYDHTVK | IFDARTNKNV | LCVEHGQPVE | SVLLFPSGGL | LVSAGGRYVK | VWDMLKGGQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVSLKNHHKT | VTCLCLSSSG | QRLLSGSLDR | KVKVYSTTSY | KVVHSFDYAA | SILSLALSHQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DETIVVGMTN | GILSVKHRKS | EAKKTSLPRR | RRPAYRTFIK | GKNYLKQRDD | IMVSRPAKKH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LEGYDKDLKS | FRVSQALDRV | LEPKCVIRTP | EVTVSIIKEL | TRRGVLANAL | AGRDEKEVTR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLNFLIRNLS | QPRFAPVLIN | AAEIIIDIYL | PVIGQSSVVD | KKFIVLQELV | EKEIDYQREL |
| 490 | 500 | 510 | 520 | ||
| LETLGMMDML | FATMTRNDSD | PVPEHVPAEL | PEEKTESPTQ | PSDTDKNS |