O82266

PR
Gene name
SWA1
Protein name
Protein SLOW WALKER 1
Names
Protein EMBRYO SAC DEVELOPMENT ARREST 13, Protein EMBRYO SAC DEVELOPMENT ARREST 19
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G47990
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O82266

Entry ID Method Resolution Chain Position Source
AF-O82266-F1 Predicted AlphaFoldDB

38 variants for O82266

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_19638594_T_G 3 E>D No 1000Genomes
tmp_2_19638532_G_A 24 S>L No 1000Genomes
tmp_2_19638508_G_A 32 S>L No 1000Genomes
tmp_2_19638460_G_T 48 T>K No 1000Genomes
ENSVATH13672477 58 L>S No 1000Genomes
ENSVATH05737385 59 A>S No 1000Genomes
tmp_2_19638388_T_G 72 H>P No 1000Genomes
ENSVATH02000427 83 S>L No 1000Genomes
tmp_2_19638320_C_T 95 V>I No 1000Genomes
tmp_2_19638196_G_A 136 A>V No 1000Genomes
ENSVATH05737383 149 L>V No 1000Genomes
ENSVATH05737382 161 K>N No 1000Genomes
ENSVATH14625936 192 S>L No 1000Genomes
ENSVATH13672475 210 V>G No 1000Genomes
tmp_2_19637968_G_A 212 T>M No 1000Genomes
ENSVATH02000426 214 N>K No 1000Genomes
ENSVATH02000425 235 G>A No 1000Genomes
ENSVATH02000424 236 L>M No 1000Genomes
ENSVATH02000424 236 L>V No 1000Genomes
ENSVATH05737380 247 V>L No 1000Genomes
ENSVATH05737379 254 G>E No 1000Genomes
tmp_2_19637835_C_A 256 M>I No 1000Genomes
tmp_2_19637833_A_C 257 V>G No 1000Genomes
tmp_2_19637831_A_G 258 C>R No 1000Genomes
tmp_2_19637803_A_G 267 V>A No 1000Genomes
ENSVATH00801947 271 R>H No 1000Genomes
tmp_2_19637780_T_C 275 M>V No 1000Genomes
tmp_2_19637581_T_G 341 D>A No 1000Genomes
ENSVATH02000423 349 S>N No 1000Genomes
ENSVATH14625934 350 L>S No 1000Genomes
tmp_2_19637431_T_A 391 K>M No 1000Genomes
tmp_2_19637276_C_T 443 V>M No 1000Genomes
tmp_2_19637248_C_T 452 G>E No 1000Genomes
tmp_2_19637224_C_G 460 R>T No 1000Genomes
tmp_2_19637162_T_C 481 T>A No 1000Genomes
ENSVATH02000420 499 L>F No 1000Genomes
ENSVATH13672467 521 A>T No 1000Genomes
tmp_2_19637027_T_C 526 I>V No 1000Genomes

No associated diseases with O82266

2 regional properties for O82266

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 375 - 383 IPR018039
domain Intermediate filament, rod domain 78 - 389 IPR039008

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Localized in the nucleolus in interphase cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

6 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
megagametogenesis The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04305 UTP15 U3 small nucleolar RNA-associated protein 15 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8C7V3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Mus musculus (Mouse) PR
A2RRU3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEEELRVRLN DHQVSKVFPV KPKSTAKPVS ESETPESRYW SSFKNHSTPN LVSSVAALAF
70 80 90 100 110 120
SPVHPHSLAV AHSATVSLFS SQSLSSSRRF SFRDVVSSVC FRSDGALFAA CDLSGVVQVF
130 140 150 160 170 180
DIKERMALRT LRSHSAPARF VKYPVQDKLH LVSGGDDGVV KYWDVAGATV ISDLLGHKDY
190 200 210 220 230 240
VRCGDCSPVN DSMLVTGSYD HTVKVWDARV HTSNWIAEIN HGLPVEDVVY LPSGGLIATA
250 260 270 280 290 300
GGNSVKVWDL IGGGKMVCSM ESHNKTVTSL RVARMESAES RLVSVALDGY MKVFDYGRAK
310 320 330 340 350 360
VTYSMRFPAP LMSLGLSPDG STRVIGGSNG MVFAGKKKVR DVVGGQKKSL NLWSLISDVD
370 380 390 400 410 420
ESRRRALRPT YFRYFQRGQS EKPSKDDYLV KEKKGLKLTR HDKLLKKFRH KEALVSVLEE
430 440 450 460 470 480
KKPANVVAVM EELVARRKLM KCVSNMEEGE LGMLLGFLQR YCTVQRYSGL LMGLTKKVLE
490 500 510 520
TRAEDIKGKN EFKGLLRNLK REVNQEIRIQ QSLLEIQGVI APLMRIAGRS