Q04305

PR
Gene name
UTP15 (YMR093W, YM9582.18)
Protein name
U3 small nucleolar RNA-associated protein 15
Names
U3 snoRNA-associated protein 15, U three protein 15, U3 protein 15 required for transcription, t-UTP15
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR093W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

22 structures for Q04305

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A LJ 1-513 PDB
6KE6 EM 340 A AF 1-513 PDB
6LQP EM 320 A AF 1-513 PDB
6LQQ EM 410 A AF 1-513 PDB
6LQR EM 860 A AF 1-513 PDB
6LQS EM 380 A AF 1-513 PDB
6LQT EM 490 A AF 1-513 PDB
6LQU EM 370 A AF 1-513 PDB
6LQV EM 480 A AF 1-513 PDB
6ND4 EM 430 A J 1-513 PDB
6ZQA EM 440 A UO 1-513 PDB
6ZQB EM 390 A UO 1-513 PDB
6ZQC EM 380 A UO 1-513 PDB
6ZQD EM 380 A UO 1-513 PDB
6ZQE EM 710 A UO 1-513 PDB
7AJT EM 460 A UO 1-513 PDB
7AJU EM 380 A UO 1-513 PDB
7D4I EM 400 A AF 1-513 PDB
7D5S EM 460 A AF 1-513 PDB
7D63 EM 1230 A AF 1-513 PDB
7SUK EM 399 A LJ 1-513 PDB
AF-Q04305-F1 Predicted AlphaFoldDB

4 variants for Q04305

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-454023 4 A>T No SGRP
s13-454038 9 I>V No SGRP
s13-455023 337 R>H No SGRP
s13-455311 433 G>A No SGRP

No associated diseases with Q04305

2 regional properties for Q04305

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 381 - 389 IPR018039
domain Intermediate filament, rod domain 83 - 395 IPR039008

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Associated with ribosomal chromatin, even in the absence of transcription
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
rDNA heterochromatin A region of heterochromatin located at the rDNA repeats in a chromosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
t-UTP complex A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

1 GO annotations of molecular function

Name Definition
U3 snoRNA binding Binding to a U3 small nucleolar RNA.

4 GO annotations of biological process

Name Definition
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8C7V3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Mus musculus (Mouse) PR
A2RRU3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Rattus norvegicus (Rat) PR
O82266 SWA1 Protein SLOW WALKER 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSTARPRIIT SKAPLLPQQT TPEQRYWRQY TSAQLVKEHN SVTHISFNPQ HPHDFAVTSS
70 80 90 100 110 120
TRVQIFSSRT RQVIKTFSRF KDVVYSASFR SDGKLLCAGD ATGLVSVYDS YNPRTILLSI
130 140 150 160 170 180
NASTHPTHVT KFHTQDNKIL ATASDDRVTR LWDISNAYEP QLELTGATDY VRTLSFIPAA
190 200 210 220 230 240
PHLVATGSYD GLIRLYDTRS SGSTPIYSLN HDQPVENVIA VSPTQIVSCG GNNFKVWDLT
250 260 270 280 290 300
SNKKLYERGN FNKAVTCLDY VENFDSPMQS ALIASSLDGH VKVFDPLDNF QVKFGWKFSG
310 320 330 340 350 360
PVLSCAVSPS TAQGNRHLVA GLSSGLLAIR TKKKEKRSSD KENAPASFNK NAKSNNFQRM
370 380 390 400 410 420
MRGSEYQGDQ EHIIHNDKVR SQRRMRAFER NINQFKWSEA LDNAFVPGMA KELTLTVLQE
430 440 450 460 470 480
LRKRGKVRVA LYGRDESTLE PLLNWCLKGI EDVRSASIVA DWVAVVLELY GNTLESSPVL
490 500 510
QELMIDLKTK VRHEIHKSKE AQRIEGMLQL LTS