A2RRU3

PR
Gene name
Utp15
Protein name
U3 small nucleolar RNA-associated protein 15 homolog
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:310019
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2RRU3

Entry ID Method Resolution Chain Position Source
AF-A2RRU3-F1 Predicted AlphaFoldDB

1 variants for A2RRU3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3319342507 517 S>A No EVA

No associated diseases with A2RRU3

7 regional properties for A2RRU3

Type Name Position InterPro Accession
repeat WD40 repeat 31 - 66 IPR001680-1
repeat WD40 repeat 69 - 108 IPR001680-2
repeat WD40 repeat 111 - 193 IPR001680-3
repeat WD40 repeat 196 - 233 IPR001680-4
repeat WD40 repeat 237 - 317 IPR001680-5
domain U3 small nucleolar RNA-associated protein 15, C-terminal 344 - 490 IPR018983
conserved_site WD40 repeat, conserved site 137 - 151 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Found predominantly at the fibrillar center
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
positive regulation of rRNA processing Any process that activates or increases the frequency, rate or extent of rRNA processing.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04305 UTP15 U3 small nucleolar RNA-associated protein 15 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9BVA0 KATNB1 Katanin p80 WD40 repeat-containing subunit B1 Homo sapiens (Human) PR
Q8BG40 Katnb1 Katanin p80 WD40 repeat-containing subunit B1 Mus musculus (Mouse) PR
Q8C7V3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Mus musculus (Mouse) PR
O82266 SWA1 Protein SLOW WALKER 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGYKPVVIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS
70 80 90 100 110 120
RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE DGVVQLFDIS GRAPLRQFEG
130 140 150 160 170 180
HTKAVHTVDF TADKYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF
190 200 210 220 230 240
VTGSYDHTVK MFDARTNKNV LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL
250 260 270 280 290 300
LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKIYSTTSY KVVHSFDYAA SILSLALSHQ
310 320 330 340 350 360
DETVVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKIYTKQRDD IVVTRPAKKH
370 380 390 400 410 420
LEWYDRDLKS FRISKALDRV LEPNCVIKTP EVTVSIIKEL NRRGVLANAL AGRDEKEITR
430 440 450 460 470 480
VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSSVVD KKFIVLQGLV EKEIDYQREL
490 500 510 520
LETLGMMDML FATMTRNGSA PVWEHVPAEL PEEKTESPRQ PSDTDKNS