Q8BG40

PR
Gene name
Katnb1
Protein name
Katanin p80 WD40 repeat-containing subunit B1
Names
Katanin p80 subunit B1, p80 katanin
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74187
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q8BG40

Entry ID Method Resolution Chain Position Source
5LB7 X-ray 150 A PDB
5NBT X-ray 240 A A/C 481-658 PDB
5OW5 X-ray 170 A A/C 481-658 PDB
6GZC X-ray 200 A A/C 481-658 PDB
AF-Q8BG40-F1 Predicted AlphaFoldDB

35 variants for Q8BG40

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389000953 23 V>L No EVA
rs3389007407 46 N>S No EVA
rs3389008951 48 W>C No EVA
rs3388977918 73 T>I No EVA
rs3388977924 76 E>V No EVA
rs3389003961 90 W>R No EVA
rs3388991096 105 K>N No EVA
rs3389002592 123 G>S No EVA
rs3389008880 148 Q>L No EVA
rs3388996394 149 A>V No EVA
rs3388971825 178 A>D No EVA
rs3389003995 195 V>M No EVA
rs3388952682 230 E>K No EVA
rs3389000841 246 L>W No EVA
rs3388996441 260 E>A No EVA
rs3388991077 308 T>S No EVA
rs232236791 319 N>S No EVA
rs3399557270 443 S>* No EVA
rs3399538877 445 M>V No EVA
rs232510615 456 D>A No EVA
rs3388979690 461 T>S No EVA
rs3388996411 509 H>L No EVA
rs3389004234 533 A>T No EVA
rs3388996425 535 N>K No EVA
rs3389003949 542 D>G No EVA
rs3388996450 548 N>K No EVA
rs3388999715 557 D>N No EVA
rs231820007 561 T>I No EVA
rs3399304127 588 I>T No EVA
rs3389002853 597 T>P No EVA
rs3389004270 598 D>E No EVA
rs3389004030 604 P>S No EVA
rs3399195906 611 S>R No EVA
rs3399195920 612 R>L No EVA
rs3388971785 639 L>S No EVA

No associated diseases with Q8BG40

8 regional properties for Q8BG40

Type Name Position InterPro Accession
repeat WD40 repeat 9 - 258 IPR001680
conserved_site WD40 repeat, conserved site 120 - 134 IPR019775-1
conserved_site WD40 repeat, conserved site 162 - 176 IPR019775-2
conserved_site WD40 repeat, conserved site 204 - 218 IPR019775-3
repeat G-protein beta WD-40 repeat 120 - 134 IPR020472-1
repeat G-protein beta WD-40 repeat 162 - 176 IPR020472-2
repeat G-protein beta WD-40 repeat 204 - 218 IPR020472-3
domain Katanin p80 subunit, C-terminal 496 - 654 IPR028021

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle pole
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, spindle
  • Predominantly cytoplasmic
  • Localized to the interphase centrosome and mitotic spindle poles (By similarity)
  • Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
katanin complex A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

4 GO annotations of molecular function

Name Definition
ATPase regulator activity Binds to and modulates the activity of an ATP hydrolysis activity.
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

8 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule.
microtubule severing The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends.
mitotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.
negative regulation of microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
positive regulation of cell death Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
positive regulation of microtubule depolymerization Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BVA0 KATNB1 Katanin p80 WD40 repeat-containing subunit B1 Homo sapiens (Human) PR
Q8C7V3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Mus musculus (Mouse) PR
Q9CWJ3 Katnbl1 KATNB1-like protein 1 Mus musculus (Mouse) PR
A2RRU3 Utp15 U3 small nucleolar RNA-associated protein 15 homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT
70 80 90 100 110 120
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV
130 140 150 160 170 180
ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK
190 200 210 220 230 240
MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN
250 260 270 280 290 300
PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV
310 320 330 340 350 360
DLTRVTRTGT VTQDPVQANQ PLTQQTPNPG VSLRRIYERP STTCSKPQRV KHNSESERRS
370 380 390 400 410 420
PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATVKEVSKP
430 440 450 460 470 480
SPAMDVQLPQ LPVPNLEVPA RPSVMTSTPA PKGEPDIIPA TRNEPIGLKA SDFLPAVKVP
490 500 510 520 530 540
QQAELVDEDA MSQIRKGHDT MFVVLTSRHK NLDTVRAVWT TGDIKTSVDS AVAINDLSVV
550 560 570 580 590 600
VDLLNIVNQK ASLWKLDLCT TVLPQIEKLL QSKYESYVQT GCTSLKLILQ RFLPLITDIL
610 620 630 640 650
AAPPSVGVDI SREERLHKCR LCFKQLKSIS GLVKSKSGLS GRHGSAFREL HLLMASLD