Q9CWJ3
Gene name |
Katnbl1 |
Protein name |
KATNB1-like protein 1 |
Names |
Katanin p80 subunit B-like 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72425 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CWJ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CWJ3-F1 | Predicted | AlphaFoldDB |
12 variants for Q9CWJ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1133558795 | 9 | K>N | No | EVA | |
| rs1132270747 | 10 | K>N | No | EVA | |
| rs1135266633 | 12 | N>Y | No | EVA | |
| rs215315956 | 72 | R>H | No | EVA | |
| rs251250730 | 87 | S>G | No | EVA | |
| rs3392046264 | 89 | G>D | No | EVA | |
| rs1134364264 | 100 | A>V | No | EVA | |
| rs1131786962 | 106 | P>H | No | EVA | |
| rs1135385526 | 106 | P>T | No | EVA | |
| rs3388579932 | 171 | S>I | No | EVA | |
| rs3388568793 | 220 | S>Y | No | EVA | |
| rs3388568791 | 275 | S>N | No | EVA |
No associated diseases with Q9CWJ3
1 regional properties for Q9CWJ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Glycosyl hydrolases family 1, N-terminal conserved site | 67 - 81 | IPR033132 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cleavage furrow | The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| katanin complex | A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| mitotic spindle pole | Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| positive regulation of cytoskeleton organization | Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFDTHHVKK | RNFSNSIDLP | RKRISNFTSK | NMKEVKRSPK | QLAAYISRTV | AQAVKSPEKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKVLYHRKLV | RRSFPNPCYK | TKQSPKSGGC | DMANKENELA | CAGHLPENLR | HDSRTFVINT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDSGSSQTES | PSSKYSGFFS | EVSQDHETMA | QVLFSRNLRL | NVALTFWRKR | SISELVAYLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIEDLGVVVD | CLPVLTNSLQ | EEKQYISLGC | CVDLLPLVKS | LLQSRFEEYV | IVGLNWLQAV |
| 250 | 260 | 270 | 280 | 290 | |
| IKRWWSELSS | TSEIISDGNI | KILKQQLSGL | WEQESHLTLV | PGYTGNIAKD | VDAYLLQLH |