AiPD: Autoinhibited Protein Database

Gene name	B4gat1
Protein name	Beta-1,4-glucuronyltransferase 1
Names	I-beta-1,3-N-acetylglucosaminyltransferase, iGnT, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:108902
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

6-91 (Predicted disordered autoinhibitory region) PR

6-91 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BWP8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389511067	5	Y>*	No	EVA
rs3389511723	5	Y>H	No	EVA
rs3389510515	13	Q>R	No	EVA
rs3389511072	46	F>L	No	EVA
rs3389528976	124	V>L	No	EVA
rs3389532113	147	P>A	No	EVA
rs3389517599	149	M>K	No	EVA
rs3389532100	165	A>V	No	EVA
rs3389425394	209	N>K	No	EVA
rs3408214824	214	N>T	No	EVA
rs3389518498	236	L>Q	No	EVA
rs3389528886	253	T>A	No	EVA
rs3389484036	255	L>M	No	EVA
rs3412796881	296	H>L	No	EVA
rs3389518726	308	P>S	No	EVA
rs3389521756	367	N>D	No	EVA
rs3406967459	371	L>Q	No	EVA
rs3389497160	372	V>I	No	EVA
rs3389526470	388	A>S	No	EVA
rs228644962	412	P>L	No	EVA

Type	Name	Position	InterPro Accession
domain	Galactosyltransferase, C-terminal	182 - 257	IPR027791
domain	Galactosyltransferase, N-terminal	84 - 175	IPR027995

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein	Localizes near the trans-Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
glucuronosyltransferase activity	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
metal ion binding	Binding to a metal ion.

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
protein glycosylation	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein O-linked mannosylation	The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5EA01	B4GAT1	Beta-1,4-glucuronyltransferase 1	Bos taurus (Bovine)	PR
Q5ZKI6	GXYLT1	Glucoside xylosyltransferase 1	Gallus gallus (Chicken)	PR
Q66PG4	LARGE2	Xylosyl- and glucuronyltransferase LARGE2s	Gallus gallus (Chicken)	PR
A0PJZ3	GXYLT2	Glucoside xylosyltransferase 2	Homo sapiens (Human)	PR
O43505	B4GAT1	Beta-1,4-glucuronyltransferase 1	Homo sapiens (Human)	PR
Q810K9	Gxylt2	Glucoside xylosyltransferase 2	Mus musculus (Mouse)	PR
Q21389	lge-1	Glycosyltransferase-like protein LARGE	Caenorhabditis elegans	PR
L7YAI7	b4gat1	Beta-1,4-glucuronyltransferase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR