Q66PG4
Gene name |
LARGE2 |
Protein name |
Xylosyl- and glucuronyltransferase LARGE2s |
Names |
Glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:423200 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q66PG4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q66PG4-F1 | Predicted | AlphaFoldDB |
No variants for Q66PG4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q66PG4 | |||||
No associated diseases with Q66PG4
No regional properties for Q66PG4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q66PG4 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| metal ion binding | Binding to a metal ion. |
| xylosyltransferase activity | Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein O-linked mannosylation | The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA01 | B4GAT1 | Beta-1,4-glucuronyltransferase 1 | Bos taurus (Bovine) | PR |
| Q5ZKI6 | GXYLT1 | Glucoside xylosyltransferase 1 | Gallus gallus (Chicken) | PR |
| O43505 | B4GAT1 | Beta-1,4-glucuronyltransferase 1 | Homo sapiens (Human) | PR |
| A0PJZ3 | GXYLT2 | Glucoside xylosyltransferase 2 | Homo sapiens (Human) | PR |
| Q810K9 | Gxylt2 | Glucoside xylosyltransferase 2 | Mus musculus (Mouse) | PR |
| Q8BWP8 | B4gat1 | Beta-1,4-glucuronyltransferase 1 | Mus musculus (Mouse) | PR |
| Q21389 | lge-1 | Glycosyltransferase-like protein LARGE | Caenorhabditis elegans | PR |
| L7YAI7 | b4gat1 | Beta-1,4-glucuronyltransferase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLCSWRVKLK | LLLATITLAV | LLSWLYLFVG | SLEYGRFLLL | PPCLGEQPSR | DVEREALASQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRRVEEENQQ | LRMQLGQVQA | EGSDGNPQWA | ASAEDGPPLG | GERNNRTACP | EQRMVRKCEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHVAIVCAGH | NASRDVVTLV | KSILFHRKNP | LHFHFITDSV | AHQILQTLFQ | SWMVPSIHVS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FYNADDLKPE | VSWIPNKHYS | GIYGLMKLTL | TKALPSNLSK | VIVLDTDITF | ATDIAELWAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGKFSEKQVI | GLVENQSDWY | LGNLWKNHKP | WPALGRGFNT | GVILLLLDRL | RRLGWEQMWR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTAERELMSM | LSTSLADQDI | FNAVIKQNPA | LVYRLPCFWN | VQLSDHTRSE | LCYTEVSDLK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VIHWNSPKKL | RVKNKHVEFF | RNLYLTFLEY | DGNLLRRELF | GCASLPSPPS | DQLQQALEEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DEDDPCYDFR | RQHLTQHRVH | LFFLQYEFLA | LPNPTDVTLV | AQLSMDRLQM | LEAICKHWAG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PISLALYMSD | AEAQQFLRYA | QASEVLSARR | NVAYHIVYKE | GQFYPINLLR | NVALANTQTP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YVFLTDIDFL | PMYGLYDYLR | NSIQQLELPH | RKAALIVPAF | ETLHYRLTFP | KSKAELLSML |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DMGSLYTFRY | HVWPKGHAPT | DYAKWRTATV | PYRVAWQPDF | EPYVVVRRDC | PKYDQRFVGF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GWNKVSHIME | LDAQEYELLV | LPNAFMIHMP | HAPSFDISKF | RLSAGYRGCL | QTLREEFHQD |
| 730 | |||||
| LSRKYGAAAL | KYLTAERNL |