Q5EA01
PR
Gene name |
B4GAT1 |
Protein name |
Beta-1,4-glucuronyltransferase 1 |
Names |
I-beta-1,3-N-acetylglucosaminyltransferase, iGnT, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:618055 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5EA01
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5EA01-F1 | Predicted | AlphaFoldDB |
166 variants for Q5EA01
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs464202773 | 2 | Q>* | No | EVA | |
| rs478636186 | 3 | M>I | No | EVA | |
| rs447282382 | 3 | M>T | No | EVA | |
| rs461699257 | 4 | S>A | No | EVA | |
| rs461699257 | 4 | S>T | No | EVA | |
| rs482886051 | 5 | Y>S | No | EVA | |
| rs438970465 | 6 | A>P | No | EVA | |
| rs462760518 | 13 | Q>P | No | EVA | |
| rs439367635 | 18 | A>P | No | EVA | |
| rs471966461 | 29 | Y>F | No | EVA | |
| rs458161953 | 32 | L>P | No | EVA | |
| rs455547208 | 52 | S>F | No | EVA | |
| rs435867610 | 54 | R>G | No | EVA | |
| rs476693432 | 58 | Q>K | No | EVA | |
| rs456747971 | 59 | V>F | No | EVA | |
| rs433369689 | 60 | K>E | No | EVA | |
| rs464304482 | 62 | Q>* | No | EVA | |
| rs447304295 | 64 | R>L | No | EVA | |
| rs433614326 | 65 | T>P | No | EVA | |
| rs468189790 | 66 | A>P | No | EVA | |
| rs448050582 | 66 | A>V | No | EVA | |
| rs462828084 | 68 | A>G | No | EVA | |
| rs482947593 | 68 | A>S | No | EVA | |
| rs445865431 | 69 | S>C | No | EVA | |
| rs477257010 | 71 | G>S | No | EVA | |
| rs441316768 | 75 | A>P | No | EVA | |
| rs462015174 | 82 | Y>F | No | EVA | |
| rs441947190 | 84 | G>S | No | EVA | |
| rs433426889 | 86 | L>R | No | EVA | |
| rs471175153 | 87 | K>E | No | EVA | |
| rs454278322 | 88 | T>N | No | EVA | |
| rs433676263 | 91 | D>A | No | EVA | |
| rs468251287 | 95 | V>G | No | EVA | |
| rs437585003 | 102 | S>I | No | EVA | |
| rs468965374 | 104 | D>E | No | EVA | |
| rs445898924 | 105 | N>S | No | EVA | |
| rs466744848 | 108 | H>L | No | EVA | |
| rs478942472 | 112 | L>R | No | EVA | |
| rs462078447 | 113 | L>W | No | EVA | |
| rs442008676 | 114 | E>G | No | EVA | |
| rs482834463 | 115 | R>G | No | EVA | |
| rs462910684 | 115 | R>P | No | EVA | |
| rs439913854 | 116 | W>R | No | EVA | |
| rs471268024 | 117 | E>G | No | EVA | |
| rs454276617 | 118 | G>V | No | EVA | |
| rs454635146 | 120 | L>M | No | EVA | |
| rs437651120 | 120 | L>P | No | EVA | |
| rs454635146 | 120 | L>V | No | EVA | |
| rs468976707 | 123 | S>W | No | EVA | |
| rs452049045 | 126 | A>P | No | EVA | |
| rs432307570 | 128 | T>P | No | EVA | |
| rs466869169 | 131 | E>D | No | EVA | |
| rs446647629 | 132 | A>S | No | EVA | |
| rs467360095 | 134 | L>R | No | EVA | |
| rs448494967 | 136 | T>S | No | EVA | |
| rs483137462 | 138 | L>R | No | EVA | |
| rs439564667 | 139 | T>S | No | EVA | |
| rs477784167 | 140 | Y>S | No | EVA | |
| rs440704022 | 141 | A>G | No | EVA | |
| rs460845369 | 141 | A>S | No | EVA | |
| rs475205649 | 142 | L>Q | No | EVA | |
| rs455103521 | 144 | S>N | No | EVA | |
| rs444163575 | 145 | H>D | No | EVA | |
| rs475529876 | 146 | C>F | No | EVA | |
| rs475529876 | 146 | C>S | No | EVA | |
| rs452039749 | 148 | D>Y | No | EVA | |
| rs431957024 | 153 | V>F | No | EVA | |
| rs453095818 | 154 | A>P | No | EVA | |
| rs436204652 | 156 | H>P | No | EVA | |
| rs438118357 | 158 | V>G | No | EVA | |
| rs450564262 | 158 | V>M | No | EVA | |
| rs446042915 | 159 | C>G | No | EVA | |
| rs477427272 | 159 | C>S | No | EVA | |
| rs460490309 | 160 | P>A | No | EVA | |
| rs481684468 | 161 | S>A | No | EVA | |
| rs481684468 | 161 | S>P | No | EVA | |
| rs444604825 | 163 | Y>S | No | EVA | |
| rs475554907 | 164 | E>G | No | EVA | |
| rs438443542 | 169 | D>A | No | EVA | |
| rs452761455 | 171 | R>P | No | EVA | |
| rs436267606 | 175 | E>G | No | EVA | |
| rs473886783 | 176 | F>V | No | EVA | |
| rs436984614 | 178 | L>V | No | EVA | |
| rs1117275437 | 180 | R>L | No | EVA | |
| rs469495655 | 183 | Q>R | No | EVA | |
| rs446131575 | 185 | V>G | No | EVA | |
| rs432448552 | 193 | A>G | No | EVA | |
| rs466987018 | 194 | Q>H | No | EVA | |
| rs446850969 | 195 | P>A | No | EVA | |
| rs461638030 | 198 | N>D | No | EVA | |
| rs451036071 | 213 | R>S | No | EVA | |
| rs482481712 | 215 | L>M | No | EVA | |
| rs438504520 | 220 | A>D | No | EVA | |
| rs459216852 | 222 | Y>* | No | EVA | |
| rs473946810 | 228 | V>E | No | EVA | |
| rs473946810 | 228 | V>G | No | EVA | |
| rs457222024 | 229 | D>N | No | EVA | |
| rs437037254 | 229 | D>V | No | EVA | |
| rs471632730 | 231 | V>G | No | EVA | |
| rs451361190 | 233 | S>N | No | EVA | |
| rs432496141 | 233 | S>R | No | EVA | |
| rs467049607 | 234 | E>K | No | EVA | |
| rs453379364 | 234 | E>V | No | EVA | |
| rs436369219 | 240 | L>R | No | EVA | |
| rs467731304 | 243 | M>L | No | EVA | |
| rs451185454 | 243 | M>T | No | EVA | |
| rs482556056 | 247 | S>R | No | EVA | |
| rs465590425 | 249 | Q>E | No | EVA | |
| rs445375621 | 249 | Q>H | No | EVA | |
| rs479342711 | 252 | G>V | No | EVA | |
| rs442416090 | 255 | L>V | No | EVA | |
| rs480026061 | 258 | P>R | No | EVA | |
| rs463289606 | 261 | E>* | No | EVA | |
| rs443530231 | 262 | I>V | No | EVA | |
| rs451513695 | 267 | R>H | No | EVA | |
| rs441041280 | 268 | M>I | No | EVA | |
| rs473534518 | 270 | M>R | No | EVA | |
| rs453440025 | 271 | N>H | No | EVA | |
| rs436432834 | 271 | N>K | No | EVA | |
| rs467790930 | 273 | N>I | No | EVA | |
| rs457236268 | 273 | N>K | No | EVA | |
| rs465601328 | 277 | Q>H | No | EVA | |
| rs445470599 | 281 | V>G | No | EVA | |
| rs479805098 | 282 | G>R | No | EVA | |
| rs466160152 | 283 | E>D | No | EVA | |
| rs448898985 | 284 | V>E | No | EVA | |
| rs480087224 | 293 | T>P | No | EVA | |
| rs443178008 | 301 | Y>C | No | EVA | |
| rs443178008 | 301 | Y>F | No | EVA | |
| rs463402066 | 301 | Y>H | No | EVA | |
| rs443178008 | 301 | Y>S | No | EVA | |
| rs457957383 | 305 | V>A | No | EVA | |
| rs478197874 | 305 | V>L | No | EVA | |
| rs472391075 | 321 | W>G | No | EVA | |
| rs455501239 | 323 | D>E | No | EVA | |
| rs442958871 | 324 | P>L | No | EVA | |
| rs457363240 | 325 | W>G | No | EVA | |
| rs437177027 | 326 | E>G | No | EVA | |
| rs472167439 | 327 | P>A | No | EVA | |
| rs451899969 | 328 | F>C | No | EVA | |
| rs435003713 | 328 | F>L | No | EVA | |
| rs466221267 | 329 | Y>C | No | EVA | |
| rs449381596 | 330 | V>L | No | EVA | |
| rs449706920 | 331 | A>G | No | EVA | |
| rs469866030 | 331 | A>S | No | EVA | |
| rs477866374 | 333 | G>R | No | EVA | |
| rs457694640 | 334 | K>* | No | EVA | |
| rs447606416 | 334 | K>R | No | EVA | |
| rs447606416 | 334 | K>T | No | EVA | |
| rs478870276 | 335 | V>G | No | EVA | |
| rs441817753 | 336 | P>A | No | EVA | |
| rs463806394 | 337 | T>A | No | EVA | |
| rs463806394 | 337 | T>P | No | EVA | |
| rs471774285 | 338 | F>C | No | EVA | |
| rs435089456 | 339 | D>E | No | EVA | |
| rs451565593 | 339 | D>G | No | EVA | |
| rs472688529 | 341 | R>C | No | EVA | |
| rs455825313 | 342 | F>V | No | EVA | |
| rs470357686 | 344 | Q>R | No | EVA | |
| rs449705686 | 348 | N>K | No | EVA | |
| rs469166859 | 359 | A>G | No | EVA | |
| rs441229619 | 379 | V>G | No | EVA | |
| rs478817473 | 408 | Y>S | No | EVA | |
| rs461951514 | 410 | D>A | No | EVA | |
| rs476925157 | 413 | R>G | No | EVA | |
| rs456704424 | 413 | R>H | No | EVA |
No associated diseases with Q5EA01
No regional properties for Q5EA01
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5EA01 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| protein O-linked mannosylation | The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZKI6 | GXYLT1 | Glucoside xylosyltransferase 1 | Gallus gallus (Chicken) | PR |
| Q66PG4 | LARGE2 | Xylosyl- and glucuronyltransferase LARGE2s | Gallus gallus (Chicken) | PR |
| A0PJZ3 | GXYLT2 | Glucoside xylosyltransferase 2 | Homo sapiens (Human) | PR |
| O43505 | B4GAT1 | Beta-1,4-glucuronyltransferase 1 | Homo sapiens (Human) | PR |
| Q810K9 | Gxylt2 | Glucoside xylosyltransferase 2 | Mus musculus (Mouse) | PR |
| Q8BWP8 | B4gat1 | Beta-1,4-glucuronyltransferase 1 | Mus musculus (Mouse) | PR |
| Q21389 | lge-1 | Glycosyltransferase-like protein LARGE | Caenorhabditis elegans | PR |
| L7YAI7 | b4gat1 | Beta-1,4-glucuronyltransferase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQMSYAIRCA | FYQLLLAALM | LVAMLQLLYL | SLLSGLHGQE | EQDQYFEFFP | PSPRSVDQVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQLRTALASG | GVLDASGDYR | VYRGLLKTTM | DPNDVILATH | ASVDNLLHLS | GLLERWEGPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVSVFAATKE | EAQLATVLTY | ALSSHCPDMR | ARVAMHLVCP | SRYEAAVPDP | REPGEFALLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SCQEVFDKLA | RVAQPGVNYA | LGTNVSYPNN | LLRNLAREGA | NYALVIDVDM | VPSEGLWRSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| REMLDQSKQW | AGTALVVPAF | EIRRARRMPM | NKNELLQLYQ | VGEVRPFYYG | LCTPCQAPTN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YSRWVNLPEE | TLLRPAYVVP | WQDPWEPFYV | AGGKVPTFDE | RFRQYGFNRI | SQACELHVAG |
| 370 | 380 | 390 | 400 | 410 | |
| FDFEVLNEGF | LVHKGFKEVL | KFHPQKEAEN | QHNKILYRQF | KQELKAKYPD | SPRHC |