Q810K9

PR
Gene name
Gxylt2 (Glt8d4)
Protein name
Glucoside xylosyltransferase 2
Names
Glycosyltransferase 8 domain-containing protein 4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:232313
EC number
2.4.2.42: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q810K9

Entry ID Method Resolution Chain Position Source
AF-Q810K9-F1 Predicted AlphaFoldDB

16 variants for Q810K9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254838277 21 A>V No EVA
rs3397112260 99 T>I No EVA
rs3388837184 119 G>V No EVA
rs239544498 120 N>T No EVA
rs3388844260 142 F>S No EVA
rs3396872289 146 T>R No EVA
rs3397108362 146 T>S No EVA
rs3388850591 235 S>P No EVA
rs3388848201 254 S>N No EVA
rs3388827135 255 R>L No EVA
rs3388844222 292 G>V No EVA
rs3388842150 351 E>K No EVA
rs3388843535 365 G>C No EVA
rs3388851673 365 G>D No EVA
rs231508542 438 M>L No EVA
rs231508542 438 M>V No EVA

No associated diseases with Q810K9

No regional properties for Q810K9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q810K9

Functions

Description
EC Number 2.4.2.42 Pentosyltransferases
Subcellular Localization
  • Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity Catalyzes the reaction: UDP-alpha-D-xylose + -3-O-(beta-D-glucosyl)-L-serine <=> UDP + -3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine.
UDP-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.

1 GO annotations of biological process

Name Definition
O-glycan processing The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EA01 B4GAT1 Beta-1,4-glucuronyltransferase 1 Bos taurus (Bovine) PR
Q5ZKI6 GXYLT1 Glucoside xylosyltransferase 1 Gallus gallus (Chicken) PR
Q66PG4 LARGE2 Xylosyl- and glucuronyltransferase LARGE2s Gallus gallus (Chicken) PR
O43505 B4GAT1 Beta-1,4-glucuronyltransferase 1 Homo sapiens (Human) PR
A0PJZ3 GXYLT2 Glucoside xylosyltransferase 2 Homo sapiens (Human) PR
Q8BWP8 B4gat1 Beta-1,4-glucuronyltransferase 1 Mus musculus (Mouse) PR
Q21389 lge-1 Glycosyltransferase-like protein LARGE Caenorhabditis elegans PR
L7YAI7 b4gat1 Beta-1,4-glucuronyltransferase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKLRSKAAAL LLLALAVLLL ALLSLRARRD PEPPGFPARP EAAPQRRHAP VPTLPPEPRA
70 80 90 100 110 120
FPGAAGRRSP RRQPPRLRPR AGRPRAASRE KLARRPGETR SLHSVPPELW IHLAVVACGN
130 140 150 160 170 180
RLEETLVMLK SAVLFSHRKM RFHIFTEDAL KPEFDKQLRQ WPDSYTKKFE HRLYPITFSV
190 200 210 220 230 240
GNPQEWKKLF KPCAAQRLFL PAILKDVDSL LYVDTDVLFL RPVDDIWKLL RQFNSTQLAA
250 260 270 280 290 300
MAPEHEIPKI GWYSRFARHP FYGSAGVNSG VMLMNLTRIR NTQFKNSLIP AGLAWEEMLL
310 320 330 340 350 360
PLYQKYKSAI TWGDQDLLNI IFYYNPECLY VFPCQWNYRP DHCMYGSNCK EAEREGVSVL
370 380 390 400 410 420
HGNRGVYHDD KQPTFRALYE AIRDFPFQDN LFQSMYYPLQ LKFLETVHTL CGRIPQVFLK
430 440
QIEKTMRRAY EKHVIIHMGP NPMS