AiPD: Autoinhibited Protein Database

Gene name	Iqcg (Drc9)
Protein name	Dynein regulatory complex protein 9
Names	IQ domain-containing protein G
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:69707
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

65-139 (Predicted disordered autoinhibitory region) PR

65-139 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q80W32-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389405741	9	V>M	No	EVA
rs212794584	10	E>G	No	EVA
rs266189851	49	I>T	No	EVA
rs233218159	69	D>N	No	EVA
rs240131688	89	T>I	No	EVA
rs4171104	99	M>T	No	EVA
rs231838466	101	T>I	No	EVA
rs3389419394	116	S>P	No	EVA
rs263423660	130	F>L	No	EVA
rs3389412369	130	F>Y	No	EVA
rs3389374347	160	N>T	No	EVA
rs3389329061	235	Q>K	No	EVA
rs3389329080	261	K>Q	No	EVA
rs3389411473	268	E>K	No	EVA
rs3389406429	269	L>F	No	EVA
rs3389329040	274	I>T	No	EVA
rs3389374359	281	T>I	No	EVA
rs32569179	336	V>A	No	EVA
rs3389404621	370	D>G	No	EVA
rs3389393137	403	D>N	No	EVA
rs3389411510	413	K>R	No	EVA
rs3389428887	415	K>T	No	EVA

Type	Name	Position	InterPro Accession
binding_site	IQ motif, EF-hand binding site	372 - 401	IPR000048

		Description
EC Number
Subcellular Localization	Cytoplasm Cell projection, cilium, flagellum Cell projection, cilium Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, flagellum axoneme	First detected in the cytoplasm of pachytene spermatocytes Colocalizes with alpha-tubulin at the manchette in developing spermatids Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa Detected in cilia in trachea and oviduct
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
manchette	A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
sperm flagellum	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

Name	Definition
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.

Name	Definition
cilium organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
sperm axoneme assembly	The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatid development	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9V2	IQCG	Dynein regulatory complex protein 9	Bos taurus (Bovine)	PR
Q9H095	IQCG	Dynein regulatory complex protein 9	Homo sapiens (Human)	PR
Q9D3V1	Iqcd	Dynein regulatory complex protein 10	Mus musculus (Mouse)	PR
Q5PQQ6	Iqcg	Dynein regulatory complex protein 9	Rattus norvegicus (Rat)	PR
Q5XIR6	Iqcd	Dynein regulatory complex protein 10	Rattus norvegicus (Rat)	PR