Q5PQQ6

PR
Gene name
Iqcg (Drc9)
Protein name
Dynein regulatory complex protein 9
Names
IQ domain-containing protein G
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:363796
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

368-419 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5PQQ6

Entry ID Method Resolution Chain Position Source
AF-Q5PQQ6-F1 Predicted AlphaFoldDB

No variants for Q5PQQ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5PQQ6

No associated diseases with Q5PQQ6

1 regional properties for Q5PQQ6

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 371 - 400 IPR000048

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, cilium, flagellum
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, flagellum axoneme
  • First detected in the cytoplasm of pachytene spermatocytes
  • Colocalizes with alpha-tubulin at the manchette in developing spermatids
  • Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa
  • Detected in cilia in trachea and oviduct
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

2 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.

3 GO annotations of biological process

Name Definition
cilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2T9V2 IQCG Dynein regulatory complex protein 9 Bos taurus (Bovine) PR
Q9H095 IQCG Dynein regulatory complex protein 9 Homo sapiens (Human) PR
Q80W32 Iqcg Dynein regulatory complex protein 9 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEGEELETTG SLSEVFQPEV TMAVTGEPPK PAEEELEEEE EETSPEVIDT LSLLDVLRVS
70 80 90 100 110 120
AIMEDIIDQL SILGYIIPVQ YERRQSLSQK TSHEGAPMVP STPKISASLI AKDKPVVSDS
130 140 150 160 170 180
KQRGQDFFFK KATKQTTMTL ETMRKIQNDR QYFSDVIANA MMEMQACGSF SSLLEALGKE
190 200 210 220 230 240
RDAKMNFHDV ITREGKGRKQ IKSLQKQLVD VKRERQMQVQ NGNEYIAHLR DQLQEVKAKT
250 260 270 280 290 300
NLENLYMKRN TELQVSQTQK KCNRAEELLL EEIEKLRLKT EEENRVHMEI EMFLRNQQQK
310 320 330 340 350 360
LEEKLEFWME KFDKDTEAKQ NELNALKAAK ASDLAHLQDL AKMIREYEQV IIEDRLEKEK
370 380 390 400 410
TRKKLEQDDL ELRSIVKLQA WWRGTVVRRE IGSFKMPKKE KDDSKDAKGK EKDKRRGKK