Q7YRZ2

PR
Gene name
APTX
Protein name
Aprataxin
Names
Forkhead-associated domain histidine triad-like protein, FHA-HIT
Species
Bos taurus (Bovine)
KEGG Pathway
bta:359714
EC number
3.6.1.71: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-197 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YRZ2

Entry ID Method Resolution Chain Position Source
AF-Q7YRZ2-F1 Predicted AlphaFoldDB

No variants for Q7YRZ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7YRZ2

No associated diseases with Q7YRZ2

No regional properties for Q7YRZ2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7YRZ2

Functions

Description
EC Number 3.6.1.71 In phosphorus-containing anhydrides
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus, nucleolus
  • Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage
  • Colocalizes with MDC1 at sites of DNA double-strand breaks
  • Interaction with NCL is required for nucleolar localization (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
DNA 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus.
DNA-3'-diphospho-5'-guanosine diphosphatase Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP.
double-stranded RNA binding Binding to double-stranded RNA.
metal ion binding Binding to a metal ion.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.
single-strand break-containing DNA binding Binding to damaged DNA containing single-strand breaks (SSBs).
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
single strand break repair The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96T60 PNKP Bifunctional polynucleotide phosphatase/kinase Homo sapiens (Human) PR
Q7Z2E3 APTX Aprataxin Homo sapiens (Human) PR
Q9JLV6 Pnkp Bifunctional polynucleotide phosphatase/kinase Mus musculus (Mouse) PR
Q7TQC5 Aptx Aprataxin Mus musculus (Mouse) PR
Q7YRZ1 APTX Aprataxin Sus scrofa (Pig) PR
Q19683 F21D5.5 Uncharacterized protein F21D5.5 Caenorhabditis elegans PR
10 20 30 40 50 60
MSNVSLSASA VSRVMMRVCW LVRQDNRHQR IKLPHLETVM VGRSPETKIA DKKCSRQQVQ
70 80 90 100 110 120
LKAECNKGYV KVKQVGVNPT SIDSVIIGKD QEVKLQPGQV LYLVNELYPY IIEFEEETKS
130 140 150 160 170 180
PGLESHRKRK RSGSSDPTER GADPEAEPST GLEPGSNPHQ CSVPPKKEKD ASIKKESLGH
190 200 210 220 230 240
WSQGLKISME DPKMQVYKDE QVVVIKDKYP KARFHWLVLP WASISSLKAV TREHLELLRH
250 260 270 280 290 300
MHAVGEKVIA DFAGSSKFRF RLGYHAIPSM SHVHLHVISQ DFDSPCLKNK KHWNSFNTEY
310 320 330 340 350
FLESQAVIEM VQEAGRVTVR DGMPELLKLP LRCHECQQLL PSIPQLKEHL RKHWSK