Q19683
Gene name |
F21D5.5 |
Protein name |
Uncharacterized protein F21D5.5 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F21D5.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q19683
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q19683-F1 | Predicted | AlphaFoldDB |
No variants for Q19683
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q19683 | |||||
No associated diseases with Q19683
2 regional properties for Q19683
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Argininosuccinate synthase, conserved site | 10 - 18 | IPR018223-1 |
| conserved_site | Argininosuccinate synthase, conserved site | 117 - 128 | IPR018223-2 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| polydeoxyribonucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. |
| polynucleotide 3'-phosphatase activity | Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| nucleotide phosphorylation | The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7YRZ2 | APTX | Aprataxin | Bos taurus (Bovine) | PR |
| Q7Z2E3 | APTX | Aprataxin | Homo sapiens (Human) | PR |
| Q96T60 | PNKP | Bifunctional polynucleotide phosphatase/kinase | Homo sapiens (Human) | PR |
| Q7TQC5 | Aptx | Aprataxin | Mus musculus (Mouse) | PR |
| Q9JLV6 | Pnkp | Bifunctional polynucleotide phosphatase/kinase | Mus musculus (Mouse) | PR |
| Q7YRZ1 | APTX | Aprataxin | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRAMDGAKN | EAKKSKDTDL | FGRPLKKTGS | WESKDNGDLM | IFTHSECEGK | EKIAAFDMDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLIKTKSGKV | FPTNCQDWQL | LYDSIPSDFK | KLHSDGFKIV | IFTNQKGIHA | GKVDRNEFRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KIEAIVGKLG | IPVQAFVSVA | GGHYRKPCVG | MWNELKLRND | EVEINEKESI | FVGDAAGRIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTSRPKKDHS | YADRFFAANV | GVKFQTPEEF | FGKSKVDEPW | GPPNFDPKNL | FSEEITELEP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HDAQLKSSEK | EIILMVGFPG | SGKSTFAKML | GHQHDYKIVN | RDTIGTWQKC | VAATRSYLAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKSVVIDNTS | PDLESRKRYI | DVAKELGVPI | RCFEMNCSME | HAQHNIRFRV | LTDDNAAEIS |
| 370 | 380 | 390 | 400 | ||
| SMVLRIHKGK | YVEPTLSEGF | SQIVKVNFRP | KFEVEEHEKL | YKMYLIE |