Q7YRZ1
Gene name |
APTX |
Protein name |
Aprataxin |
Names |
Forkhead-associated domain histidine triad-like protein, FHA-HIT |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:387596 |
EC number |
3.6.1.71: In phosphorus-containing anhydrides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7YRZ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7YRZ1-F1 | Predicted | AlphaFoldDB |
No variants for Q7YRZ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7YRZ1 | |||||
No associated diseases with Q7YRZ1
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.1.71 | In phosphorus-containing anhydrides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA 5'-adenosine monophosphate hydrolase activity | Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. |
| DNA-3'-diphospho-5'-guanosine diphosphatase | Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP. |
| double-stranded RNA binding | Binding to double-stranded RNA. |
| metal ion binding | Binding to a metal ion. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
| single-strand break-containing DNA binding | Binding to damaged DNA containing single-strand breaks (SSBs). |
| single-stranded DNA binding | Binding to single-stranded DNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. |
| single strand break repair | The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7YRZ2 | APTX | Aprataxin | Bos taurus (Bovine) | PR |
| Q96T60 | PNKP | Bifunctional polynucleotide phosphatase/kinase | Homo sapiens (Human) | PR |
| Q7Z2E3 | APTX | Aprataxin | Homo sapiens (Human) | PR |
| Q9JLV6 | Pnkp | Bifunctional polynucleotide phosphatase/kinase | Mus musculus (Mouse) | PR |
| Q7TQC5 | Aptx | Aprataxin | Mus musculus (Mouse) | PR |
| Q19683 | F21D5.5 | Uncharacterized protein F21D5.5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNVSLSPSA | VSRIMTRVCW | LVRQDSRHQR | IKLPHLEAVI | VGRGPETKIT | DKKCSRQQVQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKAECNKGYV | KVKQVGVNPT | SIDSVIIGKD | QEMKLQPGQV | LHMVNELYPY | VIEFEEEAKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGLKTHRKRK | RSGNSDSVER | DASQEAKPST | GAEPGSNPSQ | CSVPPKKEKD | AATKKESLSH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WSQGLKISME | DPKMQVYKDD | QVVVIKDKYP | KARYHWLVLP | WASISSLKAV | TREHLELLRH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MHTVGEKVIA | DFAGSSKLRF | RLGYHAIPSM | SHVHLHVISQ | DFDSPCLKNK | KHWNSFNTEY |
| 310 | 320 | 330 | 340 | 350 | |
| FLESQAVIEM | VQEAGRVTVR | DGMPELLKLP | LRCHECQQLL | PSIPQLKEHL | RKHWPK |