Q6GYP7
PR
Gene name |
Ralgapa1 (Garnl1, Kiaa0884, Tulip1) |
Protein name |
Ral GTPase-activating protein subunit alpha-1 |
Names |
GAP-related-interacting partner to E12, GRIPE, GTPase-activating RapGAP domain-like 1, Tuberin-like protein 1, p240 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56784 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GYP7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GYP7-F1 | Predicted | AlphaFoldDB |
62 variants for Q6GYP7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389238893 | 44 | K>E | No | EVA | |
| rs3402650027 | 44 | K>N | No | EVA | |
| rs3389214229 | 140 | Q>R | No | EVA | |
| rs3389200660 | 141 | D>V | No | EVA | |
| rs3389236528 | 167 | P>H | No | EVA | |
| rs3389250736 | 170 | L>* | No | EVA | |
| rs48588981 | 179 | S>N | No | EVA | |
| rs3403299407 | 181 | Q>H | No | EVA | |
| rs3403299434 | 272 | I>T | No | EVA | |
| rs3403393592 | 299 | I>T | No | EVA | |
| rs3413058702 | 320 | S>T | No | EVA | |
| rs3389207910 | 339 | A>T | No | EVA | |
| rs3389207982 | 342 | S>N | No | EVA | |
| rs3389172977 | 354 | V>I | No | EVA | |
| rs48172756 | 357 | V>A | No | EVA | |
| rs3389238472 | 359 | K>R | No | EVA | |
| rs3389238165 | 373 | L>I | No | EVA | |
| rs3389242268 | 405 | R>I | No | EVA | |
| rs1132232546 | 461 | D>H | No | EVA | |
| rs1133945773 | 462 | I>R | No | EVA | |
| rs1133356251 | 465 | S>C | No | EVA | |
| rs3389253963 | 484 | E>* | No | EVA | |
| rs3389238881 | 491 | E>G | No | EVA | |
| rs3389249739 | 497 | S>R | No | EVA | |
| rs3413113946 | 525 | A>T | No | EVA | |
| rs3389225875 | 588 | V>I | No | EVA | |
| rs3389247547 | 608 | S>G | No | EVA | |
| rs249567531 | 608 | S>N | No | EVA | |
| rs3389233541 | 619 | L>P | No | EVA | |
| rs1132240503 | 717 | R>I | No | EVA | |
| rs1133963496 | 721 | R>L | No | EVA | |
| rs1133376405 | 725 | G>D | No | EVA | |
| rs247686918 | 764 | R>H | No | EVA | |
| rs3389249777 | 786 | H>N | No | EVA | |
| rs258783345 | 824 | N>S | No | EVA | |
| rs51655209 | 825 | S>T | No | EVA | |
| rs3389254025 | 955 | V>M | No | EVA | |
| rs3389233503 | 959 | T>S | No | EVA | |
| rs3389225894 | 1024 | H>R | No | EVA | |
| rs3403304746 | 1069 | G>S | No | EVA | |
| rs3389214199 | 1078 | M>L | No | EVA | |
| rs3389247558 | 1094 | W>R | No | EVA | |
| rs3389212724 | 1104 | L>F | No | EVA | |
| rs3389225879 | 1180 | L>H | No | EVA | |
| rs3389233526 | 1254 | H>Q | No | EVA | |
| rs3389243448 | 1415 | A>S | No | EVA | |
| rs3389242181 | 1421 | E>K | No | EVA | |
| rs3389253984 | 1519 | Y>F | No | EVA | |
| rs3389236580 | 1561 | L>M | No | EVA | |
| rs3389172992 | 1592 | S>L | No | EVA | |
| rs265747919 | 1641 | P>L | No | EVA | |
| rs245514171 | 1651 | A>T | No | EVA | |
| rs3389238173 | 1730 | E>V | No | EVA | |
| rs3402648956 | 1897 | L>W | No | EVA | |
| rs3403472521 | 1898 | R>K | No | EVA | |
| rs3402648901 | 1900 | L>Q | No | EVA | |
| rs3389207921 | 1955 | P>E | No | EVA | |
| rs3389242207 | 1963 | N>K | No | EVA | |
| rs3389238836 | 1966 | V>I | No | EVA | |
| rs3389247510 | 1983 | K>T | No | EVA | |
| rs3403416014 | 2029 | F>L | No | EVA | |
| rs3389238878 | 2031 | A>V | No | EVA |
No associated diseases with Q6GYP7
1 regional properties for Q6GYP7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Calcipressin-2, RNA recognition motif | 11 - 87 | IPR034919 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of small GTPase mediated signal transduction | Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZMV8 | RAP1GAP2 | Rap1 GTPase-activating protein 2 | Gallus gallus (Chicken) | PR |
| Q684P5 | RAP1GAP2 | Rap1 GTPase-activating protein 2 | Homo sapiens (Human) | PR |
| Q6GYQ0 | RALGAPA1 | Ral GTPase-activating protein subunit alpha-1 | Homo sapiens (Human) | PR |
| P49815 | TSC2 | Tuberin | Homo sapiens (Human) | PR |
| Q5SVL6 | Rap1gap2 | Rap1 GTPase-activating protein 2 | Mus musculus (Mouse) | PR |
| Q61037 | Tsc2 | Tuberin | Mus musculus (Mouse) | PR |
| P86409 | RALGAPA1 | Ral GTPase-activating protein subunit alpha-1 | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFSKKPHGDV | KKSTQKVLDT | KKDALTRLKH | LRIVIENAES | IDLKQFFDQH | FSHIYYVFFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NFVTIEASLK | QKGHKSQREE | LDAILFIFEK | ILQLLPERIH | QRWQFHSIGL | ILKKLLHTGN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLKIRREGVR | LFLLWLQALQ | DNCSKEQLWM | FSCLIPGFSA | PQSEYGPRTL | DNLINPPLSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QETQVTIEEV | TPLVPPQSGD | KGQEDLTSYF | LEALLKYIVI | QVKSLEWKNK | ENQERGFSFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSHFKKFYLP | YIFPNICKEN | SLYHPVLDIP | QIRPKPHYVM | IKKDAETNET | IYCTKEPFIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARVIVIRWLV | SFWLEPKPHS | GPNIPGMEGE | VLPKNIQRAA | ASLVSREESK | NDTVDKVDKS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEPEQSHSNT | STLTEREPSS | SSLCSIDEEH | LTDIEIVRRV | FSSKRSNVNF | VTEIFRQAFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPICEAAAMR | KVVKVYQEWI | QQEEKPLFMQ | EPEDTAITCS | DIPCSETVAD | HDSAIEDGEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REEENGTSTS | EHVRNSSWTK | NGSYQEAFHV | CEEATEQNIQ | AGTQAVLQVF | IINSSNIFLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EPANEIKNLL | DEHTDMCKRI | LNIYRYMVVQ | VSMDKKTWEQ | MLLVLLRVTE | SVLKMSSQAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQFQGKKSMT | LAGRLAGPLF | QTLIVAWIKA | NLNVYISREL | WDDLLSVLSS | LTYWEELATE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WSLTMETLTK | VLARNLYSLD | LSDLPLDKLS | EQKQKKHKGK | GVGHEFQKVS | VDKSFSRGWS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RDQPGQAPMR | QRSATTTGSP | GTEKARSIVR | QKTVDIDDAQ | ILPRSTRVRH | FSQSEDTGNE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VFGALHEEQP | LPRSSSTSDI | LEPFTVERAK | VNKEDTSPKL | PPLNSETGGN | SANVPDLMDE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FIAERLRSGN | ASTMTRRGSS | PGSLEIPKDL | PDILNKQNQM | RPVDDPGVPS | EWTSPASAGS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SDLMSSDSHS | DSFSAFQCEG | RKFDNFGFGT | DIGIPSSADV | DLGSGHHQST | EEQEVASLTT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LHLDSETSSL | NQQAFSAEVA | TVTGSESASP | VHSALGSRSQ | TPSPSTLSRA | HIEQKDLQLD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EKLHHSVLQT | PDDLEISEFP | SECCSVMAGG | TLTGWHADVA | TVMWRRMLGI | LGDVNAIMDP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EIHAQVFDYL | CELWQNLAKI | RDNLGISADN | LTSPSPPVLI | PPLRILTPWL | FKATMLTDKY |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KQGKLHAYKL | ICNTMKRRQD | VSPNRDFLTH | FYNIMHCGLL | HIDQDIVNTI | IKHCSPQFFS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LGLPGATMLI | MDFIIAAGRV | ASSAFLNAPR | VEAQVLLGSL | VCFPNLYCEL | PALHPNIPDI |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| AVSQFTDVKE | LIIKTVLSSA | RDEPSGPARC | VALCSLGIWI | CEELVHESHH | PQIKEALNVI |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| CVSLKFTNKT | VAHVACNMLH | MLVHYVPRLQ | IHQPQSPLKI | IQILIATITH | LLPSTEASSY |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| EMDKRLVVSL | LLCLLDWIMA | LPLKTLLQPV | HATGAENDKT | EKSVLNCIYK | VLHGCVYGAQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SFSNPKYFPI | SLSDLASVDY | DPFMHLESLK | EPEPLHSPDS | ERSSKLQPVT | EVKTQMQQGL |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| ISIAARTVIT | HLVNHLGHYP | MSGGPAMLTS | QVCENHDNHY | SESTELSPEL | FESPNIQFFV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LNNTTLVSCI | QIRSEESMPG | GGLAAGLVSA | NSNVRIIVRD | LSGKYSWDSA | ILYGPPIVSG |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LPEPTSFILS | MSDQEKPEEP | PTSNECLEDI | AVKDGLSLQL | RRFRETVPTW | STIREEEDVL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| DELLQYLGTT | SPECLQRTGI | SLNVPAPQPL | CISEKQENDV | INAILKQYTE | EKEFVEKHFN |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| DLNMKASEQD | EPTPQKPQSA | FYYCRLLLSI | LGMNSWDKRR | SFHLLKKNEK | LLRELRNLDS |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| RQCRETHKIA | VFYVAEGQED | KYSILTNIGG | SQAYEDFVAG | LGWEVNLTNH | CGFMGGLQKN |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| RSTGLTTPYF | ATSTVEVIFH | VSTRMPSDSD | DSLTKKLRHL | GNDEVHIVWS | EHTRDYRRGI |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| IPTEFGDVLI | VIYPMKNHMF | SIQIMKKPEV | PFFGPLFDGA | IVNGKVLPIM | VRSTAINASR |
| 1990 | 2000 | 2010 | 2020 | 2030 | |
| ALKSLIPLYQ | NFYEERARYL | QTIVQHHLEP | TTFEDFAAQV | FSPAPYHHFP | ADADH |