Q5ZMV8
Gene name |
RAP1GAP2 (GARNL4, RCJMB04_1a20) |
Protein name |
Rap1 GTPase-activating protein 2 |
Names |
Rap1GAP2, GTPase-activating Rap/Ran-GAP domain-like protein 4 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:427841 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZMV8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZMV8-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZMV8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZMV8 | |||||
No associated diseases with Q5ZMV8
1 regional properties for Q5ZMV8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rap/Ran-GAP domain | 247 - 463 | IPR000331 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| regulation of small GTPase mediated signal transduction | Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6GYQ0 | RALGAPA1 | Ral GTPase-activating protein subunit alpha-1 | Homo sapiens (Human) | PR |
| Q684P5 | RAP1GAP2 | Rap1 GTPase-activating protein 2 | Homo sapiens (Human) | PR |
| Q6GYP7 | Ralgapa1 | Ral GTPase-activating protein subunit alpha-1 | Mus musculus (Mouse) | PR |
| Q5SVL6 | Rap1gap2 | Rap1 GTPase-activating protein 2 | Mus musculus (Mouse) | PR |
| P86409 | RALGAPA1 | Ral GTPase-activating protein subunit alpha-1 | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFQRKRSVSF | GGYGWIDKTM | LASLKMKKQE | LLSSADVTLP | ERPLSPPLTA | PPTMKSAEFF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMLEKMQAPK | LEDQKAGSQK | HKEDYIPYPS | IDEILEKGSP | YPLVILPQFG | GYWIEDPENL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTPTSSDSSV | CEEEEENFSP | SPYGYKLECK | GEARAYRKHF | LGKDHLNFYC | TASSLGNLIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIKCEEVDGT | EYLRIILRSK | VKTLHERIPL | AGFSKLPSIP | QIAKAFCDDA | SGLKFNPVLY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKASQMIVAY | DEHEVNNTFK | FGVIYQKFRQ | TQEEELFGNN | EESAAFRNFL | NLLGDTITLQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DFKGFRGGLD | VSHGQTGVES | VYTVFRDREI | MFHVSTKLPF | TEGDTQQLQR | KRHIGNDIVA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IIFQEENTPF | VPDMIASNFL | HAYIVVQVEN | PDADTTSYKV | SVTAREDVPS | FGPPLPSPPV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FQKSPEFREF | LLTKLINAEN | ACCKSDKFAK | LEDRTRAALL | DNLHDELHGH | TQTMLGLGPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EDKLENGGHG | GFLESFKRAI | RVRSHSMETM | VGSQRKQHGG | GIPGSLSGGI | AHNSGEVTKT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TFSPPVSAAT | AKNQSRSPIK | RRSGLFPRLH | TGLESQVDSR | ARCDSISGPQ | KTPDVGHSSQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EMKSETSSNP | SSPEICPNKD | RPFVKLKENG | RSNISRSSSS | TSSFSSTAGE | SETLEEYDSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GSQPSTASPF | KQDVFIYSAS | PGSDSPSVGA | AATPVIMSRS | PTDIKNRNSP | RSNLKFRFDK |
| LSHGSSSTSH |