AiPD: Autoinhibited Protein Database

Gene name	Rap1gap2 (Garnl4, Kiaa1039, Rap1ga2)
Protein name	Rap1 GTPase-activating protein 2
Names	Rap1GAP2, GTPase-activating Rap/Ran-GAP domain-like protein 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:380711
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-63 (Predicted disordered autoinhibitory region) PR

1-63 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5SVL6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs258407951	3	A>V	No	EVA
rs3389142827	12	L>Q	No	EVA
rs3389177725	117	E>D	No	EVA
rs3389186264	145	K>E	No	EVA
rs211750142	172	M>I	No	EVA
rs3389174644	186	V>E	No	EVA
rs3389192909	227	Q>H	No	EVA
rs3389166014	272	L>*	No	EVA
rs3389179371	273	D>E	No	EVA
rs3389165943	318	T>I	No	EVA
rs3389186255	339	D>Y	No	EVA
rs29471703	372	N>S	No	EVA
rs3389182641	389	D>G	No	EVA
rs3389115078	510	G>R	No	EVA
rs3389186254	518	E>*	No	EVA
rs3389189228	531	A>V	No	EVA
rs3389178824	624	S>R	No	EVA
rs3389149329	627	S>N	No	EVA
rs3389186332	703	L>H	No	EVA
rs47134588	710	A>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Exonuclease, RNase T/DNA polymerase III	242 - 403	IPR013520
domain	RNA exonuclease 4, DEDDh 3'-5' exonuclease domain	244 - 394	IPR037431

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of cell size	Any process that modulates the size of a cell.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZMV8	RAP1GAP2	Rap1 GTPase-activating protein 2	Gallus gallus (Chicken)	PR
Q6GYQ0	RALGAPA1	Ral GTPase-activating protein subunit alpha-1	Homo sapiens (Human)	PR
Q684P5	RAP1GAP2	Rap1 GTPase-activating protein 2	Homo sapiens (Human)	PR
Q6GYP7	Ralgapa1	Ral GTPase-activating protein subunit alpha-1	Mus musculus (Mouse)	PR
P86409	RALGAPA1	Ral GTPase-activating protein subunit alpha-1	Sus scrofa (Pig)	PR