P86409

PR
Gene name
RALGAPA1
Protein name
Ral GTPase-activating protein subunit alpha-1
Names
GAP-related-interacting partner to E12, GRIPE, GTPase-activating Rap/Ran-GAP domain-like 1, Tuberin-like protein 1, p240
Species
Sus scrofa (Pig)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P86409

Entry ID Method Resolution Chain Position Source
AF-P86409-F1 Predicted AlphaFoldDB

No variants for P86409

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P86409

No associated diseases with P86409

No regional properties for P86409

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P86409

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Translocated to the nucleus, when associated with TCF3/E12
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

1 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZMV8 RAP1GAP2 Rap1 GTPase-activating protein 2 Gallus gallus (Chicken) PR
Q684P5 RAP1GAP2 Rap1 GTPase-activating protein 2 Homo sapiens (Human) PR
Q6GYQ0 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 Homo sapiens (Human) PR
Q5SVL6 Rap1gap2 Rap1 GTPase-activating protein 2 Mus musculus (Mouse) PR
Q6GYP7 Ralgapa1 Ral GTPase-activating protein subunit alpha-1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
70 80 90 100 110 120
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
130 140 150 160 170 180
SLKIRREGVR LFLLWLQALQ NNCSREQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLNL
190 200 210 220 230 240
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL
250 260 270 280 290 300
FSHFKKYYLP YIFPNICKEN SLYHPVLDIP QMRPKPHYVM IKKDAETNEA IYCTKEPFIK
310 320 330
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE VLPKNIQ