Q6DBM8
PR
Gene name |
MTPB (MTP4, At2g29410, F16P2.21) |
Protein name |
Metal tolerance protein B |
Names |
AtMTP4, AtMTPb |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G29410 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DBM8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DBM8-F1 | Predicted | AlphaFoldDB |
64 variants for Q6DBM8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05623952 | 11 | P>L | No | 1000Genomes | |
| tmp_2_12616859_T_G | 17 | M>R | No | 1000Genomes | |
| ENSVATH05623953 | 27 | E>D | No | 1000Genomes | |
| tmp_2_12616938_T_A | 43 | H>Q | No | 1000Genomes | |
| tmp_2_12616939_T_A | 44 | C>S | No | 1000Genomes | |
| tmp_2_12616940_G_A | 44 | C>Y | No | 1000Genomes | |
| tmp_2_12616960_C_T | 51 | R>C | No | 1000Genomes | |
| ENSVATH01923523 | 61 | L>F | No | 1000Genomes | |
| ENSVATH01923524 | 63 | F>L | No | 1000Genomes | |
| tmp_2_12616999_C_G | 64 | L>V | No | 1000Genomes | |
| tmp_2_12617011_G_A | 68 | V>I | No | 1000Genomes | |
| ENSVATH05623954 | 77 | F>L | No | 1000Genomes | |
| ENSVATH00253631 | 92 | L>F | No | 1000Genomes | |
| ENSVATH05623956 | 104 | A>T | No | 1000Genomes | |
| ENSVATH14569155 | 109 | S>N | No | 1000Genomes | |
| tmp_2_12617153_G_A | 115 | R>Q | No | 1000Genomes | |
| tmp_2_12617167_T_A | 120 | F>I | No | 1000Genomes | |
| tmp_2_12617189_C_T | 127 | A>V | No | 1000Genomes | |
| ENSVATH05623958 | 132 | V>I | No | 1000Genomes | |
| ENSVATH14569156 | 137 | L>F | No | 1000Genomes | |
| ENSVATH13467467 | 151 | L>R | No | 1000Genomes | |
| ENSVATH14569157 | 154 | S>R | No | 1000Genomes | |
| ENSVATH05623960 | 156 | E>K | No | 1000Genomes | |
| ENSVATH05623961 | 163 | F>I | No | 1000Genomes | |
| ENSVATH05623961 | 163 | F>V | No | 1000Genomes | |
| ENSVATH14569158 | 169 | G>E | No | 1000Genomes | |
| tmp_2_12617322_C_A | 171 | F>L | No | 1000Genomes | |
| tmp_2_12617321_T_C | 171 | F>S | No | 1000Genomes | |
| tmp_2_12617353_C_T | 182 | H>Y | No | 1000Genomes | |
| ENSVATH13467468 | 189 | H>P | No | 1000Genomes | |
| tmp_2_12617384_A_G | 192 | H>R | No | 1000Genomes | |
| tmp_2_12617398_A_G | 197 | N>D | No | 1000Genomes | |
| ENSVATH05623963 | 202 | H>R | No | 1000Genomes | |
| ENSVATH05623962 | 202 | H>Y | No | 1000Genomes | |
| ENSVATH01923526 | 204 | H>N | No | 1000Genomes | |
| ENSVATH01923526 | 204 | H>Y | No | 1000Genomes | |
| ENSVATH13467471 | 209 | V>M | No | 1000Genomes | |
| ENSVATH05623965 | 211 | A>E | No | 1000Genomes | |
| ENSVATH05623964 | 211 | A>T | No | 1000Genomes | |
| tmp_2_12617452_G_A | 215 | E>K | No | 1000Genomes | |
| tmp_2_12617477_G_A | 223 | G>D | No | 1000Genomes | |
| tmp_2_12617567_T_C | 253 | M>T | No | 1000Genomes | |
| tmp_2_12617609_T_C | 267 | L>S | No | 1000Genomes | |
| ENSVATH05623970 | 274 | L>F | No | 1000Genomes | |
| ENSVATH05623971 | 277 | S>F | No | 1000Genomes | |
| tmp_2_12617647_G_A | 280 | A>T | No | 1000Genomes | |
| ENSVATH14569159 | 281 | L>V | No | 1000Genomes | |
| ENSVATH00253636 | 287 | I>M | No | 1000Genomes | |
| ENSVATH01923530 | 296 | M>R | No | 1000Genomes | |
| tmp_2_12617701_C_T | 298 | R>C | No | 1000Genomes | |
| ENSVATH13467473 | 299 | V>L | No | 1000Genomes | |
| ENSVATH00253637 | 307 | K>Q | No | 1000Genomes | |
| ENSVATH00253638 | 308 | L>F | No | 1000Genomes | |
| tmp_2_12617734_G_C | 309 | E>Q | No | 1000Genomes | |
| tmp_2_12617741_G_A | 311 | G>E | No | 1000Genomes | |
| tmp_2_12617779_C_T | 324 | L>F | No | 1000Genomes | |
| ENSVATH13467474 | 326 | V>I | No | 1000Genomes | |
| ENSVATH05623976 | 328 | E>G | No | 1000Genomes | |
| ENSVATH05623977 | 329 | I>M | No | 1000Genomes | |
| ENSVATH05623978 | 342 | P>S | No | 1000Genomes | |
| ENSVATH00253639 | 345 | G>E | No | 1000Genomes | |
| tmp_2_12617883_C_A | 358 | F>L | No | 1000Genomes | |
| ENSVATH00253640 | 368 | A>V | No | 1000Genomes | |
| tmp_2_12617920_C_G | 371 | Q>E | No | 1000Genomes |
No associated diseases with Q6DBM8
No regional properties for Q6DBM8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6DBM8 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| zinc ion transmembrane transporter activity | Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| zinc ion transmembrane transport | A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P97441 | Slc30a3 | Zinc transporter 3 | Mus musculus (Mouse) | PR |
| Q2HJ10 | Slc30a2 | Zinc transporter 2 | Mus musculus (Mouse) | PR |
| P0CE46 | Slc30a8 | Zinc transporter 8 | Rattus norvegicus (Rat) | PR |
| Q9MAP1 | At1g33020 | Putative F-box protein At1g33020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M271 | MTPA1 | Metal tolerance protein A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELEQICILK | PDDEEEMESP | SPSKTEENLG | VVPLSCAFTR | QEHCVSETKE | REESTRRLSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIFLYLIVMS | VQIVGGFKAN | SLAVMTDAAH | LLSDVAGLCV | SLLAIKVSSW | EANPRNSFGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KRLEVLAAFL | SVQLIWLVSG | VIIHEAIQRL | LSRSREVNGE | IMFGISAFGF | FMNLVMVLWL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GHNHSHHHHD | HHHHHHNHKH | QHQHHHKEVV | AEEEEEEMNP | LKGEKSSSKE | MNINIQGAYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HAMADMIQSL | GVMIGGGIIW | VKPKWVLVDL | ICTLVFSAFA | LAATLPILKN | IFGILMERVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RDMDIEKLER | GLKRIDGVKI | VYDLHVWEIT | VGRIVLSCHI | LPEPGASPKE | IITGVRNFCR |
| 370 | |||||
| KSYGIYHATV | QVESE |