P97441
PR
Gene name |
Slc30a3 |
Protein name |
Zinc transporter 3 |
Names |
ZnT-3, Solute carrier family 30 member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22784 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97441
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97441-F1 | Predicted | AlphaFoldDB |
3 variants for P97441
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs263031369 | 117 | L>M | No | EVA | |
| rs3388745098 | 206 | S>I | No | EVA | |
| rs3388745158 | 254 | I>N | No | EVA |
No associated diseases with P97441
No regional properties for P97441
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P97441 | |||
Functions
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| hippocampal mossy fiber | Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. |
| hippocampal mossy fiber to CA3 synapse | One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. |
| integral component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| zinc ion transmembrane transporter activity | Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| detoxification of zinc ion | Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion. |
| positive regulation of transport | Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of sequestering of zinc ion | Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. |
| response to zinc ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. |
| sequestering of zinc ion | The process of binding or confining zinc ions such that they are separated from other components of a biological system. |
| zinc ion import into synaptic vesicle | The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle. |
| zinc ion transmembrane transport | A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| zinc ion transport | The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2HJ10 | Slc30a2 | Zinc transporter 2 | Mus musculus (Mouse) | PR |
| P0CE46 | Slc30a8 | Zinc transporter 8 | Rattus norvegicus (Rat) | PR |
| Q9MAP1 | At1g33020 | Putative F-box protein At1g33020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DBM8 | MTPB | Metal tolerance protein B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M271 | MTPA1 | Metal tolerance protein A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPSLATGGS | ETTRLVSARD | RSSAGGGLRL | KSLFTEPSEP | LPEEPKLEGM | AFHHCHKDPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQSGLSPERV | QARRQLYAAC | AVCFIFMAGE | VVGGYLAHSL | AIMTDAAHLL | ADIGSMLASL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FSLWLSTRPA | TRTMTFGWHR | SETLGALASV | VSLWIVTGIL | LYLAFLRLLH | SDYHIEAGAM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLTASIAVCA | NLLMAFVLHQ | TGAPHSHGST | GAEYAPLEEG | HGYPMSLGNT | SVRAAFVHVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDLLQSFGVL | AASILIYFKP | QYKVADPIST | FLFSICALGS | TAPTLRDVLL | VLMEGAPRSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EFEPVRDTLL | SVPGVRATHD | LHLWALTLTY | HVASAHLAID | STADPEAVLA | EASSRLYSRF |
| 370 | 380 | ||||
| GFSSCTLQVE | QYQPEMAQCL | RCQEPSQA |