P0CE46

PR
Gene name
Slc30a8 (Znt8)
Protein name
Zinc transporter 8
Names
ZnT-8, Solute carrier family 30 member 8
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:299903
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CE46

Entry ID Method Resolution Chain Position Source
AF-P0CE46-F1 Predicted AlphaFoldDB

1 variants for P0CE46

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3321194482 294 D>N No EVA

No associated diseases with P0CE46

No regional properties for P0CE46

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P0CE46

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Associated with insulin and glucagon secretory granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
transport vesicle membrane The lipid bilayer surrounding a transport vesicle.

2 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.
zinc ion transmembrane transporter activity Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

12 GO annotations of biological process

Name Definition
cellular zinc ion homeostasis Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
regulation of sequestering of zinc ion Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
response to interferon-gamma Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
sequestering of zinc ion The process of binding or confining zinc ions such that they are separated from other components of a biological system.
zinc ion transmembrane transport A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
zinc ion transport The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P97441 Slc30a3 Zinc transporter 3 Mus musculus (Mouse) PR
Q2HJ10 Slc30a2 Zinc transporter 2 Mus musculus (Mouse) PR
Q9MAP1 At1g33020 Putative F-box protein At1g33020 Arabidopsis thaliana (Mouse-ear cress) PR
Q6DBM8 MTPB Metal tolerance protein B Arabidopsis thaliana (Mouse-ear cress) PR
Q9M271 MTPA1 Metal tolerance protein A1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEFLERTYLV NDQATKMYAF TSDRERGQKP VNKDQCPGDG PERPEAGAIY HCHNSFKATG
70 80 90 100 110 120
NRSSKQVHAK WRLCAASAIC FFFMVAEVVG GHVAGSLAVL TDAAHLLIDL TSFLLSLFSL
130 140 150 160 170 180
WLSSRPPSKR LTFGWYRAEI LGALLSVLCI WVVTGVLVYL ACERLLYPDY QIQAGIMITV
190 200 210 220 230 240
SGCAVAANIV LTLILHQRHL GHNHKDAQAN ASVRAAFVHA LGDVFQSTSV LISALIIYFK
250 260 270 280 290 300
PDYKMADPVC TFISSVLALA STVMILKDFS ILLMEGVPKG LSYNSVKELL LTVDGVISVH
310 320 330 340 350 360
NLHIWSLTVN QVILSVHVAT AASQDSQSVR TGIACALSSS FDLHSLTIQI ESAADQDPSC
LLCEDPQD