Q66GQ3
Gene name |
PDIL1-6 (PDI4, PDIL3-2, At3g16110, MSL1.15) |
Protein name |
Protein disulfide isomerase-like 1-6 |
Names |
AtPDIL1-6, Protein disulfide isomerase 4, AtPDI4, Protein disulfide isomerase-like 3-2, AtPDIL3-2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G16110 |
EC number |
5.3.4.1: Transposing S-S bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q66GQ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q66GQ3-F1 | Predicted | AlphaFoldDB |
37 variants for Q66GQ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13928324 | 2 | L>S | No | 1000Genomes | |
| ENSVATH05841335 | 7 | P>S | No | 1000Genomes | |
| ENSVATH05841334 | 8 | N>I | No | 1000Genomes | |
| ENSVATH02150373 | 9 | S>F | No | 1000Genomes | |
| ENSVATH00326171 | 32 | D>E | No | 1000Genomes | |
| tmp_3_5463425_T_C | 81 | N>S | No | 1000Genomes | |
| tmp_3_5463375_A_T | 98 | L>I | No | 1000Genomes | |
| ENSVATH05841332 | 109 | E>D | No | 1000Genomes | |
| tmp_3_5463308_T_A | 120 | D>V | No | 1000Genomes | |
| ENSVATH02150372 | 124 | I>V | No | 1000Genomes | |
| ENSVATH10710213 | 160 | T>I | No | 1000Genomes | |
| ENSVATH10710214 | 160 | T>S | No | 1000Genomes | |
| ENSVATH00326170 | 161 | S>F | No | 1000Genomes | |
| tmp_3_5463181_C_G | 162 | Q>H | No | 1000Genomes | |
| tmp_3_5463161_G_A | 169 | S>F | No | 1000Genomes | |
| tmp_3_5463036_C_A | 182 | G>C | No | 1000Genomes | |
| ENSVATH05841325 | 214 | D>Y | No | 1000Genomes | |
| ENSVATH02150371 | 240 | D>N | No | 1000Genomes | |
| ENSVATH05841323 | 250 | K>I | No | 1000Genomes | |
| tmp_3_5462469_C_T | 271 | G>R | No | 1000Genomes | |
| ENSVATH05841320 | 290 | V>I | No | 1000Genomes | |
| ENSVATH10710205 | 314 | S>L | No | 1000Genomes | |
| tmp_3_5462211_T_G | 318 | D>A | No | 1000Genomes | |
| tmp_3_5462196_G_A | 323 | A>V | No | 1000Genomes | |
| tmp_3_5461984_T_G | 363 | K>T | No | 1000Genomes | |
| ENSVATH10710152 | 382 | S>L | No | 1000Genomes | |
| ENSVATH00326165 | 395 | G>R | No | 1000Genomes | |
| tmp_3_5461695_G_A | 402 | S>L | No | 1000Genomes | |
| tmp_3_5461696_A_T | 402 | S>T | No | 1000Genomes | |
| tmp_3_5461569_C_T | 418 | V>I | No | 1000Genomes | |
| tmp_3_5461557_C_T | 422 | V>I | No | 1000Genomes | |
| ENSVATH10710151 | 471 | F>S | No | 1000Genomes | |
| tmp_3_5461285_G_A | 482 | P>L | No | 1000Genomes | |
| tmp_3_5461189_T_A | 487 | D>V | No | 1000Genomes | |
| ENSVATH05841307 | 501 | E>G | No | 1000Genomes | |
| tmp_3_5461038_T_G | 508 | T>P | No | 1000Genomes | |
| tmp_3_5461010_A_C | 517 | V>G | No | 1000Genomes |
No associated diseases with Q66GQ3
No regional properties for Q66GQ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q66GQ3 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.4.1 | Transposing S-S bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q29RV1 | PDIA4 | Protein disulfide-isomerase A4 | Bos taurus (Bovine) | PR |
| Q8N807 | PDILT | Protein disulfide-isomerase-like protein of the testis | Homo sapiens (Human) | PR |
| Q13087 | PDIA2 | Protein disulfide-isomerase A2 | Homo sapiens (Human) | PR |
| Q5WA72 | PDIL1-5 | Protein disulfide isomerase-like 1-5 | Oryza sativa subsp japonica (Rice) | PR |
| Q17770 | pdi-2 | Protein disulfide-isomerase 2 | Caenorhabditis elegans | PR |
| A3KPF5 | PDIL1-5 | Protein disulfide isomerase-like 1-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTKPKPNSK | FSILFTFLLL | LSFLIFVARS | SDVAVEAGSE | EELDDLEQLL | AVDEQLQEER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PEQQSEAETV | SKAQRIVVEL | NGDNTKRLID | GNEYVMVLGY | APWCARSAEL | MPRFAEAATD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKEIGSSVLM | AKIDGERYSK | VASQLEIKGF | PTLLLFVNGT | SQSYTGGFSS | EEIVIWVQKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGASTIKLDT | VDEASGFLKK | HHTFILGLFE | KSEDSSGHDE | FVKAASLDNE | IQFVETSSID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAKLLFPNLK | TNNVFVGLVK | TEAEKYTSYD | GPCQAEKIVE | FLNSNKFPLV | TKLTESNTVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VYSSPVKLQV | MVFSKTDDFE | SLAQPLEDIA | RKFKSKLMLI | YIDISNENLA | MPFLTLFGIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DAKKTVVAAF | DNNLNSKYLL | ESDPSPSNIE | EFCFGLAHGT | VSAYYKSQPI | PDNQNASVVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVGRTFDEVV | LRSSENVLLE | VHTPWCINCE | ALSKQVEKLS | QHFKGFENLV | FARIDASANE |
| 490 | 500 | 510 | 520 | 530 | |
| HPKLTVDDYP | TILLYKTGEK | ENPLKLSTKS | SAKDMAVLIN | KELKWKDQSG | KDEL |