Q29RV1

PR
Gene name
PDIA4
Protein name
Protein disulfide-isomerase A4
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:415110
EC number
5.3.4.1: Transposing S-S bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29RV1

Entry ID Method Resolution Chain Position Source
AF-Q29RV1-F1 Predicted AlphaFoldDB

No variants for Q29RV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q29RV1

No associated diseases with Q29RV1

10 regional properties for Q29RV1

Type Name Position InterPro Accession
domain Protein disulfide-isomerase, thioredoxin-like domain 66 - 165 IPR005788-1
domain Protein disulfide-isomerase, thioredoxin-like domain 181 - 281 IPR005788-2
domain Protein disulfide-isomerase, thioredoxin-like domain 529 - 632 IPR005788-3
domain Thioredoxin domain 20 - 168 IPR013766-1
domain Thioredoxin domain 170 - 300 IPR013766-2
domain Thioredoxin domain 503 - 634 IPR013766-3
conserved_site Thioredoxin, conserved site 82 - 100 IPR017937-1
conserved_site Thioredoxin, conserved site 197 - 215 IPR017937-2
conserved_site Thioredoxin, conserved site 545 - 563 IPR017937-3
domain Protein disulfide-isomerase A4, TRX-like domain b 285 - 391 IPR041866

Functions

Description
EC Number 5.3.4.1 Transposing S-S bonds
Subcellular Localization
  • Endoplasmic reticulum lumen
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

1 GO annotations of molecular function

Name Definition
protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13087 PDIA2 Protein disulfide-isomerase A2 Homo sapiens (Human) PR
Q5WA72 PDIL1-5 Protein disulfide isomerase-like 1-5 Oryza sativa subsp japonica (Rice) PR
Q17770 pdi-2 Protein disulfide-isomerase 2 Caenorhabditis elegans PR
A3KPF5 PDIL1-5 Protein disulfide isomerase-like 1-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q66GQ3 PDIL1-6 Protein disulfide isomerase-like 1-6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRPRKAWMLV LLLALVQLLA VASAGAPDED STDKEDAIEE DEEEDEDDDD DDDDLEVKEE
70 80 90 100 110 120
NGVLILNDAN FDNFVADKDT VLLEFYAPWC GHCKQFAPEY EKIAATLKEN DPPIPVAKID
130 140 150 160 170 180
ATSESALASR FDVSGYPTIK ILKKGQEVDY EGSRTQEEIV AKVKEVSQPN WTPPPEVTLV
190 200 210 220 230 240
LTKDNFDEVV NDADIILVEF YAPWCGHCKK LAPEYEKAAK ELSKSSPPIP LAKVDAIAET
250 260 270 280 290 300
DLAKRFDVSS YPTLKIFRKG KAFSYNGPRE KYGIVDYMME QSGPPSKQIL ALKQVQEFLK
310 320 330 340 350 360
DGDDVIIIGV FKSESDPAYQ LYQDAANSLR EDYKFHHTFS TEIAKFLKVS LGKLVVMQPE
370 380 390 400 410 420
KFQSKYEPKS YVMDIKDSTE AAAITEHVVK HTLPLVGHRK AADAKRYTRR PLVVVYYSVD
430 440 450 460 470 480
FSFDYRAATQ FWRNKVLEVA KDFPEYTFAV ADEEDFATEL KDLGLSESGE EVNAAILDEG
490 500 510 520 530 540
GRRFAMEPDD FDADALRDFV TAFKKGKLKP VIKSQPVPKN NKGPVKVVVG KTFDSIVMDP
550 560 570 580 590 600
KKDVLIEFYA PWCGHCKQLE PVYTSLGKKY KGHKNLVIAK MDATANDVTS DRYKVEGFPT
610 620 630 640
IYFAPSGDKK KPIKFEDGNR DLEHLSKFIE EHATKLSRTK EEL