AiPD: Autoinhibited Protein Database

Q13087

Gene name	PDIA2 (PDIP)
Protein name	Protein disulfide-isomerase A2
Names	Pancreas-specific protein disulfide isomerase, PDIp
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64714
EC number	5.3.4.1: Transposing S-S bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-65 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q13087

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q13087-F1	Predicted				AlphaFoldDB

695 variants for Q13087

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001263409 rs373590123 CA394053693	128	R>H	Bicuspid aortic valve [ClinVar]	Yes	ClinGen ClinVar ESP TOPMed dbSNP gnomAD
rs375763771 CA7772764	3	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7772765 rs200211074	3	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772766 rs200211074	3	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394049227 rs1369867447	4	Q>H		No	ClinGen gnomAD
rs1231624291 CA394049245	5	L>P		No	ClinGen gnomAD
rs759297031 CA7772768	7	P>R		No	ClinGen ExAC gnomAD
CA276491596 rs764795732	8	V>I		No	ClinGen ExAC TOPMed gnomAD
rs764795732 CA7772769	8	V>L		No	ClinGen ExAC TOPMed gnomAD
rs927724382 CA276491613	14	L>F		No	ClinGen gnomAD
CA276491618 rs866883356	16	A>S		No	ClinGen Ensembl
rs938980328 CA276491621	16	A>V		No	ClinGen Ensembl
rs762917912 CA7772775	17	S>L		No	ClinGen ExAC TOPMed gnomAD
rs762917912 CA394049592	17	S>W		No	ClinGen ExAC TOPMed gnomAD
CA7772777 rs751357691	19	P>A		No	ClinGen ExAC gnomAD
CA7772778 rs757040076	19	P>L		No	ClinGen ExAC TOPMed gnomAD
rs751357691 CA394049656	19	P>S		No	ClinGen ExAC gnomAD
rs199610908 CA7772780	20	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1458651907 CA394049743	21	G>D		No	ClinGen TOPMed
CA7772781 rs755205619	22	Q>*		No	ClinGen ExAC gnomAD
CA276491648 rs762913132	23	E>K		No	ClinGen gnomAD
rs778893713 CA394049887	24	Q>*		No	ClinGen ExAC
rs778893713 CA7772782	24	Q>E		No	ClinGen ExAC
CA394049898 rs1393107730	24	Q>R		No	ClinGen TOPMed gnomAD
CA7772784 rs202221434	26	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed
COSM1579866 rs202221434 CA7772783	26	A>V	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed
rs771161420 CA7772788	27	R>K		No	ClinGen ExAC TOPMed gnomAD
rs745460507 CA7772790	28	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1567248767 CA394050149	29	P>L		No	ClinGen Ensembl
rs910032721 CA276491662	29	P>S		No	ClinGen TOPMed
CA7772792 rs769578461	30	S>*		No	ClinGen ExAC TOPMed gnomAD
rs769578461 CA7772791	30	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1224830898 CA394050219	31	E>D		No	ClinGen gnomAD
rs1289719460 CA394050237	32	E>G		No	ClinGen gnomAD
rs1215589103 CA394050266	33	P>L		No	ClinGen gnomAD
rs200720054 CA7772795	33	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1253905972 CA394050272	34	P>A		No	ClinGen gnomAD
CA7772796 rs376929316	34	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	35	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1230960382 CA394050353	36	E>G		No	ClinGen gnomAD
CA7772797 rs767154871	37	E>K		No	ClinGen ExAC gnomAD
rs1159091193 CA394050482	38	I>T		No	ClinGen TOPMed gnomAD
rs45455191 CA7772798 VAR_048087	39	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752750026 CA7772801	41	E>D		No	ClinGen ExAC TOPMed gnomAD
rs765500005 CA7772800	41	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1390455232 CA394050689	42	D>N		No	ClinGen gnomAD
CA276491698 rs917510924	43	G>R		No	ClinGen TOPMed
rs768170675 CA394050780	44	I>F		No	ClinGen Ensembl
CA276491701 rs768170675	44	I>V		No	ClinGen Ensembl
CA276491705 rs962094564	45	L>S		No	ClinGen gnomAD
CA7772803 rs777942192	46	V>M		No	ClinGen ExAC gnomAD
CA7772804 rs751962286	47	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1333287299 CA394050899	48	S>R		No	ClinGen gnomAD
CA394050952 rs1273873474	49	R>C		No	ClinGen gnomAD
CA7772805 rs757796245	49	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757796245 CA394050961	49	R>P		No	ClinGen ExAC TOPMed gnomAD
CA394050979 rs1173496190	50	H>Y		No	ClinGen TOPMed
CA394051021 rs1389951094	51	T>S		No	ClinGen Ensembl
CA7772807 rs746305346	52	L>R		No	ClinGen ExAC gnomAD
CA394051074 rs1390253242	53	G>D		No	ClinGen TOPMed
CA394051054 rs1474173477	53	G>S		No	ClinGen gnomAD
rs748977033 CA7772811	55	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7772813 rs773922251	56	L>P		No	ClinGen ExAC TOPMed gnomAD
rs200654902 CA7772817	57	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs199805826 CA7772816	57	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1567248858 CA394051201	59	H>R		No	ClinGen Ensembl
CA394051221 rs1294374909	61	A>T		No	ClinGen gnomAD
CA7772820 rs368323306	61	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA394051279 rs1567248879	66	F>V		No	ClinGen Ensembl
rs1316332169 CA394052630	67	Y>C		No	ClinGen TOPMed gnomAD
rs1408537527 CA394052644	68	A>D		No	ClinGen TOPMed
rs372266436 CA7772854	69	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA276492808 rs372266436	69	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567249329 CA394052672	70	W>*		No	ClinGen Ensembl
rs1329266665 CA394052680	70	W>*		No	ClinGen gnomAD
CA394052696 rs1212479825	71	C>Y		No	ClinGen gnomAD
CA394052730 rs1477973238	73	H>R		No	ClinGen gnomAD
CA394052724 rs1250795993	73	H>Y		No	ClinGen TOPMed gnomAD
CA394052748 rs1192198945	74	C>Y		No	ClinGen gnomAD
rs1003087839 CA276492814	77	L>M		No	ClinGen TOPMed
rs1417637061 CA394052798	78	A>D		No	ClinGen TOPMed gnomAD
CA394052797 rs1417637061	78	A>G		No	ClinGen TOPMed gnomAD
CA394052799 rs1417637061 COSM1377036	78	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA394052806 rs1161939680	79	P>L		No	ClinGen gnomAD
rs1035512919 CA276492822	80	E>K		No	ClinGen TOPMed gnomAD
CA7772859 rs757884006	81	Y>C		No	ClinGen ExAC gnomAD
CA276492823 rs763297114	81	Y>H		No	ClinGen TOPMed gnomAD
rs1228280751 CA394052850	82	S>G		No	ClinGen TOPMed
CA276492831 rs958809173	83	K>N		No	ClinGen TOPMed
rs1596940841 CA394052873	83	K>R		No	ClinGen Ensembl
rs1466415986 CA394052894	84	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	86	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394052931 rs199987128	87	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772863 rs199987128	87	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1232202844 CA394052967	89	A>T		No	ClinGen TOPMed gnomAD
rs768743092 CA7772865	89	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	90	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs558374938 CA7772868	91	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs558374938 CA7772869	91	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs754129630 CA7772872	92	S>L		No	ClinGen ExAC gnomAD
rs767047256 CA7772871	92	S>P		No	ClinGen ExAC gnomAD
CA7772874 rs765549988	93	M>T		No	ClinGen ExAC gnomAD
rs115506610 CA7772873	93	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs951592626 CA276492886	94	V>A		No	ClinGen TOPMed
rs752347005 CA7772875	94	V>M		No	ClinGen ExAC gnomAD
CA7772876 rs371790739	96	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs746588565 CA7772878	98	A>V		No	ClinGen ExAC gnomAD
CA394053138 rs1351097761	99	K>N		No	ClinGen TOPMed gnomAD
rs937133936 CA276492906	100	V>M		No	ClinGen Ensembl
CA394053166 rs1309797134	101	D>A		No	ClinGen TOPMed
CA276492907 rs1055378239	101	D>N		No	ClinGen Ensembl
rs1222510850 CA394053176	102	G>R		No	ClinGen TOPMed
CA7772880 rs781159293	103	P>H		No	ClinGen ExAC TOPMed gnomAD
rs916947925 CA276492910	103	P>S		No	ClinGen gnomAD
CA394053211 rs1037921792	104	A>E		No	ClinGen TOPMed gnomAD
rs202228688 CA7772881	104	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1037921792 CA276492920	104	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	105	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1454432383 CA394053219	105	Q>E		No	ClinGen TOPMed
CA7772883 rs199711437	106	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7772885 rs748331680	106	R>H		No	ClinGen ExAC gnomAD
CA394053255 rs1485510620	107	E>D		No	ClinGen TOPMed gnomAD
CA7772887 rs773408295	107	E>K		No	ClinGen ExAC gnomAD
rs771532613 CA7772889	111	E>*		No	ClinGen ExAC gnomAD
rs1379486227 CA394053277	111	E>A		No	ClinGen TOPMed
rs1478473384 CA394053325	113	G>A		No	ClinGen gnomAD
rs182349041 CA394053367	115	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs182349041 CA7772893	115	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394053370 rs182349041	115	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772895 rs187002943	116	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750328553 CA7772899	117	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA7772898 rs756805133	117	Y>D		No	ClinGen ExAC gnomAD
rs750328553 CA394053419	117	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA7772897 rs756805133	117	Y>H		No	ClinGen ExAC gnomAD
CA276492974 rs755831573	118	P>S		No	ClinGen gnomAD
CA7772900 rs756007429	119	T>A		No	ClinGen ExAC gnomAD
CA394053454 rs45614840	119	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772902 rs45614840	119	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_048088 rs45614840 CA7772901	119	T>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs747264012 CA7772906	123	F>S		No	ClinGen ExAC TOPMed
CA7772907 rs771084733	124	R>C		No	ClinGen ExAC TOPMed gnomAD
rs374722948 CA7772908	124	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374722948 CA394053590	124	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs770272113 CA7772910	125	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1031621023 CA276493055	126	G>R		No	ClinGen TOPMed
CA7772913 rs367938749	128	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367938749 CA394053684	128	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373590123 CA276493068	128	R>P		No	ClinGen ESP TOPMed gnomAD
COSM970406 CA7772914 rs200818617	129	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs201820740 CA7772916	130	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs774230086 CA7772918	131	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7772917 rs749965703	131	P>S		No	ClinGen ExAC gnomAD
rs1041992279 CA276493103	132	E>G		No	ClinGen gnomAD
CA7772921 rs754780227	132	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7772922 rs778870993	133	E>K		No	ClinGen ExAC TOPMed gnomAD
COSM970407 CA7772923 rs767849091	135	T>A	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7772925 rs781330118	135	T>I		No	ClinGen ExAC gnomAD
rs767849091 CA7772924	135	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1409795593 CA394053942	136	G>E		No	ClinGen gnomAD
rs532272495 CA7772926 CA7772927	136	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394053951 rs1355725772	137	P>S		No	ClinGen TOPMed
rs11863142 CA7772958	138	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771720140 CA7772957	138	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7772959 rs760396848	139	D>N		No	ClinGen ExAC gnomAD
CA7772962 rs776284985	140	A>P		No	ClinGen ExAC TOPMed gnomAD
rs776284985 CA7772961	140	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1325095825 CA394054018	142	G>A		No	ClinGen TOPMed
CA7772964 rs578059477	142	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs867457169 CA276493382	144	A>V		No	ClinGen TOPMed gnomAD
rs1378974329 CA394054060	145	E>A		No	ClinGen TOPMed
CA7772966 rs200919010	145	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA394054079 rs1473959162	146	W>*		No	ClinGen gnomAD
CA394054074 rs1255958422	146	W>R		No	ClinGen TOPMed gnomAD
CA7772967 rs750565788	147	L>V		No	ClinGen ExAC TOPMed
CA7772969 rs370453080	148	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs780045155 CA7772970	148	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs367684102 CA7772972	149	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753974693 CA7772971	149	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7772974 rs200585521	150	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772973 rs370270759	150	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778212401 CA7772977	151	V>G		No	ClinGen ExAC
rs772275346 CA7772976	151	V>M		No	ClinGen ExAC
rs1374142072 CA394054169	152	G>W		No	ClinGen gnomAD
CA7772980 rs376065186	153	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394054193 rs1326141115	153	P>L		No	ClinGen gnomAD
rs759166965 CA7772981	154	S>R		No	ClinGen ExAC gnomAD
CA394054220 rs1394092266	155	A>P		No	ClinGen gnomAD
CA7772982 rs769824488	155	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1279575451 CA394054233	156	M>I		No	ClinGen gnomAD
CA7772984 rs762974185	156	M>L		No	ClinGen ExAC gnomAD
CA7772986 rs560699869	157	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA7772985 rs369185635	157	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	158	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394054248 rs1190602550	159	E>G		No	ClinGen TOPMed gnomAD
rs45593734 CA394054259	160	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7772990 rs766634062	161	E>K		No	ClinGen ExAC TOPMed gnomAD
rs368640160 CA7772991	162	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1384365120 CA394054273	163	A>P		No	ClinGen gnomAD
rs1384365120 CA394054272	163	A>T		No	ClinGen gnomAD
rs201535947 CA7772994	164	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs201535947 CA7772995	164	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1435610988 CA394054292	165	Q>E		No	ClinGen gnomAD
rs199979141 CA7772997	166	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7772996 rs199979141	166	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs775081375 CA7773002	169	G>A		No	ClinGen ExAC gnomAD
CA7773001 rs201182745	169	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768709968 CA7773004	171	R>Q		No	ClinGen ExAC gnomAD
CA7773003 COSM3690984 rs200501001	171	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs374019509 CA7773005	172	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs767328855 CA7773008	174	V>G		No	ClinGen ExAC TOPMed gnomAD
CA7773007 rs761632618	174	V>M		No	ClinGen ExAC gnomAD
rs759766478 CA7773010	175	V>L		No	ClinGen ExAC gnomAD
CA394054427 rs1440859514	176	I>N		No	ClinGen Ensembl
rs758817588 CA7773013	179	F>L		No	ClinGen ExAC TOPMed
CA394054485 rs1173083838	180	Q>*		No	ClinGen TOPMed
CA394054498 rs751841084	180	Q>H		No	ClinGen ExAC gnomAD
rs200228977 CA7773014	180	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773042 rs754460211	181	D>H		No	ClinGen ExAC gnomAD
CA394054563 rs754460211	181	D>N		No	ClinGen ExAC gnomAD
CA276493713 rs778297395	182	L>M		No	ClinGen ExAC TOPMed gnomAD
CA394054576 rs778297395	182	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1413690564 CA394054585	183	Q>*		No	ClinGen gnomAD
CA394054597 rs1489141451	183	Q>H		No	ClinGen gnomAD
rs375612067 CA276493715 CA7773045	184	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs748011037 CA7773044	184	D>G		No	ClinGen ExAC gnomAD
rs769876785 CA394054623	185	E>D		No	ClinGen ExAC gnomAD
rs419949 CA7773047 VAR_048089	185	E>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs372580263 CA7773050	187	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs141542731 CA7773051	188	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276493768 rs745414531	191	L>S		No	ClinGen Ensembl
rs774579574 CA7773054	192	A>V		No	ClinGen ExAC gnomAD
CA7773058 rs750781857	194	A>V		No	ClinGen ExAC gnomAD
CA7773059 rs45619835	195	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394055715 rs543187098	196	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7773062 rs766673308	196	D>V		No	ClinGen ExAC gnomAD
CA7773064 rs146199896	197	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394055759 rs1437576279	199	D>H		No	ClinGen TOPMed
CA7773067 rs758307937	200	M>I		No	ClinGen ExAC gnomAD
rs182786959 CA7773066	200	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746980351 CA394055857	203	G>R		No	ClinGen ExAC gnomAD
CA7773069 rs746980351	203	G>S		No	ClinGen ExAC gnomAD
CA394055876 rs1347526797	204	L>F		No	ClinGen gnomAD
CA276494853 rs1038326301	206	D>V		No	ClinGen TOPMed
rs372281111 CA7773071	206	D>Y		No	ClinGen ESP ExAC gnomAD
rs148442250 CA7773074	207	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773072 rs554427910	207	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7773075 rs762036991	208	P>A		No	ClinGen ExAC gnomAD
CA7773077 rs529793670	208	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762036991 CA7773076	208	P>S		No	ClinGen ExAC gnomAD
rs369120877 CA7773080	209	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs376264450 CA7773079	209	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1053318654 CA394055973	210	L>F		No	ClinGen TOPMed
rs1053318654 CA276494874	210	L>V		No	ClinGen TOPMed
rs892882155 CA276494875	213	Q>*		No	ClinGen gnomAD
rs1244866071 CA394056052	213	Q>P		No	ClinGen TOPMed gnomAD
CA7773083 rs764918166	217	T>A		No	ClinGen ExAC TOPMed gnomAD
CA394056109 rs764918166	217	T>P		No	ClinGen ExAC TOPMed gnomAD
CA7773085 rs372943195	218	K>M		No	ClinGen ESP ExAC gnomAD
rs372943195 CA7773084	218	K>R		No	ClinGen ESP ExAC gnomAD
CA394056149 rs1176357189	219	D>N		No	ClinGen TOPMed
CA7773087 rs751457648	220	T>I		No	ClinGen ExAC gnomAD
CA7773089 rs376102312	221	V>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs868281531	221	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7773088 rs757148478	221	V>M		No	ClinGen ExAC gnomAD
rs1368890993 CA394056272	223	L>F		No	ClinGen gnomAD
CA7773092 rs45591741	225	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1331246481 CA394056365	226	K>*		No	ClinGen gnomAD
rs780004822 CA7773110	227	F>L		No	ClinGen ExAC gnomAD
rs1425090822 CA394056473	227	F>S		No	ClinGen TOPMed
rs748310598 CA7773111	228	D>H		No	ClinGen ExAC gnomAD
CA276494956 rs569780896	230	G>E		No	ClinGen 1000Genomes TOPMed gnomAD
rs1305020712 CA394056532	230	G>R		No	ClinGen gnomAD
rs569780896 CA394056547	230	G>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs201566545 CA276494964	231	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA7773116 rs201566545	231	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA7773114 rs747106019 COSM1377038	231	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs577114086 CA7773117	234	F>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1356578822 CA394056657	235	P>S		No	ClinGen TOPMed gnomAD
rs1356578822 CA394056653	235	P>T		No	ClinGen TOPMed gnomAD
CA394056678 rs770087656	236	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7773120 rs770087656	236	V>M		No	ClinGen ExAC TOPMed gnomAD
rs541312273 CA7773121	237	D>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394056704 rs367677538 CA394056702	237	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374948503 CA7773123	238	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773125 rs370007425	239	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773893698 CA7773124	239	E>G		No	ClinGen ExAC gnomAD
CA276494991 rs911653182	240	L>R		No	ClinGen TOPMed
CA394056752 rs1401987181	240	L>V		No	ClinGen TOPMed
CA394056818 rs1344215013	244	L>V		No	ClinGen gnomAD
CA394056840 rs1422449017	245	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7773130 rs756121843	245	G>R		No	ClinGen ExAC gnomAD
CA394056850 rs766270520	246	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7773131 rs766270520	246	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1237659912 CA394056860	246	D>V		No	ClinGen gnomAD
rs200837199 CA276495023	247	L>M		No	ClinGen ExAC gnomAD
rs747942356 CA7773136	248	S>*		No	ClinGen ExAC TOPMed gnomAD
rs747942356 CA7773135	248	S>L		No	ClinGen ExAC TOPMed gnomAD
CA7773138 rs372835448	249	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA394056914 rs372835448	249	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773140 rs377242875	249	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773139 rs377242875	249	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	250	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1295126998 CA394057003	253	T>I		No	ClinGen gnomAD
rs768269726 CA7773145	254	H>D		No	ClinGen ExAC gnomAD
CA7773146 rs773839873	254	H>R		No	ClinGen ExAC gnomAD
CA276495095 rs886348559	256	M>T		No	ClinGen TOPMed
rs761537026 CA7773147	257	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7773148 rs369322100	257	R>H	Variant assessed as Somatic; 9.295e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs761537026 CA394057074	257	R>S		No	ClinGen ExAC TOPMed gnomAD
CA394057084 rs1464156048	258	L>V		No	ClinGen gnomAD
TCGA novel	260	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7773150 rs376254895	260	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238754809 CA394057137	261	E>A		No	ClinGen Ensembl
CA7773153 rs759364401	262	F>C		No	ClinGen ExAC TOPMed gnomAD
rs759364401 CA276495118	262	F>S		No	ClinGen ExAC TOPMed gnomAD
CA7773155 rs751675270	263	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1596942728 CA394057187	263	N>S		No	ClinGen Ensembl
CA394057207 rs1173222834	264	S>N		No	ClinGen gnomAD
CA394057229 rs1388269706	265	Q>*		No	ClinGen gnomAD
rs1455850363 CA394057242 CA394057240	265	Q>H		No	ClinGen TOPMed gnomAD
rs1448351156 CA394057237	265	Q>R		No	ClinGen gnomAD
rs1366625634 CA394057337	266	T>A		No	ClinGen gnomAD
CA7773189 rs147960863	266	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7773193 rs773377330	268	A>D		No	ClinGen ExAC gnomAD
rs1426497113 CA394057364	268	A>P		No	ClinGen TOPMed gnomAD
rs1427611090 CA394057376	269	K>T		No	ClinGen TOPMed
CA394057385 rs1414200240	270	I>V		No	ClinGen TOPMed gnomAD
CA7773196 rs367835970	272	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs372165409 CA7773197	272	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1260902071 CA394057426	273	A>T		No	ClinGen TOPMed
rs753168115 CA7773199	274	R>G		No	ClinGen ExAC gnomAD
rs1340491207 CA394057440	274	R>K		No	ClinGen TOPMed gnomAD
CA276495316 rs1012031593	275	I>F		No	ClinGen TOPMed gnomAD
CA394057446 rs1012031593	275	I>V		No	ClinGen TOPMed gnomAD
CA7773200 rs758749924	277	N>D		No	ClinGen ExAC gnomAD
rs1280315747 CA394057461	277	N>S		No	ClinGen TOPMed
rs778288105 CA7773201	278	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA394057473 rs1368299088	279	L>P		No	ClinGen gnomAD
rs1446317644 CA394057482	281	L>V		No	ClinGen TOPMed gnomAD
CA7773202 rs746601840	283	V>I		No	ClinGen ExAC TOPMed gnomAD
CA394057494 rs746601840	283	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7773203 rs757027267	284	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1339170178 CA394057502	284	N>T		No	ClinGen TOPMed
CA394057521 rs1172340488	285	Q>H		No	ClinGen TOPMed gnomAD
rs2685127 CA7773204 VAR_048090	286	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA394057532 rs2685127	286	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773208 rs1555470816	288	A>T		No	ClinGen Ensembl
rs749211265 CA7773210	288	A>V		No	ClinGen ExAC gnomAD
rs201324374 CA7773212	289	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768369627 CA7773211	289	A>T		No	ClinGen ExAC gnomAD
rs201324374 CA7773213	289	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs759614191 CA7773216	290	H>R		No	ClinGen ExAC gnomAD
rs956040111 CA276495340 COSM1163113	290	H>Y	pancreas [Cosmic]	No	ClinGen cosmic curated Ensembl
rs201912828 CA394057582	291	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394057586 rs368987592	291	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773219 rs368987592	291	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773218 rs201912828	291	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs147940951 COSM110467 CA276495384	292	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs147940951 CA7773220	292	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA7773221 rs752037022	292	E>V		No	ClinGen ExAC gnomAD
rs200893733 CA7773222	293	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA394057613 rs1447634085	294	L>I		No	ClinGen gnomAD
rs200200585 CA7773224	295	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1188011565 CA394057624	295	A>T		No	ClinGen gnomAD
rs200200585 CA7773223	295	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA276495435 rs933047026	296	G>A		No	ClinGen TOPMed
rs933047026 CA276495433	296	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7773227 rs749239561	296	G>S		No	ClinGen ExAC gnomAD
rs768650506 CA7773228	300	A>T		No	ClinGen ExAC gnomAD
CA394057700 rs778650775	301	A>G		No	ClinGen ExAC TOPMed gnomAD
CA7773229 rs778650775	301	A>V		No	ClinGen ExAC TOPMed gnomAD
rs200005538 CA7773230 COSM39275	303	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM1377045 rs771878372 CA7773231	303	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs776873601 CA7773232	304	F>L		No	ClinGen ExAC TOPMed gnomAD
CA276495475 rs556947013	305	R>G		No	ClinGen 1000Genomes ExAC TOPMed
rs371259231 CA7773236	305	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371259231 CA7773235	305	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773233 rs556947013	305	R>W		No	ClinGen 1000Genomes ExAC TOPMed
rs763549092 CA394057751	306	G>A		No	ClinGen ExAC TOPMed gnomAD
rs763549092 CA7773237	306	G>E		No	ClinGen ExAC TOPMed gnomAD
CA276495487 rs961972698	306	G>W		No	ClinGen TOPMed
CA7773240 rs762217040	307	Q>R		No	ClinGen ExAC gnomAD
CA394057822 rs1409374785	308	V>L		No	ClinGen gnomAD
rs201756210 CA7773269	309	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs746819708 CA276495625	310	F>L		No	ClinGen ExAC gnomAD
CA7773273 rs367697402	311	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773274 rs201173019	312	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA394057889 rs1290745812	313	V>A		No	ClinGen gnomAD
rs1230092987 CA394057881	313	V>M		No	ClinGen TOPMed gnomAD
CA394057893 rs1222322395	314	D>N		No	ClinGen TOPMed
CA7773277 rs768786654	315	V>L		No	ClinGen ExAC TOPMed gnomAD
rs768786654 CA7773276	315	V>M		No	ClinGen ExAC TOPMed gnomAD
rs45459806 CA394057922	316	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773278 rs145351921	316	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276495634 rs145351921	316	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs45459806 CA7773279	316	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1185975678 CA394057929	317	A>T		No	ClinGen gnomAD
rs1386176626 CA394057935 COSM1581439	317	A>V	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA7773282 rs548225140	318	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	319	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1410776705 CA394057949	319	N>S		No	ClinGen gnomAD
rs1333536958 CA394057963	321	H>D		No	ClinGen TOPMed gnomAD
rs1333536958 CA394057962	321	H>Y		No	ClinGen TOPMed gnomAD
rs752271699 CA7773286	322	V>A		No	ClinGen ExAC gnomAD
CA7773284 rs199881504	322	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs199881504 CA7773285	322	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA394057973 rs763986879	323	L>M		No	ClinGen ExAC gnomAD
rs1249444700 CA394057977	323	L>R		No	ClinGen gnomAD
rs1359895366 CA620305018	324	Q>*		No	ClinGen gnomAD
CA7773289 rs751537258	324	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA7773290 rs756960309	324	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs781137424 CA7773291	326	F>L		No	ClinGen ExAC gnomAD
rs947940575 CA276495697	326	F>L		No	ClinGen Ensembl
rs779128222 CA7773294	327	G>A		No	ClinGen ExAC TOPMed gnomAD
rs749460401 CA7773292 CA7773293	327	G>R		No	ClinGen ExAC gnomAD
rs748292003 CA7773295	328	L>F		No	ClinGen ExAC TOPMed gnomAD
rs772218677 CA7773296	328	L>H		No	ClinGen ExAC gnomAD
rs773555888 CA7773297	329	K>N		No	ClinGen ExAC gnomAD
CA276495723 rs906326619	330	A>T		No	ClinGen gnomAD
CA7773298 rs747556946	330	A>V		No	ClinGen ExAC TOPMed gnomAD
rs200996059 CA7773299	331	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs777039250 CA7773300	332	A>V		No	ClinGen ExAC gnomAD
rs369218895 CA7773301	333	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs763690369 CA7773306	334	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762318701 CA7773305	334	P>S		No	ClinGen ExAC
CA7773308 rs761821338	335	T>A		No	ClinGen ExAC
CA394058041 rs1434318867	335	T>I		No	ClinGen gnomAD
CA394058037 rs761821338	335	T>P		No	ClinGen ExAC
rs1596943967 CA394058044	336	L>R		No	ClinGen Ensembl
CA7773309 rs376635129	337	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773310 rs750307363	337	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7773312 rs369804507	339	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs925341504 CA276495847	340	N>I		No	ClinGen TOPMed gnomAD
rs925341504 CA394058065	340	N>S		No	ClinGen TOPMed gnomAD
rs925341504 CA394058066	340	N>T		No	ClinGen TOPMed gnomAD
CA7773313 rs752996989	340	N>Y		No	ClinGen ExAC gnomAD
rs758345743 CA7773314	341	L>I		No	ClinGen ExAC TOPMed gnomAD
CA394058072 rs1203915428	341	L>R		No	ClinGen gnomAD
rs1447937047 CA394058091	344	T>I		No	ClinGen gnomAD
rs199850017 CA7773315	344	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs45612235 CA7773317	345	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394058105 rs1411354096	346	K>N		No	ClinGen gnomAD
CA7773318 rs781506454	346	K>R		No	ClinGen ExAC TOPMed gnomAD
rs746279682 CA394058114	347	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA394058116 rs1287050015	348	A>P		No	ClinGen gnomAD
CA394058115 rs1287050015	348	A>T		No	ClinGen gnomAD
CA7773320 rs770165640	348	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs762669316 CA7773322	350	V>A		No	ClinGen ExAC gnomAD
CA394058135 rs1343215550	351	D>G		No	ClinGen gnomAD
rs45503792 CA7773325	352	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs45503792 CA7773324	352	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746140719	353	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs767599249 CA7773327	353	G>S		No	ClinGen ExAC gnomAD
rs760509474 CA394058150	354	P>H		No	ClinGen ExAC TOPMed gnomAD
CA7773329 rs760509474	354	P>L		No	ClinGen ExAC TOPMed gnomAD
rs768062505 CA276495932	354	P>S		No	ClinGen TOPMed gnomAD
CA276495933 rs987648566	356	T>A		No	ClinGen Ensembl
CA394058162 rs1209583037	356	T>I		No	ClinGen gnomAD
CA7773334 rs200219634	357	A>P		No	ClinGen ExAC TOPMed gnomAD
rs200219634 CA394058163	357	A>S		No	ClinGen ExAC TOPMed gnomAD
rs200219634 CA7773333	357	A>T		No	ClinGen ExAC TOPMed gnomAD
rs375852621 CA7773335	357	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781628123 CA7773336	358	A>E		No	ClinGen ExAC TOPMed gnomAD
rs781628123 CA276495967	358	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1461954224 CA394058171	359	S>P		No	ClinGen TOPMed
rs770075649 CA7773338	361	T>N		No	ClinGen ExAC gnomAD
CA394058191 rs770075649	361	T>S		No	ClinGen ExAC gnomAD
CA394058193 rs1162384959	362	A>T		No	ClinGen gnomAD
CA394058198 rs1363505419	362	A>V		No	ClinGen gnomAD
CA394058246 rs535742977	365	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773699101 CA7773342	366	A>V		No	ClinGen ExAC TOPMed
rs201555942 CA7773344	367	V>I		No	ClinGen ExAC gnomAD
CA7773346 rs760706106	368	L>P		No	ClinGen ExAC gnomAD
CA7773345 rs199529442	368	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs776557737 CA7773348	369	N>D		No	ClinGen ExAC gnomAD
rs764426526 CA7773350	370	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7773352 rs757287656	370	G>D		No	ClinGen ExAC gnomAD
rs764426526 CA7773351	370	G>S		No	ClinGen ExAC TOPMed gnomAD
rs767586577 CA7773353	371	Q>*		No	ClinGen ExAC gnomAD
CA7773354 rs750870200	371	Q>P		No	ClinGen ExAC gnomAD
CA7773355 rs756668913	372	V>I		No	ClinGen ExAC TOPMed gnomAD
CA394058325 rs1182920068	373	K>E		No	ClinGen gnomAD
CA7773399 rs751287098	375	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA7773398 rs777520679	375	Y>H		No	ClinGen ExAC gnomAD
rs1344011448 CA394059280	376	L>F		No	ClinGen TOPMed gnomAD
rs1344011448 CA394059276 COSM970417	376	L>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA7773401 rs780580369	378	S>G		No	ClinGen ExAC gnomAD
CA394059311 rs1308480781	378	S>N		No	ClinGen TOPMed
rs1308480781 CA394059314	378	S>T		No	ClinGen TOPMed
rs199813441 CA7773402	379	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199813441 CA276496632	379	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199813441 CA276496630	379	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773403 rs769683958	380	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7773404 rs45529833 VAR_048091	382	P>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs45529833 CA394059384	382	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1184799496 CA394059406	383	P>A		No	ClinGen TOPMed
rs1472796664	383	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA276496677 rs949137926	387	Q>*		No	ClinGen TOPMed gnomAD
CA394059506 rs540057615	388	R>G		No	ClinGen ExAC TOPMed gnomAD
rs400037 CA7773409 VAR_048092	388	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA276496679 rs540057615	388	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7773411 rs771034938	389	P>S		No	ClinGen ExAC TOPMed gnomAD
CA394059531 rs1201344404	390	V>G		No	ClinGen TOPMed gnomAD
CA276496693 rs967990870	390	V>L		No	ClinGen Ensembl
rs760057508 CA7773414	392	T>N		No	ClinGen ExAC
CA276496714 rs778970931	393	L>F		No	ClinGen TOPMed gnomAD
CA394059557 rs778970931	393	L>I		No	ClinGen TOPMed gnomAD
CA394059570 rs1489629692	394	V>E		No	ClinGen TOPMed
CA276496717 rs200448607	394	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773417 rs200448607	394	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs376852015 CA7773418	395	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs376852015 CA394059579	395	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1422901769 CA394059573	395	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs376852015 CA394059578	395	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA394059600 rs1268728241	397	N>I		No	ClinGen TOPMed
CA394059623 rs1428286969	399	E>K		No	ClinGen gnomAD
CA394059640 rs1326976693	400	Q>*		No	ClinGen TOPMed
rs1596949074 CA394059658	401	V>G		No	ClinGen Ensembl
CA7773420 rs375517847	401	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141027540 CA7773422	402	A>V		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs373601500 CA7773425	404	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201901210 CA7773427	405	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201901210 CA7773426	405	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1321950121 CA394059724	406	T>I		No	ClinGen TOPMed
TCGA novel	407	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778740518 CA7773432	410	F>C		No	ClinGen ExAC TOPMed
CA7773433 rs778740518	410	F>S		No	ClinGen ExAC TOPMed
rs1567251674 CA394059790	411	V>D		No	ClinGen Ensembl
CA394059815 rs1567251679	413	F>L		No	ClinGen Ensembl
rs540602732 CA7773462	416	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs562178952 CA7773464	416	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7773463 rs562178952	416	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7773467 rs544466936	417	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544466936 CA7773468	417	W>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394059900 rs1312771320	417	W>L		No	ClinGen TOPMed
rs1325311999 CA394059894	417	W>R		No	ClinGen TOPMed
rs1312771320 CA394059898	417	W>S		No	ClinGen TOPMed
rs765872416 CA394059907	418	C>G		No	ClinGen ExAC gnomAD
rs765872416 CA7773470	418	C>R		No	ClinGen ExAC gnomAD
rs765872416 CA7773469	418	C>S		No	ClinGen ExAC gnomAD
CA394059910 rs1446775968	418	C>Y		No	ClinGen gnomAD
rs1302638034 CA394059927	419	T>I		No	ClinGen TOPMed
rs752712929 CA7773473	420	H>P		No	ClinGen ExAC gnomAD
rs765036253 CA7773472	420	H>Y		No	ClinGen ExAC gnomAD
rs1279264197 CA394059989	424	M>T		No	ClinGen Ensembl
CA394060005 rs1596949694	425	A>G		No	ClinGen Ensembl
rs758063486 CA7773474	425	A>T		No	ClinGen ExAC gnomAD
rs777636609 CA7773475	426	P>S		No	ClinGen ExAC gnomAD
CA394060024 rs1178492539	427	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7773476 rs746061835	428	W>*		No	ClinGen ExAC gnomAD
CA394060043 rs1381417947	429	E>K		No	ClinGen gnomAD
rs756471109 CA7773477	430	A>E		No	ClinGen ExAC gnomAD
CA394060099 rs1567251817	433	E>D		No	ClinGen Ensembl
rs1320799677 CA394060095	433	E>G		No	ClinGen gnomAD
rs768874811 CA394060091 COSM163388	433	E>K	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7773480 rs768874811	433	E>Q		No	ClinGen ExAC gnomAD
rs1596949770 TCGA novel CA394060117	435	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs1224882810 CA394060130	436	Q>*		No	ClinGen gnomAD
rs1567251821 CA394060142	436	Q>H		No	ClinGen Ensembl
CA7773482 rs779246274	438	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA7773485 rs369453251	439	E>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773484 rs772314078	439	E>K		No	ClinGen ExAC TOPMed gnomAD
rs954018375 CA276497016	440	D>H		No	ClinGen TOPMed
CA276497027 rs986191612	442	I>L		No	ClinGen Ensembl
rs1168383612 CA394060214	442	I>T		No	ClinGen TOPMed gnomAD
CA394060221 rs1017094458	443	I>F		No	ClinGen TOPMed gnomAD
CA276497043 rs1017094458	443	I>V		No	ClinGen TOPMed gnomAD
rs770623196 CA7773488	444	A>G		No	ClinGen ExAC TOPMed gnomAD
CA7773487 rs760293954	444	A>P		No	ClinGen ExAC TOPMed gnomAD
CA276497057 rs760293954	444	A>S		No	ClinGen ExAC TOPMed gnomAD
rs776288299 CA394060241	445	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7773490 rs776288299	445	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA7773493 rs372514598	447	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1419856553 CA394060273	448	A>T		No	ClinGen gnomAD
rs763004639 CA7773494	449	T>A		No	ClinGen ExAC gnomAD
CA7773496 COSM3817937 rs763790305	449	T>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA394060299 rs1343310017	450	A>T		No	ClinGen gnomAD
CA394060324 rs371087103	452	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773502 COSM1493696 rs371087103	452	E>K	kidney Variant assessed as Somatic; 4.643e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA7773501 rs371087103	452	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276497120 rs905325415	453	L>M		No	ClinGen TOPMed gnomAD
CA394060335 rs905325415	453	L>V		No	ClinGen TOPMed gnomAD
rs754944090 CA7773503	454	D>G		No	ClinGen ExAC gnomAD
CA7773504 rs779060528	455	A>V		No	ClinGen ExAC TOPMed gnomAD
rs748600407 CA7773505	456	F>C		No	ClinGen ExAC gnomAD
CA394060378 rs777980410	457	A>P		No	ClinGen ExAC TOPMed gnomAD
rs777980410 CA7773507	457	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7773508 rs747329727	458	V>A		No	ClinGen ExAC gnomAD
rs1440054220 CA394060407	459	H>R		No	ClinGen TOPMed gnomAD
rs1567251891	459	H>STMGSKEEL*		No	Ensembl
rs113159258 CA7773510 COSM1377081	460	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1426187039 CA394060450	462	P>S		No	ClinGen TOPMed gnomAD
CA394060469 rs1393888312	463	T>A		No	ClinGen TOPMed
CA276497207 rs763405255	465	K>Q		No	ClinGen gnomAD
CA394060531 rs1378352443	466	Y>*		No	ClinGen gnomAD
rs775132153 CA7773515	466	Y>S		No	ClinGen ExAC gnomAD
rs1245658758 CA394060542	467	F>V		No	ClinGen TOPMed gnomAD
rs185235292 CA7773516	468	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276497218 rs889813866	468	P>T		No	ClinGen TOPMed
rs1250765063 CA394060572	469	A>S		No	ClinGen TOPMed gnomAD
CA7773518 rs751560976	470	G>R		No	ClinGen ExAC gnomAD
rs367811188 CA7773520	471	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs367811188 CA276497232	471	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs754052786 CA7773521	472	G>D		No	ClinGen ExAC gnomAD
CA394060610 rs1383171204	472	G>R		No	ClinGen gnomAD
CA7773524 rs118177911	473	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs116969376 CA276497279	473	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773525 rs116969376	473	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs118177911 CA7773523	473	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1258102758 CA394060634	474	K>*		No	ClinGen TOPMed
CA276497483 rs897258052	476	I>T		No	ClinGen TOPMed gnomAD
rs201317550 CA7773569	478	Y>*		No	ClinGen ESP TOPMed
rs374859186 CA7773567	478	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415571644 CA394060833	479	K>E		No	ClinGen gnomAD
rs930107119 CA276497493	479	K>I		No	ClinGen TOPMed gnomAD
TCGA novel	479	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394060888 rs138762531	481	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762285161 CA7773571	481	T>P		No	ClinGen ExAC TOPMed gnomAD
rs138762531 CA7773572	481	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1299021254 CA394060905	482	R>K		No	ClinGen TOPMed gnomAD
CA7773575 rs45585539	483	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773574 rs45585539	483	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773573 rs750924414	483	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA394060932 rs1276718054	484	L>M		No	ClinGen gnomAD
CA7773576 rs753512209	484	L>P		No	ClinGen ExAC gnomAD
CA7773577 rs752703443	485	E>G		No	ClinGen ExAC TOPMed gnomAD
CA394060954 rs1252947705	485	E>K		No	ClinGen TOPMed
rs752703443 CA276497515	485	E>V		No	ClinGen ExAC TOPMed gnomAD
CA394060984 rs1314905461	486	T>A		No	ClinGen gnomAD
rs201830948 CA7773580	487	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA276497542 rs374072214	488	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773581 rs374072214	488	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs746934284 CA7773582	489	K>M		No	ClinGen ExAC TOPMed gnomAD
rs746934284 CA7773583	489	K>T		No	ClinGen ExAC TOPMed gnomAD
CA276497555 rs1022432757	492	D>H		No	ClinGen TOPMed
rs768913981 CA394061099	493	N>D		No	ClinGen ExAC TOPMed
rs768913981 CA7773587	493	N>H		No	ClinGen ExAC TOPMed
CA276497562 rs866724530	494	G>E		No	ClinGen Ensembl
rs200635785 CA7773590	494	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394061119 rs200635785	494	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1441909022 CA394061132	495	G>C		No	ClinGen TOPMed gnomAD
CA394061134 rs1405391445	495	G>D		No	ClinGen TOPMed
rs1441909022 CA394061129	495	G>R		No	ClinGen TOPMed gnomAD
rs1405391445 CA394061138	495	G>V		No	ClinGen TOPMed
rs199589252 CA7773593 COSM1220063	496	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs766759491 CA7773597	498	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1422998220 CA394061173	498	P>S		No	ClinGen gnomAD
rs370277985 CA394061182	499	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA276497606 rs373732401	499	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773601 rs373732401	499	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773599 rs370277985	499	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs370277985 CA7773600	499	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1370747260 CA394061192	500	E>K		No	ClinGen TOPMed
rs752407010 CA7773603	501	E>*		No	ClinGen ExAC gnomAD
rs757923964 CA7773604	501	E>A		No	ClinGen ExAC gnomAD
rs752407010 CA394061208	501	E>K		No	ClinGen ExAC gnomAD
CA7773605 VAR_048093 rs1048786	502	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA394061223 rs1048786	502	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7773606 rs746052617	503	P>L		No	ClinGen ExAC TOPMed gnomAD
CA276497639 rs746052617	503	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1436709144 CA394061235	503	P>T		No	ClinGen TOPMed
CA394061272 rs1055946099	505	E>A		No	ClinGen TOPMed gnomAD
rs745610054 CA394061274	505	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1055946099 CA276497682	505	E>G		No	ClinGen TOPMed gnomAD
CA7773608 rs531336265	505	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA7773610 rs375497846	506	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7773611 rs774485883	508	A>V		No	ClinGen ExAC gnomAD
rs762035501 CA7773612	509	P>L		No	ClinGen ExAC TOPMed gnomAD
CA394061318 rs1179594893	509	P>S		No	ClinGen gnomAD
CA394061314 rs1179594893	509	P>T		No	ClinGen gnomAD
CA394061340 rs1193086412	510	F>L		No	ClinGen TOPMed
CA7773614 rs201429930	511	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394061344 rs1165214211	511	P>T		No	ClinGen gnomAD
rs199996785 CA7773644	512	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA394062005 rs756651561	512	E>D		No	ClinGen ExAC gnomAD
CA394062009 rs1478177137	513	P>A		No	ClinGen gnomAD
CA276499368 rs1055874189	513	P>L		No	ClinGen TOPMed gnomAD
rs201336797 CA7773646	514	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201336797 CA394062027	514	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201336797 CA394062029	514	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs888298216 CA276499411	515	A>G		No	ClinGen Ensembl
rs373626079 CA276499401	515	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs373626079 COSM471693 CA7773649	515	A>T	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1399961715 CA394062060	516	N>S		No	ClinGen gnomAD
rs754835754 CA7773651	518	T>I		No	ClinGen ExAC gnomAD
rs777791865 CA7773652	519	M>L		No	ClinGen ExAC TOPMed gnomAD
CA394062097 rs777791865	519	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7773653 rs747269171	520	G>R		No	ClinGen ExAC gnomAD
CA276499466 rs999600496	522	K>E		No	ClinGen TOPMed
CA7773658 rs770475643	523	E>*		No	ClinGen ExAC gnomAD
CA7773657 rs770475643	523	E>K		No	ClinGen ExAC gnomAD
rs1488760378 CA394062186	524	E>K		No	ClinGen gnomAD
CA394062202 rs763185526	525	L>M		No	ClinGen ExAC gnomAD
CA7773663 rs773813488	526	L>L		No	ClinGen ExAC TOPMed gnomAD
CA7773664 rs761584267	526	L>Y		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q13087

4 regional properties for Q13087

Type	Name	Position	InterPro Accession
domain	Thioredoxin domain	27 - 152	IPR013766-1
domain	Thioredoxin domain	367 - 496	IPR013766-2
conserved_site	Thioredoxin, conserved site	63 - 81	IPR017937-1
conserved_site	Thioredoxin, conserved site	410 - 428	IPR017937-2

Functions

		Description
EC Number	5.3.4.1	Transposing S-S bonds
Subcellular Localization	Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.

4 GO annotations of molecular function

Name	Definition
disulfide oxidoreductase activity	Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
protein disulfide isomerase activity	Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
protein-disulfide reductase activity	Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
steroid binding	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

4 GO annotations of biological process

Name	Definition
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein folding in endoplasmic reticulum	A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
protein retention in ER lumen	The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q29RV1	PDIA4	Protein disulfide-isomerase A4	Bos taurus (Bovine)	PR
Q8N807	PDILT	Protein disulfide-isomerase-like protein of the testis	Homo sapiens (Human)	PR
Q5WA72	PDIL1-5	Protein disulfide isomerase-like 1-5	Oryza sativa subsp japonica (Rice)	PR
Q17770	pdi-2	Protein disulfide-isomerase 2	Caenorhabditis elegans	PR
Q66GQ3	PDIL1-6	Protein disulfide isomerase-like 1-6	Arabidopsis thaliana (Mouse-ear cress)	PR
A3KPF5	PDIL1-5	Protein disulfide isomerase-like 1-5	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSRQLLPVLL	LLLLRASCPW	GQEQGARSPS	EEPPEEEIPK	EDGILVLSRH	TLGLALREHP
70	80	90	100	110	120
ALLVEFYAPW	CGHCQALAPE	YSKAAAVLAA	ESMVVTLAKV	DGPAQRELAE	EFGVTEYPTL
130	140	150	160	170	180
KFFRNGNRTH	PEEYTGPRDA	EGIAEWLRRR	VGPSAMRLED	EAAAQALIGG	RDLVVIGFFQ
190	200	210	220	230	240
DLQDEDVATF	LALAQDALDM	TFGLTDRPRL	FQQFGLTKDT	VVLFKKFDEG	RADFPVDEEL
250	260	270	280	290	300
GLDLGDLSRF	LVTHSMRLVT	EFNSQTSAKI	FAARILNHLL	LFVNQTLAAH	RELLAGFGEA
310	320	330	340	350	360
APRFRGQVLF	VVVDVAADNE	HVLQYFGLKA	EAAPTLRLVN	LETTKKYAPV	DGGPVTAASI
370	380	390	400	410	420
TAFCHAVLNG	QVKPYLLSQE	IPPDWDQRPV	KTLVGKNFEQ	VAFDETKNVF	VKFYAPWCTH
430	440	450	460	470	480
CKEMAPAWEA	LAEKYQDHED	IIIAELDATA	NELDAFAVHG	FPTLKYFPAG	PGRKVIEYKS
490	500	510	520
TRDLETFSKF	LDNGGVLPTE	EPPEEPAAPF	PEPPANSTMG	SKEEL