Q62845
PR
Gene name |
Cntn4 |
Protein name |
Contactin-4 |
Names |
Brain-derived immunoglobulin superfamily protein 2, BIG-2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:116658 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62845
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62845-F1 | Predicted | AlphaFoldDB |
No variants for Q62845
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62845 | |||||
No associated diseases with Q62845
25 regional properties for Q62845
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype 2 | 41 - 107 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 238 - 302 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 328 - 391 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 420 - 484 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 510 - 583 | IPR003598-5 |
| domain | Immunoglobulin subtype | 32 - 119 | IPR003599-1 |
| domain | Immunoglobulin subtype | 129 - 215 | IPR003599-2 |
| domain | Immunoglobulin subtype | 232 - 315 | IPR003599-3 |
| domain | Immunoglobulin subtype | 322 - 402 | IPR003599-4 |
| domain | Immunoglobulin subtype | 414 - 495 | IPR003599-5 |
| domain | Immunoglobulin subtype | 504 - 594 | IPR003599-6 |
| domain | Fibronectin type III | 597 - 697 | IPR003961-1 |
| domain | Fibronectin type III | 700 - 799 | IPR003961-2 |
| domain | Fibronectin type III | 801 - 899 | IPR003961-3 |
| domain | Fibronectin type III | 900 - 995 | IPR003961-4 |
| domain | Immunoglobulin-like domain | 32 - 117 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 122 - 206 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 225 - 311 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 316 - 400 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 406 - 493 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 497 - 586 | IPR007110-6 |
| domain | Immunoglobulin I-set | 26 - 115 | IPR013098-1 |
| domain | Immunoglobulin I-set | 318 - 401 | IPR013098-2 |
| domain | Immunoglobulin I-set | 409 - 493 | IPR013098-3 |
| domain | Contactin-4, Ig6 | 496 - 597 | IPR033007 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of membrane | The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell-cell adhesion mediator activity | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| dendrite self-avoidance | The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| negative regulation of neuron differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32004 | L1CAM | Neural cell adhesion molecule L1 | Homo sapiens (Human) | PR |
| Q810U3 | Nfasc | Neurofascin | Mus musculus (Mouse) | PR |
| P11627 | L1cam | Neural cell adhesion molecule L1 | Mus musculus (Mouse) | PR |
| Q05695 | L1cam | Neural cell adhesion molecule L1 | Rattus norvegicus (Rat) | PR |
| Q62682 | Cntn3 | Contactin-3 | Rattus norvegicus (Rat) | PR |
| Q9Z2J4 | Nexn | Nexilin | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLPWELLVL | QSFMLCLADD | YTLHGPVFVQ | EPSHVMFPLD | SEEKKVKLSC | EVKGNPKPHI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RWKLNGTDVD | IGMDFRYSVV | EGSLLINNPN | KTQDSGTYQC | IATNSFGTIV | SREAKLQFAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LENFKTRTRS | TVSVRRGQGM | VLLCGPPPHS | GELSYAWIFN | EHPSYQDNRR | FVSQETGNLY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IAKVEKADVG | NYTCVVTNTV | TSHQVLGPPT | PLILRNDGVM | GEYEPKIEVQ | FPETVPAEKG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STVKLECFAL | GNPVPTILWR | RADGKPIARK | ARRHKSSGIL | EIPNFQQEDA | GSYECVAENS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RGKNIAKGQV | TFYAQPNWVQ | IINDIHVAME | ESVFWECKAN | GRPKPTYRWL | KNGDPLLTRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RIQIEQGTLN | ITIVNLSDAG | MYQCVAENKH | GVIYASAELS | VIAESPDFSR | TLLKRVTLVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGGEVVIECK | PKASPRPVYT | WRKGREILRE | NERITISEDG | NLRIINVTKS | DAGSYTCIAT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NHFGTASSTG | NVVVKDPTKV | MVPPSSMDVT | VGESIVLPCQ | VTHDHSLDIV | FTWTFNGHLI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DFDKDGDHFE | RVGGQDSAGD | LMIRNIQLKH | AGKYVCMVQT | SVDKLSAAAD | LIVRGPPGPP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAVTIDEITD | TTAQLSWRPG | PDNHSPITMY | VIQARTPFSV | GWQAVSTVPE | LVDGKTFTAT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VVGLNPWVEY | EFRTVAANVI | GIGEPSRPSE | KRRTEEALPE | VTPANVSGGG | GSKSELVITW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ETVPEELQNG | RGFGYVVAFR | PHGKMIWMLT | VLASADASRY | VFRNESVRPF | SPFEVKVGVF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NNKGEGPFSP | TTLVYSAEEE | PTKPPASIFA | RSLSATDIEV | FWASPIGKNR | GRIQGYEVKY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WRHDDKEENA | RKIRTVGNQT | STKITNLKGN | ALYHLSVKAY | NSAGTGPSSA | AVNVTTRKPP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PSQPPGNIIW | NSSDSKIILN | WDQVKALDNE | SEVKGYKVLY | RWNRQSSTSV | IETNKTSVEL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SLPFDEDYII | EIKPFSDGGD | GSSSEQIRIP | KISNSYARGS | GASTSNACTL | SAISTIMISL |
| TARSSL |