Q05695

PR
Gene name
L1cam (Caml1)
Protein name
Neural cell adhesion molecule L1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:50687
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1120-1259 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05695

Entry ID Method Resolution Chain Position Source
AF-Q05695-F1 Predicted AlphaFoldDB

No variants for Q05695

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05695

No associated diseases with Q05695

25 regional properties for Q05695

Type Name Position InterPro Accession
domain Immunoglobulin subtype 2 48 - 120 IPR003598-1
domain Immunoglobulin subtype 2 254 - 318 IPR003598-2
domain Immunoglobulin subtype 2 344 - 410 IPR003598-3
domain Immunoglobulin subtype 2 438 - 503 IPR003598-4
domain Immunoglobulin subtype 2 529 - 597 IPR003598-5
domain Immunoglobulin subtype 42 - 132 IPR003599-1
domain Immunoglobulin subtype 142 - 229 IPR003599-2
domain Immunoglobulin subtype 248 - 329 IPR003599-3
domain Immunoglobulin subtype 338 - 421 IPR003599-4
domain Immunoglobulin subtype 432 - 514 IPR003599-5
domain Immunoglobulin subtype 523 - 608 IPR003599-6
domain Fibronectin type III 611 - 711 IPR003961-1
domain Fibronectin type III 714 - 809 IPR003961-2
domain Fibronectin type III 811 - 916 IPR003961-3
domain Fibronectin type III 917 - 1014 IPR003961-4
domain Immunoglobulin-like domain 35 - 128 IPR007110-1
domain Immunoglobulin-like domain 138 - 225 IPR007110-2
domain Immunoglobulin-like domain 239 - 327 IPR007110-3
domain Immunoglobulin-like domain 332 - 419 IPR007110-4
domain Immunoglobulin-like domain 424 - 506 IPR007110-5
domain Immunoglobulin-like domain 517 - 600 IPR007110-6
domain Immunoglobulin I-set 247 - 328 IPR013098-1
domain Immunoglobulin I-set 432 - 513 IPR013098-2
domain Immunoglobulin I-set 518 - 607 IPR013098-3
domain Neurofascin/L1/NrCAM, C-terminal domain 1146 - 1235 IPR026966

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, growth cone
  • Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones of hippocampal neurons (PubMed:18519736)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axonal growth cone The migrating motile tip of a growing nerve cell axon.
cell surface The external part of the cell wall and/or plasma membrane.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic growth cone The migrating motile tip of a growing nerve cell dendrite.
endosome A vacuole to which materials ingested by endocytosis are delivered.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
terminal bouton Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

7 GO annotations of molecular function

Name Definition
axon guidance receptor activity Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
identical protein binding Binding to an identical protein or proteins.
integrin binding Binding to an integrin.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
protein domain specific binding Binding to a specific domain of a protein.
protein self-association Binding to a domain within the same polypeptide.
sialic acid binding Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.

29 GO annotations of biological process

Name Definition
axon development The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle.
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
cell-cell adhesion mediated by integrin The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules.
cellular response to dexamethasone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
cellular response to thyroxine stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
cellular response to transforming growth factor beta stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
dopaminergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
homotypic cell-cell adhesion The attachment of a cell to a second cell of the identical type via adhesion molecules.
leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of axon extension Any process that activates or increases the frequency, rate or extent of axon extension.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell.
positive regulation of cell-substrate adhesion Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
regulation of ERK1 and ERK2 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to thyroid hormone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32004 L1CAM Neural cell adhesion molecule L1 Homo sapiens (Human) PR
Q810U3 Nfasc Neurofascin Mus musculus (Mouse) PR
P11627 L1cam Neural cell adhesion molecule L1 Mus musculus (Mouse) PR
Q62845 Cntn4 Contactin-4 Rattus norvegicus (Rat) PR
Q62682 Cntn3 Contactin-3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT DDISLKCEAR
70 80 90 100 110 120
GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN NSFAQRFQGI YRCYASNNLG
130 140 150 160 170 180
TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ
190 200 210 220 230 240
DERVSMGQNG DLYFANVLTS DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR
250 260 270 280 290 300
LLFPTNSSSH LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN
310 320 330 340 350 360
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR LDCQVQGRPQ
370 380 390 400 410 420
PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV TQCEARNQHG LLLANAYIYV
430 440 450 460 470 480
VQLPARILTK DNQTYMAVEG STAYLLCKAF GAPVPSVQWL DEEGTTVLQD ERFFPYANGH
490 500 510 520 530 540
LGIRDLQAND TGRYFCQAAN DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA
550 560 570 580 590 600
SFDPSLQASI TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE
610 620 630 640 650 660
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE FEDKEMAPEK
670 680 690 700 710 720
WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS PVSETVVTPE AAPEKNPVDV
730 740 750 760 770 780
RGEGNETNNM VITWKPLRWM DWNAPQIQYR VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF
790 800 810 820 830 840
VPYEIKVQAV NNQGKGPEPQ VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV
850 860 870 880 890 900
KGHLRGYNVT YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR
910 920 930 940 950 960
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY LLSYHPLDGE
970 980 990 1000 1010 1020
SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP GEAIVREGGT MALFGKPDFG
1030 1040 1050 1060 1070 1080
NISVTAGENY SVVSWVPREG QCNFRFHILF KALPEGKVSP DHQPQPQYVS YNQSSYTQWD
1090 1100 1110 1120 1130 1140
LQPDTKYEIH LMREKVLLHH LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL
1150 1160 1170 1180 1190 1200
ILCFIKRSKG GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD
1210 1220 1230 1240 1250
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS PINPAVALE