Q9Z2J4
Gene name |
Nexn |
Protein name |
Nexilin |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:246172 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2J4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2J4-F1 | Predicted | AlphaFoldDB |
2 variants for Q9Z2J4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3319749940 | 218 | K>E | No | EVA | |
| rs8164699 | 343 | A>G | No | EVA |
No associated diseases with Q9Z2J4
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cell-substrate junction | A cell junction that forms a connection between a cell and the extracellular matrix. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| cell-cell adhesion mediator activity | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. |
| structural constituent of muscle | The action of a molecule that contributes to the structural integrity of a muscle fiber. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| dendrite self-avoidance | The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNDVSQKAEI | LLSSSKPVPK | SYVPKLGKGD | VKDKFEAMQR | AREERNQRRS | RDEKQRRKEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YIREREWNRR | KQEIKDMLAS | DEEEEPSKVE | KAYVPKLTGT | VKGKFDEMEK | HRQEEQRKRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEERKRRIEQ | DLLEKRKMQR | ELAKRAEQEG | DDSLLITVVP | AKSYRAAANR | KDPEDLDREH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNGRVSQEEE | KTRHEEECRA | LKEAKCLSLV | MDDETEAKKE | SRFPGKLKST | FEELERQRQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRKKQAEEEA | RRRLEEERRA | FEEARRNMVN | EEDESQDTET | VFKEYRPGKL | RLSFEEIERQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RREEEKRKAE | EEARRRMEEE | KKAFAEARRS | MVLDDDSPEI | YKAVSQESLT | PGKLEINFEQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLRQKMEEER | RRTEEERRQK | LEMEKQEFEQ | LRQEMGKEEE | ENESFGLSRE | YEELIKLKRS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSIQAKNLKS | KFEKIGQLSE | KEVQKKIEEE | RAKRRAIDLE | IKEREAENFH | EDDDVDVKPA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKSESPFTHK | VNMKARFEQM | AKARQEEEQR | RIEEQKLLRM | QFEQKEIDAA | LQKKREDDEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEGSIVNGST | TEDEEQTRSG | APWFKKPLRN | TSVVDSEPVR | FTVKVTGEPK | PEVTWWFEGE |
| 610 | 620 | 630 | 640 | 650 | |
| LLQDGEDYQY | IERGETYCLY | LPETFPEDGG | EYMCKAVNSK | GSAASTCILT | IEMDDY |