AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

206-337 (Predicted disordered autoinhibitory region) PR

206-337 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7TPW1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs261505781	24	P>S	No	EVA
rs3388670919	59	E>D	No	EVA
rs1133727111	135	R>S	No	EVA
rs1133394532	138	H>Y	No	EVA
rs1134925295	142	K>R	No	EVA
rs3388673735	171	E>D	No	EVA
rs1131805283	173	H>Q	No	EVA
rs3388670893	195	K>E	No	EVA
rs3388657432	210	R>P	No	EVA
rs3393703441	277	E>*	No	EVA
rs3393839691	277	E>A	No	EVA
rs3388662905	332	L>Q	No	EVA
rs3388670577	378	N>K	No	EVA
rs1132913672	400	E>K	No	EVA
rs3388650851	408	I>T	No	EVA
rs3388673727	459	E>K	No	EVA
rs3388665937	486	R>S	No	EVA
rs3388669974	487	E>*	No	EVA
rs3388670862	488	D>G	No	EVA
rs228830965	489	E>D	No	EVA
rs3388670915	490	E>G	No	EVA
rs3388662883	495	S>N	No	EVA
rs3388665007	535	K>S	No	EVA
rs3388664989	590	N>K	No	EVA
rs3388670646	604	M>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype	519 - 603	IPR003599
domain	Immunoglobulin-like domain	513 - 601	IPR007110
domain	Immunoglobulin I-set	514 - 602	IPR013098

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell junction, adherens junction Cytoplasm, myofibril, sarcomere, Z line	Localizes to the cell-matrix AJ Not found at the cell-cell AJ
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell-substrate junction	A cell junction that forms a connection between a cell and the extracellular matrix.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
cell-cell adhesion mediator activity	The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
structural constituent of muscle	The action of a molecule that contributes to the structural integrity of a muscle fiber.

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
dendrite self-avoidance	The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
homophilic cell adhesion via plasma membrane adhesion molecules	The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.
regulation of cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0ZGT2	NEXN	Nexilin	Homo sapiens (Human)	PR
Q9JIF9	Myot	Myotilin	Mus musculus (Mouse)	PR
Q9Z2J4	Nexn	Nexilin	Rattus norvegicus (Rat)	PR