Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZKK4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZKK4-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZKK4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZKK4 | |||||
No associated diseases with Q5ZKK4
No regional properties for Q5ZKK4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5ZKK4 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| low-density lipoprotein particle receptor binding | Binding to a low-density lipoprotein receptor. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T0U1 | MESD | LRP chaperone MESD | Bos taurus (Bovine) | PR |
| Q14696 | MESD | LRP chaperone MESD | Homo sapiens (Human) | PR |
| Q5U2R7 | Mesd | LRP chaperone MESD | Rattus norvegicus (Rat) | PR |
| A1L243 | mesd | LRP chaperone MESD | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAARWAAL | GLALWLCAAA | HAEEPEGKRR | AGPAKKKDIR | DYNDADMARL | LEQWEKDDDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEGDLPEHKR | PPAPIDFSKI | DPGKPESILK | LTKKGKTLMM | FVTVSGNPTE | KETEEITSLW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGSLFNANYD | VQRFIVGSNR | AIFMLRDGGY | AWEIKDFLIS | QERCADVTLE | GQVYPGKGAD |
| 190 | 200 | 210 | |||
| GSEKGRNKTK | PEKAKKKKDA | EKSKSSHEDN | RAQTKQREDL |