A1L243

PR
Gene name
mesd (mesdc2, zgc:158636)
Protein name
LRP chaperone MESD
Names
LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:791222
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1L243

Entry ID Method Resolution Chain Position Source
AF-A1L243-F1 Predicted AlphaFoldDB

No variants for A1L243

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1L243

No associated diseases with A1L243

No regional properties for A1L243

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A1L243

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
positive regulation of skeletal muscle acetylcholine-gated channel clustering Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0U1 MESD LRP chaperone MESD Bos taurus (Bovine) PR
Q5ZKK4 mesd LRP chaperone MESD Gallus gallus (Chicken) PR
Q14696 MESD LRP chaperone MESD Homo sapiens (Human) PR
Q5U2R7 Mesd LRP chaperone MESD Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASSVGCRTL SVLFLLVLFI TVHCTDTKPK KKKDIRDYND ADMARLLEEW EKDDDIEEGD
70 80 90 100 110 120
LPEHKRSPPP IDFSKIDASK PEELLKMSKK GKTLMVFASV SGNPTEKETE EITGLWQGSL
130 140 150 160 170 180
FNANYDVQRF VVGSNRVIFM LRDGSYAWEI KDFLVSQDRC EDVTVEGQVF PGKNAKKDAK
190 200
GKEQNETKKK GDKKAANRAN KGKQEL