AiPD: Autoinhibited Protein Database

Q14696

Gene name	MESD
Protein name	LRP chaperone MESD
Names	LDLR chaperone MESD, Mesoderm development LRP chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23184
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-130 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-130 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q14696

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q14696-F1	Predicted				AlphaFoldDB

213 variants for Q14696

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs780491808 RCV000853613	203	T>missing	Osteogenesis imperfecta, type 20 [ClinVar]	Yes	ClinVar dbSNP
rs745891632 RCV000853612	211	K>missing	Osteogenesis imperfecta, type 20 [ClinVar]	Yes	ClinVar dbSNP
rs745891632 RCV000853610	212	K>missing	Osteogenesis imperfecta, type 20 [ClinVar]	Yes	ClinVar dbSNP
CA393251488 RCV000853611 rs1021282486	226	R>*	Osteogenesis imperfecta, type 20 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
VAR_083534	226	R>del	OI20 [UniProt]	Yes	UniProt
rs771591040 CA7694056	2	A>S		No	ClinGen ExAC gnomAD
rs771591040 CA7694057	2	A>T		No	ClinGen ExAC gnomAD
rs747563841 CA7694055	2	A>V		No	ClinGen ExAC gnomAD
CA393258598 rs1300723498	3	A>V		No	ClinGen gnomAD
CA7694052 rs61999333	4	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7694051 rs61999333	4	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393258594 rs1366109799	4	S>P		No	ClinGen gnomAD
CA393258573 rs1468421394	5	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA393258566 rs1333829041	5	R>K		No	ClinGen TOPMed
CA393258527 rs1240321364	6	W>G		No	ClinGen gnomAD
CA273381946 rs1013839844	6	W>L		No	ClinGen TOPMed
CA393258530 rs1240321364	6	W>R		No	ClinGen gnomAD
CA7694047 COSM3794455 rs758532744	8	R>C	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs758532744 CA7694048	8	R>G		No	ClinGen ExAC TOPMed gnomAD
CA393258468 rs752656906	8	R>H		No	ClinGen ExAC TOPMed gnomAD
rs752656906 CA7694046	8	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1201683569 CA393258455	9	K>E		No	ClinGen gnomAD
CA393258439 rs1287064698	10	A>S		No	ClinGen TOPMed
CA7694045 rs765791324	10	A>V		No	ClinGen ExAC gnomAD
CA273381914 rs895071087	11	V>L		No	ClinGen TOPMed gnomAD
CA393258415 rs895071087	11	V>M		No	ClinGen TOPMed gnomAD
rs766820623 CA7694042	13	L>R		No	ClinGen ExAC gnomAD
rs773021525 CA7694040	16	A>S		No	ClinGen ExAC gnomAD
CA7694039 rs771584647	16	A>V		No	ClinGen ExAC gnomAD
CA7694037 rs773719701	17	S>F		No	ClinGen ExAC gnomAD
rs779869446 CA7694034	19	L>R		No	ClinGen ExAC TOPMed gnomAD
rs749191367 CA7694035	19	L>V		No	ClinGen ExAC TOPMed gnomAD
rs769595927 CA7694033	23	L>P		No	ClinGen ExAC gnomAD
CA393258080 rs1400245496	26	L>P		No	ClinGen TOPMed gnomAD
CA7694027 rs778056925	27	P>A		No	ClinGen ExAC gnomAD
rs1262519950 CA393258048	28	P>S		No	ClinGen gnomAD
CA7694024 rs146772302	29	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7694025 rs375284217	29	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7694023 rs755585515	31	S>A		No	ClinGen ExAC gnomAD
CA393257988 rs1173030043	31	S>F		No	ClinGen TOPMed
CA393257954 rs1398617919	33	A>T		No	ClinGen TOPMed
CA393257943 rs1260878509	33	A>V		No	ClinGen gnomAD
rs143990493 CA7694021	36	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393257890 rs1042594042	36	G>C		No	ClinGen gnomAD
CA273381817 rs1042594042	36	G>R		No	ClinGen gnomAD
CA7694022 rs143990493	36	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1197724243 CA393257861	37	S>L		No	ClinGen gnomAD
rs750695248 CA7694018	39	G>E		No	ClinGen ExAC gnomAD
CA393257828 rs1428605286	39	G>R		No	ClinGen TOPMed gnomAD
CA393257763 rs1354983173	41	P>L		No	ClinGen TOPMed
rs761365881 CA7694016	41	P>S		No	ClinGen ExAC gnomAD
CA7694014 rs763486733	42	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7694012 rs201646678	43	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393257690 rs1596241080	44	S>A		No	ClinGen Ensembl
rs536255319 CA7694010	45	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745679493 CA7694009	45	T>I		No	ClinGen ExAC TOPMed
rs536255319 CA393257670	45	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7694011 rs536255319	45	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776280664 CA7694007	47	P>L		No	ClinGen ExAC gnomAD
rs768816243 CA7694005	48	P>A		No	ClinGen ExAC TOPMed gnomAD
rs768816243 CA7694006	48	P>S		No	ClinGen ExAC TOPMed gnomAD
CA393257499 rs1460263321	51	K>R		No	ClinGen TOPMed gnomAD
CA273381706 rs932599029	52	K>E		No	ClinGen TOPMed gnomAD
rs1256911593 CA393257337	57	D>N		No	ClinGen gnomAD
COSM1678622 CA7694002 rs755132914	62	D>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1270705890 CA393257111	65	R>H		No	ClinGen gnomAD
rs1270705890 CA393257109	65	R>P		No	ClinGen gnomAD
rs756675505 CA7693999	69	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs866446988 CA273381631	71	E>G		No	ClinGen Ensembl
rs143490497 CA7693998	71	E>K		No	ClinGen ESP ExAC gnomAD
CA7693969 rs370334066	72	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7693968 rs374050071	73	D>G		No	ClinGen ESP ExAC gnomAD
CA393254924 rs374050071	73	D>V		No	ClinGen ESP ExAC gnomAD
rs769066554 CA7693966	76	I>T		No	ClinGen ExAC TOPMed gnomAD
rs763235508 CA7693965	77	E>G		No	ClinGen ExAC gnomAD
rs1408250589 CA393254854	78	E>G		No	ClinGen TOPMed gnomAD
TCGA novel	78	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408250589 CA393254853	78	E>V		No	ClinGen TOPMed gnomAD
rs1247356012 CA393254841	79	G>E		No	ClinGen TOPMed
CA393254817 rs1596237048	80	D>E		No	ClinGen Ensembl
CA7693964 rs775761382	81	L>P		No	ClinGen ExAC gnomAD
CA393254790 rs1270361287	82	P>S		No	ClinGen gnomAD
CA7693963 rs770014867	84	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1240178765 CA393254725	85	K>R		No	ClinGen gnomAD
CA7693962 rs745917376	87	P>H		No	ClinGen ExAC gnomAD
rs1555442592 CA7693960	89	A>V		No	ClinGen Ensembl
CA7693958 rs771409126	90	P>L		No	ClinGen ExAC gnomAD
rs781550236 CA7693959	90	P>S		No	ClinGen ExAC
rs1221874594 CA393254573	92	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1325788593 CA393254536	93	F>L		No	ClinGen gnomAD
rs1283982246 CA393254505	95	K>E		No	ClinGen gnomAD
CA393254495 rs1360484581	95	K>N		No	ClinGen gnomAD
CA7693957 rs370672520	95	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1291059655 CA393254449	97	D>G		No	ClinGen gnomAD
CA393254368 rs1324708747	100	K>Q		No	ClinGen TOPMed
rs1431951848 CA393254360	100	K>R		No	ClinGen gnomAD
CA393254336 rs1349975011	101	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1358881873 CA393254230	104	I>M		No	ClinGen gnomAD
rs778109096 CA7693955	107	M>I		No	ClinGen ExAC gnomAD
CA7693954 rs758089005	108	T>M		No	ClinGen ExAC TOPMed gnomAD
rs148831547 CA393254095	109	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs766243377 CA7693949	111	G>E		No	ClinGen ExAC TOPMed gnomAD
rs145472737 CA7693951 CA7693950	111	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs760649884 CA7693948	112	K>N		No	ClinGen ExAC TOPMed gnomAD
rs750281158 CA7693947	113	T>I		No	ClinGen ExAC TOPMed gnomAD
CA393253989 rs376822687	114	L>F		No	ClinGen ESP TOPMed gnomAD
rs1226768262 CA393253974	114	L>R		No	ClinGen gnomAD
rs376822687 CA273373863	114	L>V		No	ClinGen ESP TOPMed gnomAD
rs1279700209 CA393253951	115	M>I		No	ClinGen Ensembl
CA393253914 rs1305783075	116	M>I		No	ClinGen TOPMed gnomAD
TCGA novel	119	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761650773 CA7693945	119	T>S		No	ClinGen ExAC gnomAD
CA393253837 rs1313338724	120	V>L		No	ClinGen gnomAD
CA393253803 rs1461485763	122	G>R		No	ClinGen gnomAD
rs759545458 CA7693942	124	P>A		No	ClinGen ExAC gnomAD
CA7693943 rs759545458	124	P>T		No	ClinGen ExAC gnomAD
rs776756284 COSM290754 CA7693941	125	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs776756284 CA393253742	125	T>P		No	ClinGen ExAC gnomAD
CA7693940 rs771410960	126	E>A		No	ClinGen ExAC gnomAD
rs1336884171 CA393253722	126	E>K		No	ClinGen gnomAD
rs1596236903 CA393253699	127	K>E		No	ClinGen Ensembl
rs1172475380 CA393253649	129	T>A		No	ClinGen gnomAD
TCGA novel	130	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	130	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393253625 rs1181520926	131	E>K		No	ClinGen TOPMed gnomAD
CA393253601 rs1446737360	132	I>M		No	ClinGen gnomAD
CA7693939 rs778164192	133	T>M		No	ClinGen ExAC TOPMed gnomAD
CA7693938 rs778164192	133	T>R		No	ClinGen ExAC TOPMed gnomAD
CA7693936 rs748473089	135	L>V		No	ClinGen ExAC TOPMed gnomAD
CA273373783 rs1000904744	137	Q>R		No	ClinGen TOPMed
rs369992727 CA7693933	140	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369992727 CA7693934	140	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs534456533 CA7693932	142	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1290120888 CA393253435	144	N>T		No	ClinGen gnomAD
CA7693931 rs368285022	145	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7693929 rs571856723	147	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1008082002 CA273373764	148	Q>*		No	ClinGen TOPMed gnomAD
rs551918262 CA7693928	149	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751463073 CA7693904	151	I>T		No	ClinGen ExAC gnomAD
CA7693903 rs763920725	153	G>E		No	ClinGen ExAC TOPMed gnomAD
CA7693902 rs146044786	155	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7693901 rs754116910	156	R>C		No	ClinGen ExAC TOPMed gnomAD
rs185628590 CA7693900	156	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1203741833 CA393252658	157	A>T		No	ClinGen gnomAD
rs773219081 CA7693898	158	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	159	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7693897 rs768071584	160	M>I		No	ClinGen ExAC gnomAD
rs1203648080 CA393252619	160	M>V		No	ClinGen gnomAD
CA7693896 rs762303952	162	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA273370789 rs1036378913	162	R>H		No	ClinGen TOPMed
rs763187582 CA7693893	163	D>G		No	ClinGen ExAC TOPMed gnomAD
COSM3387086 CA7693894 rs769085988	163	D>N	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA273370769 rs748803320	165	S>R		No	ClinGen TOPMed gnomAD
CA7693892 rs775212077	165	S>T		No	ClinGen ExAC gnomAD
CA273370752 rs1049372369	169	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	170	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779640639 CA273370740	173	F>L		No	ClinGen Ensembl
TCGA novel	174	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1427338905 CA393252422	175	V>F		No	ClinGen gnomAD
CA393252394 rs777525821	176	G>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	176	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7693886 rs777525821	176	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1191586938 CA393252240	181	A>S		No	ClinGen gnomAD
rs1481765687 CA393252190	183	V>L		No	ClinGen TOPMed
rs755846651 CA7693884	184	T>I		No	ClinGen ExAC TOPMed gnomAD
CA273370688 rs780337539	185	L>V		No	ClinGen ExAC TOPMed gnomAD
CA393252141 rs1358762917	186	E>*		No	ClinGen TOPMed gnomAD
rs554192447 CA7693882	187	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1397658721 CA393252110	188	Q>R		No	ClinGen TOPMed
rs1328002658 CA393252048	190	Y>*		No	ClinGen gnomAD
rs767555701 CA7693880 COSM3741691	190	Y>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7693878 rs752136549	192	G>S		No	ClinGen ExAC TOPMed gnomAD
rs763385906 CA7693875	194	G>R		No	ClinGen ExAC TOPMed gnomAD
CA393251952 rs1415115698	194	G>V		No	ClinGen gnomAD
CA7693874 rs775699712	195	G>E		No	ClinGen ExAC gnomAD
CA7693871 rs1555442302	197	S>G		No	ClinGen Ensembl
CA273370587 rs111349315 CA273370574	197	S>R		No	ClinGen Ensembl
CA393251872 rs1476663916	199	E>Q		No	ClinGen gnomAD
rs759229590 CA7693870	200	K>R		No	ClinGen ExAC gnomAD
rs1313781182 CA393251786	202	K>E		No	ClinGen TOPMed
CA273370522 rs565976654	204	K>E		No	ClinGen 1000Genomes
rs1189111257 CA393251677	206	D>E		No	ClinGen gnomAD
rs1240894931 CA393251692	206	D>N		No	ClinGen gnomAD
rs200800639 CA393251666	207	K>N		No	ClinGen 1000Genomes
CA7693866 rs146515688	207	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA393251671 rs1297959457	207	K>R		No	ClinGen gnomAD
CA393251653 rs144118294	208	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1271618365 CA393251664	208	G>S		No	ClinGen gnomAD
rs144118294 CA7693865	208	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs777773938 CA7693863	209	K>Q		No	ClinGen ExAC
CA7693862 rs188746307	210	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs183241539 CA7693861	210	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1273065577 CA393251582	211	K>N		No	ClinGen TOPMed
rs745891632	211	K>R	Variant assessed as Somatic; 9.565e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs745891632	212	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1335302727 CA393251549	216	L>V		No	ClinGen gnomAD
TCGA novel	218	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7693855 COSM3377676 rs750663890	219	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs756370348 CA7693856	219	R>W		No	ClinGen ExAC gnomAD
CA7693854 rs781351101	221	S>F		No	ClinGen ExAC gnomAD
rs751535827 CA7693852	222	K>Q		No	ClinGen ExAC gnomAD
rs763361869 CA273370373	223	E>*		No	ClinGen ExAC TOPMed gnomAD
rs1231850905 CA393251509	223	E>G		No	ClinGen gnomAD
rs763361869 CA7693850	223	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1483718244 CA393251495	225	N>D		No	ClinGen gnomAD
rs1596234849 CA393251492	225	N>S		No	ClinGen Ensembl
CA273370370 rs1021282486	226	R>G		No	ClinGen gnomAD
rs753142107 CA7693849	226	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA393251475 rs1293650238	228	G>A		No	ClinGen gnomAD
CA273370359 rs960104401	230	K>E		No	ClinGen TOPMed gnomAD
CA7693847 rs759933191	231	R>I		No	ClinGen ExAC
rs1190488816 CA393251441	233	D>A		No	ClinGen TOPMed
rs1277912578 CA393251425	235	L>W		No	ClinGen gnomAD

1 associated diseases with Q14696

[MIM: 618644]: Osteogenesis imperfecta 20 (OI20)

An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI20 is a progressive deforming form characterized by osteopenia, skeletal deformity, healed fractures, and newly-acquired fractures. Death due to respiratory failure can occur in some patients. {ECO:0000269|PubMed:31564437}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI20 is a progressive deforming form characterized by osteopenia, skeletal deformity, healed fractures, and newly-acquired fractures. Death due to respiratory failure can occur in some patients. {ECO:0000269|PubMed:31564437}. Note=The disease is caused by variants affecting the gene represented in this entry.

No regional properties for Q14696

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q14696

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum	Released from apoptotic cells and shed photoreceptor outer segments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
low-density lipoprotein particle receptor binding	Binding to a low-density lipoprotein receptor.

7 GO annotations of biological process

Name	Definition
mesoderm development	The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
ossification	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
phagocytosis	A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of skeletal muscle acetylcholine-gated channel clustering	Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein localization to cell surface	A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3T0U1	MESD	LRP chaperone MESD	Bos taurus (Bovine)	PR
Q5ZKK4	mesd	LRP chaperone MESD	Gallus gallus (Chicken)	PR
Q5U2R7	Mesd	LRP chaperone MESD	Rattus norvegicus (Rat)	PR
A1L243	mesd	LRP chaperone MESD	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAASRWARKA	VVLLCASDLL	LLLLLLPPPG	SCAAEGSPGT	PDESTPPPRK	KKKDIRDYND
70	80	90	100	110	120
ADMARLLEQW	EKDDDIEEGD	LPEHKRPSAP	VDFSKIDPSK	PESILKMTKK	GKTLMMFVTV
130	140	150	160	170	180
SGSPTEKETE	EITSLWQGSL	FNANYDVQRF	IVGSDRAIFM	LRDGSYAWEI	KDFLVGQDRC
190	200	210	220	230
ADVTLEGQVY	PGKGGGSKEK	NKTKQDKGKK	KKEGDLKSRS	SKEENRAGNK	REDL